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romidepsin
Overview
What is Romidepsin?
Romidepsin, a histone deacetylase (HDAC) inhibitor, is a bicyclic depsipeptide. At room temperature, romidepsin is a white powder and is described chemically as (1,4,7,10,16,21)-7-ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone. The empirical formula is CHNOS.
The molecular weight is 540.71 and the structural formula is:
Romidepsin for injection is intended for intravenous infusion only after reconstitution with the supplied diluent and after further dilution with 0.9% Sodium Chloride, USP.
Romidepsin is supplied as a kit containing 2 vials.
Romidepsin for injection is a sterile lyophilized white powder and is supplied in a 10 mg single-dose vial containing 11 mg romidepsin and 22 mg povidone, USP.
Diluent for romidepsin is a sterile clear solution and is supplied in a single-dose vial containing 2.4 mL (2.2 mL deliverable volume). Diluent for romidepsin contains
80% (v/v) propylene glycol, USP and 20% (v/v) dehydrated alcohol, USP.
What does Romidepsin look like?




What are the available doses of Romidepsin?
Romidepsin for Injection, 10 mg ().
What should I talk to my health care provider before I take Romidepsin?
How should I use Romidepsin?
Romidepsin is indicated for:
These indications are based on response rate. Clinical benefit such as improvement in overall survival has not been demonstrated.
The recommended dose of romidepsin is 14 mg/m administered intravenously over a 4-hour period on days 1, 8, and 15 of a 28-day cycle. Cycles should be repeated every 28 days provided that the patient continues to benefit from and tolerates the drug.
What interacts with Romidepsin?
Sorry No Records found
What are the warnings of Romidepsin?
Sorry No Records found
What are the precautions of Romidepsin?
Sorry No Records found
What are the side effects of Romidepsin?
Sorry No records found
What should I look out for while using Romidepsin?
None.
Catecholamine-depleting Drugs:
Digitalis Glycosides and Beta-blockers:
Calcium Channel Blockers:
CYP2D6 Inhibitors:
Hydralazine:
Alpha-adrenergic Agents:
Ergot Alkaloid:
Dipyridamole:
What might happen if I take too much Romidepsin?
No specific information is available on the treatment of overdosage of romidepsin.
Toxicities in a single-dose study in rats or dogs, at intravenous romidepsin doses up to 2.2 fold the recommended human dose based on the body surface area, included irregular respiration, irregular heartbeat, staggering gait, tremor, and tonic convulsions.
In the event of an overdose, it is reasonable to employ the usual supportive measures, e.g., clinical monitoring and supportive therapy, if required. There is no known antidote for romidepsin and it is not known if romidepsin is dialyzable.
How should I store and handle Romidepsin?
Romidepsin for Injection is supplied as a kit containing 2 vials in a single carton. The carton must be stored at 20° to 25°C, excursions permitted between 15° to 30°C. (See USP Controlled Room Temperature.)Procedures for proper handling and disposal of anticancer drugs should be considered. A guideline on this subject has been published Romidepsin for Injection is supplied as a kit containing 2 vials in a single carton. The carton must be stored at 20° to 25°C, excursions permitted between 15° to 30°C. (See USP Controlled Room Temperature.)Procedures for proper handling and disposal of anticancer drugs should be considered. A guideline on this subject has been published Metoprolol Tartrate Tablets, USP are available as follows: are pink round shaped, film coated tablets debossed with ‘C over 74’ on one side and deep break line on other side. Bottles of 30 NDC 68788-6446-3(Child Resistant Closure)Bottles of 60 NDC 68788-6446-6(Child Resistant Closure)Bottles of 100 NDC 68788-6446-1(Child Resistant Closure) in a tight, light-resistant container as defined in the USP using a child-resistant closure. Distributed by: 2400 Route 130 NorthDayton, NJ 08810 Manufactured by: Hyderabad-500 038, India Revised: 07/2017Repackaged By: Preferred Pharmaceuticals Inc. Metoprolol Tartrate Tablets, USP are available as follows: are pink round shaped, film coated tablets debossed with ‘C over 74’ on one side and deep break line on other side. Bottles of 30 NDC 68788-6446-3(Child Resistant Closure)Bottles of 60 NDC 68788-6446-6(Child Resistant Closure)Bottles of 100 NDC 68788-6446-1(Child Resistant Closure) in a tight, light-resistant container as defined in the USP using a child-resistant closure. Distributed by: 2400 Route 130 NorthDayton, NJ 08810 Manufactured by: Hyderabad-500 038, India Revised: 07/2017Repackaged By: Preferred Pharmaceuticals Inc. Metoprolol Tartrate Tablets, USP are available as follows: are pink round shaped, film coated tablets debossed with ‘C over 74’ on one side and deep break line on other side. Bottles of 30 NDC 68788-6446-3(Child Resistant Closure)Bottles of 60 NDC 68788-6446-6(Child Resistant Closure)Bottles of 100 NDC 68788-6446-1(Child Resistant Closure) in a tight, light-resistant container as defined in the USP using a child-resistant closure. Distributed by: 2400 Route 130 NorthDayton, NJ 08810 Manufactured by: Hyderabad-500 038, India Revised: 07/2017Repackaged By: Preferred Pharmaceuticals Inc. Metoprolol Tartrate Tablets, USP are available as follows: are pink round shaped, film coated tablets debossed with ‘C over 74’ on one side and deep break line on other side. Bottles of 30 NDC 68788-6446-3(Child Resistant Closure)Bottles of 60 NDC 68788-6446-6(Child Resistant Closure)Bottles of 100 NDC 68788-6446-1(Child Resistant Closure) in a tight, light-resistant container as defined in the USP using a child-resistant closure. Distributed by: 2400 Route 130 NorthDayton, NJ 08810 Manufactured by: Hyderabad-500 038, India Revised: 07/2017Repackaged By: Preferred Pharmaceuticals Inc. Metoprolol Tartrate Tablets, USP are available as follows: are pink round shaped, film coated tablets debossed with ‘C over 74’ on one side and deep break line on other side. Bottles of 30 NDC 68788-6446-3(Child Resistant Closure)Bottles of 60 NDC 68788-6446-6(Child Resistant Closure)Bottles of 100 NDC 68788-6446-1(Child Resistant Closure) in a tight, light-resistant container as defined in the USP using a child-resistant closure. Distributed by: 2400 Route 130 NorthDayton, NJ 08810 Manufactured by: Hyderabad-500 038, India Revised: 07/2017Repackaged By: Preferred Pharmaceuticals Inc.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Romidepsin is a histone deacetylase (HDAC) inhibitor. HDACs catalyze the removal of acetyl groups from acetylated lysine residues in histones, resulting in the modulation of gene expression. HDACs also deacetylate non-histone proteins, such as transcription factors. In vitro, romidepsin causes the accumulation of acetylated histones, and induces cell cycle arrest and apoptosis of some cancer cell lines with IC values in the nanomolar range. The mechanism of the antineoplastic effect of romidepsin observed in nonclinical and clinical studies has not been fully characterized.
Non-Clinical Toxicology
None.Array
Treatment with romidepsin can cause thrombocytopenia, leukopenia (neutropenia and lymphopenia), and anemia. Monitor blood counts regularly during treatment with romidepsin, and modify the dose as necessary
The following adverse reactions are described in more detail in other sections of the prescribing information.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
Review
Professional
Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
Tips
Interactions
Interactions
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