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oseltamivir phosphate

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Overview

What is Tamiflu?

TAMIFLU (oseltamivir phosphate), an influenza neuraminidase inhibitor (NAI), is available as:

In addition to the active ingredient, each capsule contains croscarmellose sodium, povidone K30, pregelatinized starch, sodium stearyl fumarate and talc. The 30 mg capsule shell contains gelatin, red iron oxide, titanium dioxide, and yellow iron oxide. The 45 mg capsule shell contains black iron oxide, gelatin, and titanium dioxide. The 75 mg capsule shell contains black iron oxide, gelatin, red iron oxide, titanium dioxide, and yellow iron oxide. Each capsule is printed with blue ink, which includes FD&C Blue No. 2 as the colorant.

In addition to the active ingredient, the powder for oral suspension contains monosodium citrate, saccharin sodium, sodium benzoate, sorbitol, titanium dioxide, tutti-frutti flavoring, and xanthan gum.

Oseltamivir phosphate is a white crystalline solid with the chemical name (3R,4R,5S)-4-acetylamino-5-amino-3(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid, ethyl ester, phosphate (1:1). The chemical formula is C H N O (free base). The molecular weight is 312.4 for oseltamivir free base and 410.4 for oseltamivir phosphate salt. The structural formula is as follows:



What does Tamiflu look like?



What are the available doses of Tamiflu?

TAMIFLU Capsules:

TAMIFLU for Oral Suspension: 6 mg per mL (final concentration when constituted)

What should I talk to my health care provider before I take Tamiflu?

How should I use Tamiflu?

TAMIFLU is indicated for the treatment of acute, uncomplicated illness due to influenza A and B infection in patients 2 weeks of age and older who have been symptomatic for no more than 48 hours.

Administer TAMIFLU for the treatment of influenza in patients 2 weeks of age or older or for prophylaxis of influenza in patients 1 year and older using:

The capsules and oral suspension may be taken with or without food; however, tolerability may be enhanced if TAMIFLU is taken with food.

Adjust the TAMIFLU dosage in patients with moderate or severe renal impairment

For patients who cannot swallow capsules, TAMIFLU for oral suspension is the preferred formulation. When TAMIFLU for oral suspension is not available from wholesaler or the manufacturer, TAMIFLU capsules may be opened and mixed with sweetened liquids such as regular or sugar-free chocolate syrup, corn syrup, caramel topping, or light brown sugar (dissolved in water). During emergency situations when neither the oral suspension or the age-appropriate strengths of TAMIFLU capsules to mix with sweetened liquids are available, then a pharmacist may prepare an emergency supply of oral suspension from TAMIFLU 75 mg capsules


What interacts with Tamiflu?

Sorry No Records found


What are the warnings of Tamiflu?

Sorry No Records found


What are the precautions of Tamiflu?

Sorry No Records found


What are the side effects of Tamiflu?

Sorry No records found


What should I look out for while using Tamiflu?

TAMIFLU is contraindicated in patients with known serious hypersensitivity to oseltamivir or any component of the product. Severe allergic reactions have included anaphylaxis and serious skin reactions including toxic epidermal necrolysis, Stevens-Johnson Syndrome, and erythema multiforme .


What might happen if I take too much Tamiflu?

Reports of overdoses with TAMIFLU have been received from clinical trials and during postmarketing experience. In the majority of cases reporting overdose, no adverse reactions were reported. Adverse reactions reported following overdose were similar in nature to those observed with therapeutic doses of TAMIFLU .


How should I store and handle Tamiflu?

