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Coccidioides immitis Spherule-Derived Skin Test Antigen

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Overview

What is Spherusol?

Spherusol is a sterile aqueous solution of extracts of spherules. The multi-dose vial contains 0.9% sodium chloride and 0.014% sodium borate with 0.4% phenol as a preservative. Residual thimerosal from the manufacturing process is present at a concentration of ≤0.0001% (
The potency of each lot of Spherusol is determined in sensitized guinea pigs.



What does Spherusol look like?



What are the available doses of Spherusol?

Spherusol is a solution for intradermal injection supplied in a 1 mL multi-dose vial. Each 0.1 mL dose contains 1.27 mcg of spherule-derived antigen.

What should I talk to my health care provider before I take Spherusol?

How should I use Spherusol?

Spherusol is a skin test antigen indicated for the detection of delayed-type hypersensitivity to in individuals with a history of pulmonary coccidioidomycosis. Spherusol is approved for use in individuals 18-64 years of age.

2.1 Preparation for Administration

Spherusol is a clear, colorless sterile solution for intradermal administration.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. If any of these conditions exists, the skin test antigen should not be administered.


What interacts with Spherusol?

Sorry No Records found


What are the warnings of Spherusol?

Sorry No Records found


What are the precautions of Spherusol?

Sorry No Records found


What are the side effects of Spherusol?

Sorry No records found


What should I look out for while using Spherusol?

A severe allergic reaction (e.g., anaphylaxis) to Spherusol , or any component of Spherusol or other coccidioidin products is a contraindication to administration.


What might happen if I take too much Spherusol?

Sorry No Records found


How should I store and handle Spherusol?

Store in a refrigerator 2° to 8°C (36° to 46°F).Spherusol is available in 1 mL multidose vial. NDC# 59584-140-01: multi-dose vial.Store refrigerated at 2° to 8°C (35° to 46°F). Do not freeze. Discard if frozen.Do not use after expiration date.Spherusol is available in 1 mL multidose vial. NDC# 59584-140-01: multi-dose vial.Store refrigerated at 2° to 8°C (35° to 46°F). Do not freeze. Discard if frozen.Do not use after expiration date.Spherusol is available in 1 mL multidose vial. NDC# 59584-140-01: multi-dose vial.Store refrigerated at 2° to 8°C (35° to 46°F). Do not freeze. Discard if frozen.Do not use after expiration date.Spherusol is available in 1 mL multidose vial. NDC# 59584-140-01: multi-dose vial.Store refrigerated at 2° to 8°C (35° to 46°F). Do not freeze. Discard if frozen.Do not use after expiration date.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Non-Clinical Toxicology
A severe allergic reaction (e.g., anaphylaxis) to Spherusol , or any component of Spherusol or other coccidioidin products is a contraindication to administration.

In patients who are receiving corticosteroids or immunosuppressive agents, reactivity to the test may be depressed or suppressed. This reduced reactivity may be present for as long as 5–6 weeks after discontinuation of therapy (see ).

The reactivity to PPD may be temporarily depressed by certain live virus vaccines (measles, mumps, rubella, oral polio, yellow fever, and varicella). Therefore, if a tuberculin test is to be performed, it should be administered either before the live vaccine or given simultaneously, but at a separate site than the live vaccine, or testing should be postponed for 4–6 weeks.

5.1 Prevention and Management of Acute Hypersensitivity Reactions

Prior to administration, the healthcare provider should review the medical history for possible skin test sensitivity and previous skin test related adverse reactions to assess the risks and benefits. Immediate hypersensitivity, to include severe systemic reactions, may occur following administration of skin test antigens. Medications and equipment to manage possible anaphylactic reactions should be available for immediate use. Patients should be observed for a minimum of 30 minutes following administration to assess for adverse reactions.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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