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SIMBRINZA
Overview
What is SIMBRINZA?
SIMBRINZA (brinzolamide/brimonidine tartrate ophthalmic suspension) 1%/0.2% is a fixed combination of a carbonic anhydrase inhibitor and an alpha 2 adrenergic receptor agonist.
Brinzolamide is described chemically as: (R)-(+)-4-Ethylamino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno [3,2-e]-1,2-thiazine-6-sulfonamide-1,1- dioxide. Its empirical formula is CHNOS, and its structural formula is:
Brinzolamide has a molecular weight of 383.5. It is a white powder, which is insoluble in water, very soluble in methanol and soluble in ethanol.
Brimonidine tartrate is described chemically as: 5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate. Its empirical formula of CHBrN – CHO and its structural formula is:
Brimonidine tartrate has a molecular weight of 442.2. It is a white to yellow powder that is soluble in water (34 mg/mL) at pH 6.5.
SIMBRINZA (brinzolamide/brimonidine tartrate ophthalmic suspension) 1%/0.2% is supplied as a sterile, aqueous suspension which has been formulated to be readily suspended following shaking. It has a pH of approximately 6.5 and an osmolality of approximately 270 mOsm/kg.
Each mL of SIMBRINZA (brinzolamide/brimonidine tartrate ophthalmic suspension) 1%/0.2% contains: brinzolamide 10 mg, brimonidine tartrate 2 mg (equivalent to 1.32 mg as brimonidine free base); benzalkonium chloride 0.03 mg; propylene glycol, carbomer 974P, boric acid, mannitol, sodium chloride, tyloxapol and purified water. Hydrochloric acid and/or sodium hydroxide may be added to adjust pH.
What does SIMBRINZA look like?






What are the available doses of SIMBRINZA?
Suspension containing 10 mg/mL brinzolamide and 2 mg/mL brimonidine tartrate.
What should I talk to my health care provider before I take SIMBRINZA?
How should I use SIMBRINZA?
SIMBRINZA (brinzolamide/brimonidine tartrate ophthalmic suspension) 1%/0.2% is a fixed combination of a carbonic anhydrase inhibitor and an alpha 2 adrenergic receptor agonist indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.
The recommended dose is one drop of SIMBRINZA in the affected eye(s) three times daily. Shake well before use. SIMBRINZA ophthalmic suspension may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. If more than one topical ophthalmic drug is being used, the drugs should be administered at least five (5) minutes apart.
What interacts with SIMBRINZA?
Sorry No Records found
What are the warnings of SIMBRINZA?
Sorry No Records found
What are the precautions of SIMBRINZA?
Sorry No Records found
What are the side effects of SIMBRINZA?
Sorry No records found
What should I look out for while using SIMBRINZA?
Hypersensitivity to any component of this product.
Neonates and infants (under the age of 2 years).
What might happen if I take too much SIMBRINZA?
Although no human data are available, electrolyte imbalance, development of an acidotic state, and possible nervous system effects may occur following an oral overdose of brinzolamide. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored.
Very limited information exists on accidental ingestion of brimonidine in adults; the only adverse event reported to date has been hypotension. Symptoms of brimonidine overdose have been reported in neonates, infants, and children receiving brimonidine as part of medical treatment of congenital glaucoma or by accidental oral ingestion. Treatment of an oral overdose includes supportive and symptomatic therapy; a patent airway should be maintained.
How should I store and handle SIMBRINZA?
Store original packages at room temperature; avoid excessive heat.SIMBRINZA (brinzolamide/brimonidine tartrate ophthalmic suspension) 1%/0.2% is supplied in white low density polyethylene (LDPE) DROP-TAINER bottles with a natural LDPE dispensing-tip and light green polypropylene cap as follows:8 mL in a 10 mL bottle NDC 0065-4147-27 Storage and HandlingStore SIMBRINZA at 2 - 25°C (36 - 77°F).SIMBRINZA (brinzolamide/brimonidine tartrate ophthalmic suspension) 1%/0.2% is supplied in white low density polyethylene (LDPE) DROP-TAINER bottles with a natural LDPE dispensing-tip and light green polypropylene cap as follows:8 mL in a 10 mL bottle NDC 0065-4147-27 Storage and HandlingStore SIMBRINZA at 2 - 25°C (36 - 77°F).SIMBRINZA (brinzolamide/brimonidine tartrate ophthalmic suspension) 1%/0.2% is supplied in white low density polyethylene (LDPE) DROP-TAINER bottles with a natural LDPE dispensing-tip and light green polypropylene cap as follows:8 mL in a 10 mL bottle NDC 0065-4147-27 Storage and HandlingStore SIMBRINZA at 2 - 25°C (36 - 77°F).SIMBRINZA (brinzolamide/brimonidine tartrate ophthalmic suspension) 1%/0.2% is supplied in white low density polyethylene (LDPE) DROP-TAINER bottles with a natural LDPE dispensing-tip and light green polypropylene cap as follows:8 mL in a 10 mL bottle NDC 0065-4147-27 Storage and HandlingStore SIMBRINZA at 2 - 25°C (36 - 77°F).