Store under refrigeration at 2°C to 8°C (36°F to 46°F). The product should not be stored at room temperature for more than 48 hours. Vials that develop particulate matter should not be used.Injection vials are single-dose only. After opening, any unused product should be discarded.Store under refrigeration at 2°C to 8°C (36°F to 46°F). The product should not be stored at room temperature for more than 48 hours. Vials that develop particulate matter should not be used.Injection vials are single-dose only. After opening, any unused product should be discarded.Cephalexin capsules, USP are available in500 mg CapsuleDark green opaque/light green opaque size “0” hard gelatin capsule filled with off white granular powder and imprinted with “A 43” on dark green opaque cap and “500 mg” on light green opaque body with black ink.Bottle of 12 – 68788-9404-1Bottle of 20 – 68788-9404-2Bottle of 21 – 68788-9404-7Bottle of 28 – 68788-9404-8Bottle of 30 – 68788-9404-3Bottle of 40 – 68788-9404-4Store atDispense in a tight, light-resistant container.Cephalexin capsules, USP are available in500 mg CapsuleDark green opaque/light green opaque size “0” hard gelatin capsule filled with off white granular powder and imprinted with “A 43” on dark green opaque cap and “500 mg” on light green opaque body with black ink.Bottle of 12 – 68788-9404-1Bottle of 20 – 68788-9404-2Bottle of 21 – 68788-9404-7Bottle of 28 – 68788-9404-8Bottle of 30 – 68788-9404-3Bottle of 40 – 68788-9404-4Store atDispense in a tight, light-resistant container.Cephalexin capsules, USP are available in500 mg CapsuleDark green opaque/light green opaque size “0” hard gelatin capsule filled with off white granular powder and imprinted with “A 43” on dark green opaque cap and “500 mg” on light green opaque body with black ink.Bottle of 12 – 68788-9404-1Bottle of 20 – 68788-9404-2Bottle of 21 – 68788-9404-7Bottle of 28 – 68788-9404-8Bottle of 30 – 68788-9404-3Bottle of 40 – 68788-9404-4Store atDispense in a tight, light-resistant container.Cephalexin capsules, USP are available in500 mg CapsuleDark green opaque/light green opaque size “0” hard gelatin capsule filled with off white granular powder and imprinted with “A 43” on dark green opaque cap and “500 mg” on light green opaque body with black ink.Bottle of 12 – 68788-9404-1Bottle of 20 – 68788-9404-2Bottle of 21 – 68788-9404-7Bottle of 28 – 68788-9404-8Bottle of 30 – 68788-9404-3Bottle of 40 – 68788-9404-4Store atDispense in a tight, light-resistant container.Cephalexin capsules, USP are available in500 mg CapsuleDark green opaque/light green opaque size “0” hard gelatin capsule filled with off white granular powder and imprinted with “A 43” on dark green opaque cap and “500 mg” on light green opaque body with black ink.Bottle of 12 – 68788-9404-1Bottle of 20 – 68788-9404-2Bottle of 21 – 68788-9404-7Bottle of 28 – 68788-9404-8Bottle of 30 – 68788-9404-3Bottle of 40 – 68788-9404-4Store atDispense in a tight, light-resistant container.Cephalexin capsules, USP are available in500 mg CapsuleDark green opaque/light green opaque size “0” hard gelatin capsule filled with off white granular powder and imprinted with “A 43” on dark green opaque cap and “500 mg” on light green opaque body with black ink.Bottle of 12 – 68788-9404-1Bottle of 20 – 68788-9404-2Bottle of 21 – 68788-9404-7Bottle of 28 – 68788-9404-8Bottle of 30 – 68788-9404-3Bottle of 40 – 68788-9404-4Store atDispense in a tight, light-resistant container.Cephalexin capsules, USP are available in500 mg CapsuleDark green opaque/light green opaque size “0” hard gelatin capsule filled with off white granular powder and imprinted with “A 43” on dark green opaque cap and “500 mg” on light green opaque body with black ink.Bottle of 12 – 68788-9404-1Bottle of 20 – 68788-9404-2Bottle of 21 – 68788-9404-7Bottle of 28 – 68788-9404-8Bottle of 30 – 68788-9404-3Bottle of 40 – 68788-9404-4Store atDispense in a tight, light-resistant container.Cephalexin capsules, USP are available in500 mg CapsuleDark green opaque/light green opaque size “0” hard gelatin capsule filled with off white granular powder and imprinted with “A 43” on dark green opaque cap and “500 mg” on light green opaque body with black ink.Bottle of 12 – 68788-9404-1Bottle of 20 – 68788-9404-2Bottle of 21 – 68788-9404-7Bottle of 28 – 68788-9404-8Bottle of 30 – 68788-9404-3Bottle of 40 – 68788-9404-4Store atDispense in a tight, light-resistant container.Cephalexin capsules, USP are available in500 mg CapsuleDark green opaque/light green opaque size “0” hard gelatin capsule filled with off white granular powder and imprinted with “A 43” on dark green opaque cap and “500 mg” on light green opaque body with black ink.Bottle of 12 – 68788-9404-1Bottle of 20 – 68788-9404-2Bottle of 21 – 68788-9404-7Bottle of 28 – 68788-9404-8Bottle of 30 – 68788-9404-3Bottle of 40 – 68788-9404-4Store atDispense in a tight, light-resistant container.Cephalexin capsules, USP are available in500 mg CapsuleDark green opaque/light green opaque size “0” hard gelatin capsule filled with off white granular powder and imprinted with “A 43” on dark green opaque cap and “500 mg” on light green opaque body with black ink.Bottle of 12 – 68788-9404-1Bottle of 20 – 68788-9404-2Bottle of 21 – 68788-9404-7Bottle of 28 – 68788-9404-8Bottle of 30 – 68788-9404-3Bottle of 40 – 68788-9404-4Store atDispense in a tight, light-resistant container.Cephalexin capsules, USP are available in500 mg CapsuleDark green opaque/light green opaque size “0” hard gelatin capsule filled with off white granular powder and imprinted with “A 43” on dark green opaque cap and “500 mg” on light green opaque body with black ink.Bottle of 12 – 68788-9404-1Bottle of 20 – 68788-9404-2Bottle of 21 – 68788-9404-7Bottle of 28 – 68788-9404-8Bottle of 30 – 68788-9404-3Bottle of 40 – 68788-9404-4Store atDispense in a tight, light-resistant container.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Oseltamivir is an antiviral drug with activity against influenza virus

Non-Clinical Toxicology
TAMIFLU is contraindicated in patients with known serious hypersensitivity to oseltamivir or any component of the product. Severe allergic reactions have included anaphylaxis and serious skin reactions including toxic epidermal necrolysis, Stevens-Johnson Syndrome, and erythema multiforme .

Concomitant topical medication, medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices or lime should be used with caution because of possible interaction with tretinoin. Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid with tretinoin. It also is advisable to “rest” a patient’s skin until the effects of such preparations subside before use of tretinoin is begun.

Cases of anaphylaxis and serious skin reactions including toxic epidermal necrolysis, Stevens-Johnson Syndrome, and erythema multiforme have been reported in postmarketing experience with TAMIFLU. Stop TAMIFLU and institute appropriate treatment if an allergic-like reaction occurs or is suspected. The use of TAMIFLU is contraindicated in patients with known serious hypersensitivity to TAMIFLU .

The following serious adverse reactions are discussed below and elsewhere in the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).