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Tamsulosin Hydrochloride

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Overview

What is Tamsulosin Hydrochloride?

Tamsulosin hydrochloride is an antagonist of alpha adrenoceptors in the prostate.

Tamsulosin hydrochloride is (-)-()-5-[2-[[2-(-Ethoxyphenoxy) ethyl]amino]propyl]-2-methoxybenzenesulfonamide, monohydrochloride. Tamsulosin hydrochloride, USP is a white crystalline powder that melts with decomposition at approximately 230°C.  It is sparingly soluble in water and methanol, slightly soluble in glacial acetic acid and ethanol, and practically insoluble in ether.

The molecular formula of tamsulosin hydrochloride is CHNOS • HCl. The molecular weight of tamsulosin hydrochloride is 444.98. Its structural formula is:  

Each tamsulosin hydrochloride capsule intended for oral administration contains tamsulosin hydrochloride 0.4 mg. In addition, each capsule contains the following inactive ingredients: black iron oxide, D&C yellow # 10, FD&C blue # 1, FD&C red # 40, FD&C yellow # 6, gelatin, methacrylic acid copolymer dispersion, microcrystalline cellulose, polysorbate 80, talc, titanium dioxide, triacetin and yellow iron oxide. The capsule is printed with black pharmaceutical ink which contains black iron oxide as a coloring agent.



What does Tamsulosin Hydrochloride look like?



What are the available doses of Tamsulosin Hydrochloride?

Capsule: 0.4 mg, white to off-white free flowing pellets filled in size ‘2’ empty hard gelatin capsules with green colored cap printed with "ZA-18" in black ink and peach colored body printed with "0.4 mg" in black ink

What should I talk to my health care provider before I take Tamsulosin Hydrochloride?

How should I use Tamsulosin Hydrochloride?

0.4 mg once daily taken approximately one-half hour following the same meal each day ()

Can be increased to 0.8 mg once daily for patients who fail to respond to the 0.4 mg dose after 2 to 4 weeks of dosing ()

If discontinued or interrupted for several days, therapy should start again with the 0.4 mg once-daily dose ()


What interacts with Tamsulosin Hydrochloride?

Sorry No Records found


What are the warnings of Tamsulosin Hydrochloride?

Sorry No Records found


What are the precautions of Tamsulosin Hydrochloride?

Sorry No Records found


What are the side effects of Tamsulosin Hydrochloride?

Sorry No records found


What should I look out for while using Tamsulosin Hydrochloride?

Contraindicated in patients known to be hypersensitive to tamsulosin hydrochloride or any component of tamsulosin hydrochloride capsules (, )


What might happen if I take too much Tamsulosin Hydrochloride?

Should overdosage of tamsulosin hydrochloride capsules lead to hypotension [see and support of the cardiovascular system is of first importance.  Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position. If this measure is inadequate, then administration of intravenous fluids should be considered. If necessary, vasopressors should then be used and renal function should be monitored and supported as needed. Laboratory data indicate that tamsulosin hydrochloride is 94% to 99% protein bound; therefore, dialysis is unlikely to be of benefit.


How should I store and handle Tamsulosin Hydrochloride?

Procedures for proper handling and disposal should be considered. Consideration should be given to handling and disposal according to guidelines issued for cytotoxic drugs. Several guidelines on this subject have been published. Caution should be exercised in the handling and preparation of Fludarabine Phosphate Injection solution. The use of latex gloves and safety glasses is recommended to avoid exposure in case of breakage of the vial or other accidental spillage. If the solution contacts the skin or mucous membranes, wash thoroughly with soap and water; rinse eyes thoroughly with plain water. Avoid exposure by inhalation or by direct contact of the skin or mucous membranes.Tamsulosin Hydrochloride Capsules USP, 0.4 mg are white to off-white free flowing pellets filled in size ‘2’ empty hard gelatin capsules with green colored cap printed with "ZA-18" in black ink and peach colored body printed with "0.4 mg" in black ink and are supplied as follows: NDC 67046-720-30 in blister of 30 capsulesStorage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight container.Keep tamsulosin hydrochloride capsules and all medicines out of reach of children. Tamsulosin Hydrochloride Capsules USP, 0.4 mg are white to off-white free flowing pellets filled in size ‘2’ empty hard gelatin capsules with green colored cap printed with "ZA-18" in black ink and peach colored body printed with "0.4 mg" in black ink and are supplied as follows: NDC 67046-720-30 in blister of 30 capsulesStorage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight container.Keep tamsulosin hydrochloride capsules and all medicines out of reach of children. Tamsulosin Hydrochloride Capsules USP, 0.4 mg are white to off-white free flowing pellets filled in size ‘2’ empty hard gelatin capsules with green colored cap printed with "ZA-18" in black ink and peach colored body printed with "0.4 mg" in black ink and are supplied as follows: NDC 67046-720-30 in blister of 30 capsulesStorage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight container.Keep tamsulosin hydrochloride capsules and all medicines out of reach of children. Tamsulosin Hydrochloride Capsules USP, 0.4 mg are white to off-white free flowing pellets filled in size ‘2’ empty hard gelatin capsules with green colored cap printed with "ZA-18" in black ink and peach colored body printed with "0.4 mg" in black ink and are supplied as follows: NDC 67046-720-30 in blister of 30 capsulesStorage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight container.Keep tamsulosin hydrochloride capsules and all medicines out of reach of children. Tamsulosin Hydrochloride Capsules USP, 0.4 mg are white to off-white free flowing pellets filled in size ‘2’ empty hard gelatin capsules with green colored cap printed with "ZA-18" in black ink and peach colored body printed with "0.4 mg" in black ink and are supplied as follows: NDC 67046-720-30 in blister of 30 capsulesStorage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight container.Keep tamsulosin hydrochloride capsules and all medicines out of reach of children. Tamsulosin Hydrochloride Capsules USP, 0.4 mg are white to off-white free flowing pellets filled in size ‘2’ empty hard gelatin capsules with green colored cap printed with "ZA-18" in black ink and peach colored body printed with "0.4 mg" in black ink and are supplied as follows: NDC 67046-720-30 in blister of 30 capsulesStorage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight container.Keep tamsulosin hydrochloride capsules and all medicines out of reach of children.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

The symptoms associated with benign prostatic hyperplasia are related to bladder outlet obstruction, which is comprised of two underlying components: static and dynamic. The static component is related to an increase in prostate size caused, in part, by a proliferation of smooth muscle cells in the prostatic stroma.  However, the severity of BPH symptoms and the degree of urethral obstruction do not correlate well with the size of the prostate. The dynamic component is a function of an increase in smooth muscle tone in the prostate and bladder neck leading to constriction of the bladder outlet.  Smooth muscle tone is mediated by the sympathetic nervous stimulation of alpha adrenoceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck.  Blockade of these adrenoceptors can cause smooth muscles in the bladder neck and prostate to relax, resulting in an improvement in urine flow rate and a reduction in symptoms of BPH.

Tamsulosin, an alpha adrenoceptor blocking agent, exhibits selectivity for alpha receptors in the human prostate.  At least three discrete alpha adrenoceptor subtypes have been identified:  alpha, alpha, and alpha; their distribution differs between human organs and tissue. Approximately 70% of the alpha receptors in human prostate are of the alpha subtype.

Tamsulosin hydrochloride capsules are not intended for use as an antihypertensive drug.

Non-Clinical Toxicology
Contraindicated in patients known to be hypersensitive to tamsulosin hydrochloride or any component of tamsulosin hydrochloride capsules (, )

As adapalene gel has the potential to produce local irritation in some patients, concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices, or lime) should be approached with caution. Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid in combination with adapalene gel. If these preparations have been used, it is advisable not to start therapy with adapalene gel until the effects of such preparations in the skin have subsided.

The signs and symptoms of orthostasis (postural hypotension, dizziness and vertigo) were detected more frequently in tamsulosin hydrochloride capsule-treated patients than in placebo recipients.  As with other alpha adrenergic blocking agents there is a potential risk of syncope [see Patients beginning treatment with tamsulosin hydrochloride capsules should be cautioned to avoid situations where injury could result should syncope occur [see

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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