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Stalevo

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Overview

What is Stalevo?

Stalevo is a combination of carbidopa, levodopa, and entacapone for the treatment of Parkinson's disease.

Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. It is designated chemically as (-)-L-(α-hydrazino-(α-methyl-β-(3,4-dihydroxybenzene) propanoic acid monohydrate. Its empirical formula is CHNO∙HO, and its structural formula is:

Tablet content is expressed in terms of anhydrous carbidopa, which has a molecular weight of 226.3.

Levodopa, an aromatic amino acid, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 197.2. It is designated chemically as (-)-L-α-amino-β-(3,4-dihydroxybenzene) propanoic acid. Its empirical formula is CHNO, and its structural formula is:

Entacapone, a COMT inhibitor, is a nitro-catechol-structured compound with a molecular weight of 305.3. The chemical name of entacapone is (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide. Its empirical formula is CHNO and its structural formula is:

Stalevo is supplied as tablets in 6 strengths:

Stalevo 50:12.5 mg of carbidopa, 50 mg of levodopa and 200 mg of entacapone

Stalevo 75: 18.75 mg of carbidopa, 75 mg of levodopa and 200 mg of entacapone

Stalevo 100: 25 mg of carbidopa, 100 mg of levodopa and 200 mg of entacapone

Stalevo125: 31.25 mg of carbidopa, 125 mg of levodopa and 200 mg of entacapone

Stalevo 150: 37.5 mg of carbidopa, 150 mg of levodopa and 200 mg of entacapone

Stalevo 200: 50 mg of carbidopa, 200 mg of levodopa and 200 mg of entacapone

Inactive Ingredients:



What does Stalevo look like?



What are the available doses of Stalevo?

Each Stalevo tablet contains a 1:4 ratio of carbidopa to levodopa and 200 mg of entacapone (mg of carbidopa per mg of levodopa per mg of entacapone)

What should I talk to my health care provider before I take Stalevo?

How should I use Stalevo?

Stalevo, a combination drug consisting of levodopa, carbidopa (dopa decarboxylase inhibitor), and entacapone (catechol-O-methyltransferase-COMT inhibitor) is indicated for the treatment of Parkinson's disease.

Stalevo can be used:

Stalevo should be used as a substitute for patients already stabilized on equivalent doses of carbidopa/levodopa and entacapone. However, some patients who have been stabilized on a given dose of carbidopa/levodopa may be treated with Stalevo if a decision has been made to add entacapone (see below). Therapy should be individualized and adjusted according to the desired therapeutic response.


What interacts with Stalevo?

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What are the warnings of Stalevo?

Sorry No Records found


What are the precautions of Stalevo?

Sorry No Records found


What are the side effects of Stalevo?

Sorry No records found


What should I look out for while using Stalevo?

Stalevo is contraindicated in patients:

Potential for Sulfamethoxazole and Trimethoprim to Affect Other Drugs

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What might happen if I take too much Stalevo?


How should I store and handle Stalevo?

Storage ConditionsStore refrigerated between 2° and 8°C (36° and 46°F). Upon removal from refrigeration to room temperature storage conditions (25°C / 77°F), use Rocuronium Bromide Injection within 60 days. Use opened vials of Rocuronium Bromide Injection within 30 days. Do not freeze.Storage ConditionsStore refrigerated between 2° and 8°C (36° and 46°F). Upon removal from refrigeration to room temperature storage conditions (25°C / 77°F), use Rocuronium Bromide Injection within 60 days. Use opened vials of Rocuronium Bromide Injection within 30 days. Do not freeze.Storage ConditionsStore refrigerated between 2° and 8°C (36° and 46°F). Upon removal from refrigeration to room temperature storage conditions (25°C / 77°F), use Rocuronium Bromide Injection within 60 days. Use opened vials of Rocuronium Bromide Injection within 30 days. Do not freeze.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.Stalevo (carbidopa, levodopa and entacapone) is supplied as film-coated tablets for oral administration in the following six strengths:Stalevo 50The round, bi-convex shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 50" on one side.Stalevo 75The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 75" on one side.Stalevo 100The oval-shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 100" on one side.Stalevo 125The oval-shaped tablets are light brownish red, unscored and embossed with code "LCE 125" on one side.Stalevo 150The elongated-ellipse shaped tablets are brownish- or greyish-red, unscored, and embossed "LCE 150" on one side.Stalevo 200The oval shaped tablets are dark brownish red, unscored, and embossed "LCE 200" on one side.


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Non-Clinical Toxicology
Stalevo is contraindicated in patients:

Array

The following adverse reactions described in this section are related to at least one of the components of Stalevo (i.e., levodopa, carbidopa, and/or entacapone) based upon the safety experience in clinical trials (especially pivotal trials) or in postmarketing reports.

The following adverse reactions are discussed in more detail in the Warnings and Precautions sections of labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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