Disclaimer:

Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.

Rocuronium

×

Overview

What is Rocuronium?

Rocuronium Bromide Injection is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration.  Rocuronium bromide is chemically designated as 1-[17β-(acetyloxy)-3-hydroxy-2β-(4-morpholinyl)-5-androstan-16β-yl]-1-(2-propenyl)pyrrolidinium bromide.

The structural formula is:

The partition coefficient of rocuronium bromide in n-octanol/water is 0.5 at 20°C.

Rocuronium bromide injection is supplied as a sterile, nonpyrogenic, isotonic solution that is clear, colorless to yellow/orange, for intravenous injection only.  Each mL contains 10 mg rocuronium bromide and 2 mg sodium acetate.  The aqueous solution is adjusted to isotonicity with sodium chloride and to a pH of 4 with acetic acid and/or sodium hydroxide.



What does Rocuronium look like?



What are the available doses of Rocuronium?

Rocuronium Bromide Injection is available as

What should I talk to my health care provider before I take Rocuronium?

How should I use Rocuronium?

Rocuronium Bromide Injection is indicated for inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Rocuronium Bromide Injection is for intravenous use only.   

The dosage information which follows is derived from studies based upon units of drug per unit of body weight.  It is intended to serve as an initial guide to clinicians familiar with other neuromuscular blocking agents to acquire experience with Rocuronium Bromide Injection.

In patients in whom potentiation of, or resistance to, neuromuscular block is anticipated, a dose adjustment should be considered [ ].


What interacts with Rocuronium?

Sorry No Records found


What are the warnings of Rocuronium?

Sorry No Records found


What are the precautions of Rocuronium?

Sorry No Records found


What are the side effects of Rocuronium?

Sorry No records found


What should I look out for while using Rocuronium?

Rocuronium bromide is contraindicated in patients known to have hypersensitivity (e.g., anaphylaxis) to rocuronium bromide or other neuromuscular blocking agents [].


What might happen if I take too much Rocuronium?

Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia.  The primary treatment is maintenance of a patent airway, controlled ventilation, and adequate sedation until recovery of normal neuromuscular function is assured.  Once evidence of recovery from neuromuscular block is observed, further recovery may be facilitated by administration of an anticholinesterase agent in conjunction with an appropriate anticholinergic agent.

Anticholinesterase agents should not be administered prior to the demonstration of some spontaneous recovery from neuromuscular blockade.  The use of a nerve stimulator to document recovery is recommended.

Patients should be evaluated for adequate clinical evidence of neuromuscular recovery, e.g., 5-second head lift, adequate phonation, ventilation, and upper airway patency.  Ventilation must be supported while patients exhibit any signs of muscle weakness.

Recovery may be delayed in the presence of debilitation, carcinomatosis, and concomitant use of certain drugs which enhance neuromuscular blockade or separately cause respiratory depression.  Under such circumstances the management is the same as that of prolonged neuromuscular blockade.


How should I store and handle Rocuronium?

Store between 20° and 25°C (68° and 77°F) [see USP Controlled Room Temperature]. Keep container closed tightly. Protect from light.Rocuronium Bromide Injection is available in the following:The container closure is not made with natural rubber latex.Rocuronium Bromide Injection should be stored in a refrigerator, 2° to 8°C (36° to 46°F). DO NOT FREEZE.  Upon removal from refrigeration to room temperature storage conditions (25°C/77°F), use Rocuronium Bromide Injection within 60 days.  Use opened vials of Rocuronium Bromide Injection within 30 days. There is no specific work exposure limit for rocuronium bromide.  In case of eye contact, flush with water for at least 10 minutes.Rocuronium Bromide Injection is available in the following:The container closure is not made with natural rubber latex.Rocuronium Bromide Injection should be stored in a refrigerator, 2° to 8°C (36° to 46°F). DO NOT FREEZE.  Upon removal from refrigeration to room temperature storage conditions (25°C/77°F), use Rocuronium Bromide Injection within 60 days.  Use opened vials of Rocuronium Bromide Injection within 30 days. There is no specific work exposure limit for rocuronium bromide.  In case of eye contact, flush with water for at least 10 minutes.Rocuronium Bromide Injection is available in the following:The container closure is not made with natural rubber latex.Rocuronium Bromide Injection should be stored in a refrigerator, 2° to 8°C (36° to 46°F). DO NOT FREEZE.  Upon removal from refrigeration to room temperature storage conditions (25°C/77°F), use Rocuronium Bromide Injection within 60 days.  Use opened vials of Rocuronium Bromide Injection within 30 days. There is no specific work exposure limit for rocuronium bromide.  In case of eye contact, flush with water for at least 10 minutes.Rocuronium Bromide Injection is available in the following:The container closure is not made with natural rubber latex.Rocuronium Bromide Injection should be stored in a refrigerator, 2° to 8°C (36° to 46°F). DO NOT FREEZE.  Upon removal from refrigeration to room temperature storage conditions (25°C/77°F), use Rocuronium Bromide Injection within 60 days.  Use opened vials of Rocuronium Bromide Injection within 30 days. There is no specific work exposure limit for rocuronium bromide.  In case of eye contact, flush with water for at least 10 minutes.


×

Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Non-Clinical Toxicology
Rocuronium bromide is contraindicated in patients known to have hypersensitivity (e.g., anaphylaxis) to rocuronium bromide or other neuromuscular blocking agents [].

This drug may enhance the effects of: other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants, causing increased CNS depression

Rocuronium bromide should be administered in carefully adjusted dosages by or under the supervision of experienced clinicians who are familiar with the drug’s actions and the possible complications of its use.  The drug should not be administered unless facilities for intubation, mechanical ventilation, oxygen therapy, and an antagonist are immediately available.  It is recommended that clinicians administering neuromuscular blocking agents such as rocuronium bromide employ a peripheral nerve stimulator to monitor drug effect, need for additional doses, adequacy of spontaneous recovery or antagonism, and to decrease the complications of overdosage if additional doses are administered.

In clinical trials, the most common adverse reactions (2%) are transient hypotension and hypertension.

The following adverse reactions are described, or described in greater detail, in other sections:

×

Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

×

Review

Rate this treatment and share your opinion


Learn about User Reviews

Helpful tips to write a good review:

  1. Only share your first hand experience as a consumer or a care giver.
  2. Describe your experience in the Comments area including the benefits, side effects and how it has worked for you. Do not provide personal information like email addresses or telephone numbers.
  3. Fill in the optional information to help other users benefit from your review.

Reason for Taking This Treatment

(required)

Click the stars to rate this treatment

Effectiveness (required)

This medication has worked for me.




Ease of Use (required)

This medication has been easy for me to use.




Satisfaction (required)

Overall, I have been satisfied with my experience.




Write a brief description of your experience with this treatment:

2000 characters remaining

Optional Information

Help others benefit from your review by filling in the information below.
I am a:
Gender:
×

Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
×

Tips

Tips

×

Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).