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Symbyax

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Overview

What is Symbyax?

SYMBYAX (olanzapine and fluoxetine HCl capsules) combines an atypical antipsychotic and a selective serotonin reuptake inhibitor, olanzapine (the active ingredient in Zyprexa, and Zyprexa Zydis) and fluoxetine hydrochloride (the active ingredient in Prozac, Prozac Weekly, and Sarafem).

Olanzapine belongs to the thienobenzodiazepine class. The chemical designation is 2-methyl-4-(4-methyl-1-piperazinyl)-10-thieno[2,] [1,5]benzodiazepine. The molecular formula is CHNS, which corresponds to a molecular weight of 312.44.

Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI). The chemical designation is (±)-N-methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine hydrochloride. The molecular formula is CHFNO•HCl, which corresponds to a molecular weight of 345.79.

The chemical structures are:

Olanzapine is a yellow crystalline solid, which is practically insoluble in water.

Fluoxetine hydrochloride is a white to off-white crystalline solid with a solubility of 14 mg/mL in water.

SYMBYAX capsules are available for oral administration in the following strength combinations:

Each capsule also contains pregelatinized starch, gelatin, dimethicone, titanium dioxide, sodium lauryl sulfate, edible black ink, red iron oxide, yellow iron oxide, and/or black iron oxide.



What does Symbyax look like?



What are the available doses of Symbyax?

Capsules (mg olanzapine/mg equivalent fluoxetine):

What should I talk to my health care provider before I take Symbyax?

How should I use Symbyax?

SYMBYAX is indicated for the treatment of:

Adult Starting Dose: 6 mg olanzapine with 25 mg fluoxetine (6 mg/25 mg, once daily in the evening (, )

Adult Maximum Dose: 12 mg/50 mg once daily (, ).

Pediatric Bipolar Depression Starting Dose: 3 mg/25 mg once daily (for ages 10 to 17 years) ().

Pediatric Bipolar Depression Maximum Dose: 12 mg/50 mg ()

Starting dose in patients predisposed to hypotensive reactions, hepatic impairment, or with potential for slowed metabolism: 3 mg/25 mg to 6 mg/25 mg . Escalate dose cautiously ()


What interacts with Symbyax?

Sorry No Records found


What are the warnings of Symbyax?

Sorry No Records found


What are the precautions of Symbyax?

Sorry No Records found


What are the side effects of Symbyax?

Sorry No records found


What should I look out for while using Symbyax?

Monoamine Oxidase Inhibitors (MAOI)

Pimozide

Thioridazine


What might happen if I take too much Symbyax?


How should I store and handle Symbyax?

Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature].Keep tightly closed and protect from moisture.Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature].Keep tightly closed and protect from moisture.Doxycycline hyclate capsules, USP is equivalent to doxycycline, USP and are supplied as hard gelatin capsules filled with yellow to light yellow powder having “AMNEAL” printed on light blue opaque cap and “1100” printed on light blue opaque body with black ink. They are available as follows: Bottles of 50:                          NDC 69238-1100-2 Bottles of 500:                        NDC 69238-1100-5 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Dispense in tight, light-resistant containers as defined in the USP. Doxycycline hyclate capsules, USP is equivalent to doxycycline, USP and are supplied as hard gelatin capsules filled with yellow to light yellow powder having “AMNEAL” printed on light blue opaque cap and “1100” printed on light blue opaque body with black ink. They are available as follows: Bottles of 50:                          NDC 69238-1100-2 Bottles of 500:                        NDC 69238-1100-5 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Dispense in tight, light-resistant containers as defined in the USP. Doxycycline hyclate capsules, USP is equivalent to doxycycline, USP and are supplied as hard gelatin capsules filled with yellow to light yellow powder having “AMNEAL” printed on light blue opaque cap and “1100” printed on light blue opaque body with black ink. They are available as follows: Bottles of 50:                          NDC 69238-1100-2 Bottles of 500:                        NDC 69238-1100-5 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Dispense in tight, light-resistant containers as defined in the USP.