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Rocuronium Bromide
Overview
What is Rocuronium Bromide?
Rocuronium bromide injection is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. Rocuronium bromide is chemically designated as 1-[17β-(acetyloxy)-3α-hydroxy-2β-(4-morpholinyl)-5α-androstan-16β-yl]-1-(2- propenyl)pyrrolidinium bromide.
The structural formula is:
The chemical formula is CHBrNO with a molecular weight of 609.70. The partition coefficient of rocuronium bromide in n-octanol/water is 0.5 at 20°C.
Rocuronium bromide is supplied as a sterile, nonpyrogenic, isotonic solution that is clear, colorless to yellow/orange, for intravenous injection only. Each mL contains 10 mg rocuronium bromide and 2 mg sodium acetate. The aqueous solution is adjusted to isotonicity with sodium chloride and to a pH of 4 with acetic acid and/or sodium hydroxide.
What does Rocuronium Bromide look like?
What are the available doses of Rocuronium Bromide?
Rocuronium bromide injection is available as
What should I talk to my health care provider before I take Rocuronium Bromide?
How should I use Rocuronium Bromide?
Rocuronium bromide injection is indicated for inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Rocuronium bromide injection is for intravenous use only.
The dosage information which follows is derived from studies based upon units of drug per unit of body weight. It is intended to serve as an initial guide to clinicians familiar with other neuromuscular blocking agents to acquire experience with rocuronium bromide.
In patients in whom potentiation of, or resistance to, neuromuscular block is anticipated, a dose adjustment should be considered
What interacts with Rocuronium Bromide?
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What are the warnings of Rocuronium Bromide?
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What are the precautions of Rocuronium Bromide?
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What are the side effects of Rocuronium Bromide?
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What should I look out for while using Rocuronium Bromide?
Rocuronium bromide is contraindicated in patients known to have hypersensitivity (e.g., anaphylaxis) to rocuronium bromide or other neuromuscular blocking agents .
What might happen if I take too much Rocuronium Bromide?
Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia. The primary treatment is maintenance of a patent airway, controlled ventilation, and adequate sedation until recovery of normal neuromuscular function is assured. Once evidence of recovery from neuromuscular block is observed, further recovery may be facilitated by administration of an anticholinesterase agent in conjunction with an appropriate anticholinergic agent.
Reversal of Neuromuscular Blockade:
Patients should be evaluated for adequate clinical evidence of neuromuscular recovery, e.g., 5- second head lift, adequate phonation, ventilation, and upper airway patency. Ventilation must be supported while patients exhibit any signs of muscle weakness.
Recovery may be delayed in the presence of debilitation, carcinomatosis, and concomitant use of certain drugs which enhance neuromuscular blockade or separately cause respiratory depression. Under such circumstances the management is the same as that of prolonged neuromuscular blockade.
How should I store and handle Rocuronium Bromide?
Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP].Rocuronium bromide injection is available in the following:50 mg/5 mL (10 mg/mL)100 mg/10 mL (10 mg/mL)Rocuronium bromide Injection should be stored in a refrigerator, 2° to 8°C (36° to 46°F). DO NOT FREEZE. Upon removal from refrigeration to room temperature storage conditions (25°C/77°F), use rocuronium bromide within 60 days. Use opened vials of rocuronium bromide within 30 days.Safety and Handling:Rocuronium bromide injection is available in the following:50 mg/5 mL (10 mg/mL)100 mg/10 mL (10 mg/mL)Rocuronium bromide Injection should be stored in a refrigerator, 2° to 8°C (36° to 46°F). DO NOT FREEZE. Upon removal from refrigeration to room temperature storage conditions (25°C/77°F), use rocuronium bromide within 60 days. Use opened vials of rocuronium bromide within 30 days.Safety and Handling:Rocuronium bromide injection is available in the following:50 mg/5 mL (10 mg/mL)100 mg/10 mL (10 mg/mL)Rocuronium bromide Injection should be stored in a refrigerator, 2° to 8°C (36° to 46°F). DO NOT FREEZE. Upon removal from refrigeration to room temperature storage conditions (25°C/77°F), use rocuronium bromide within 60 days. Use opened vials of rocuronium bromide within 30 days.Safety and Handling:Rocuronium bromide injection is available in the following:50 mg/5 mL (10 mg/mL)100 mg/10 mL (10 mg/mL)Rocuronium bromide Injection should be stored in a refrigerator, 2° to 8°C (36° to 46°F). DO NOT FREEZE. Upon removal from refrigeration to room temperature storage conditions (25°C/77°F), use rocuronium bromide within 60 days. Use opened vials of rocuronium bromide within 30 days.Safety and Handling:Rocuronium bromide injection is available in the following:50 mg/5 mL (10 mg/mL)100 mg/10 mL (10 mg/mL)Rocuronium bromide Injection should be stored in a refrigerator, 2° to 8°C (36° to 46°F). DO NOT FREEZE. Upon removal from refrigeration to room temperature storage conditions (25°C/77°F), use rocuronium bromide within 60 days. Use opened vials of rocuronium bromide within 30 days.Safety and Handling:
