Telmisartan and Hydrochlorothiazide

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Overview

What is Telmisartan and Hydrochlorothiazide?

Telmisartan and hydrochlorothiazide tablets USP are a combination of telmisartan, an orally active angiotensin II antagonist acting on the AT receptor subtype, and hydrochlorothiazide, a thiazide diuretic.

Telmisartan, a non-peptide molecule, is chemically described as 4'-[(1, 4'-dimethyl-2'-propyl[2,6'-bi-1-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid. Its empirical formula is CHNO, its molecular weight is 514.63, and its structural formula is:

Telmisartan is a white to slightly yellowish solid. It is practically insoluble in water and in the pH range of 3 to 9, sparingly soluble in strong acid (except insoluble in hydrochloric acid), and soluble in strong base.

Hydrochlorothiazide is a white, or practically white, practically odorless, crystalline powder with a molecular weight of 297.74. It is slightly soluble in water, and freely soluble in sodium hydroxide solution. Hydrochlorothiazide is chemically described as 6-chloro-3,4-dihydro-2-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is CHClNOS, and its structural formula is:

Telmisartan and hydrochlorothiazide tablets USP are formulated for oral administration in three combinations of 40 mg/12.5 mg, 80 mg/12.5 mg, and 80 mg/25 mg telmisartan and hydrochlorothiazide, respectively. The tablets contain the following inactive ingredients: crosscarmalose sodium, lactose monohydrate, magnesium stearate, povidone and sodium hydroxide. As coloring agents, the 40 mg/12.5 mg and 80 mg/12.5 mg tablets contain red iron oxide, and the 80 mg/25 mg tablets contain yellow iron oxide.

What does Telmisartan and Hydrochlorothiazide look like?

What are the available doses of Telmisartan and Hydrochlorothiazide?

Tablets: 40 mg/12.5 mg, 80 mg/12.5 mg, 80 mg/25 mg ()

What should I talk to my health care provider before I take Telmisartan and Hydrochlorothiazide?

How should I use Telmisartan and Hydrochlorothiazide?

Telmisartan and hydrochlorothiazide tablets are combination of an angiotensin II receptor blocker (ARB) and a thiazide diuretic indicated for the treatment of hypertension, alone or with other antihypertensive agents, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions ()

Telmisartan and hydrochlorothiazide tablets are not indicated for initial therapy ()

Usual starting dose is 80 mg/12.5 mg once daily ()

Titrate up to 160 mg/25 mg as needed ()

Initiate patients with biliary obstructive disorders or hepatic insufficiency at 40 mg/12.5 mg ()

What interacts with Telmisartan and Hydrochlorothiazide?

Sorry No Records found

What are the warnings of Telmisartan and Hydrochlorothiazide?

Sorry No Records found

What are the precautions of Telmisartan and Hydrochlorothiazide?

Sorry No Records found

What are the side effects of Telmisartan and Hydrochlorothiazide?

Sorry No records found

What should I look out for while using Telmisartan and Hydrochlorothiazide?

Hypersensitivity to telmisartan or any component ()

Anuria ()

Co-Administration with aliskiren in patients with diabetes ()

What might happen if I take too much Telmisartan and Hydrochlorothiazide?

Telmisartan

Limited data are available with regard to overdosage of telmisartan in humans. The most likely manifestations of overdosage with telmisartan are hypotension, dizziness, and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation. If symptomatic hypotension should occur, supportive treatment should be instituted. Telmisartan is not removed by hemodialysis.

Hydrochlorothiazide

The most common signs and symptoms observed in patients with a hydrochlorothiazide overdose are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. The degree to which hydrochlorothiazide is removed by hemodialysis has not been established. The oral LD of hydrochlorothiazide is greater than 10 g/kg in both mice and rats.

How should I store and handle Telmisartan and Hydrochlorothiazide?

StorageStore Pantoprazole Sodium Delayed-Release Tablets, USP at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) []. StorageStore Pantoprazole Sodium Delayed-Release Tablets, USP at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) []. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Telmisartan and Hydrochlorothiazide Tablets USP are available in three strengths:40 mg/12.5 mg: supplied as oval shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M31' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-193-06Bottle of 90's: NDC 68180-193-09Unit Dose Blisters of 3 X 10s NDC 68180-193-1380 mg/12.5 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is red coloured and telmisartan layer is white to off-white in colour but may have red specks; debossed with 'M32' on one side and 'LU' on other side.Bottle of 30's: NDC 68180-194-06Bottle of 90's: NDC 68180-194-09Unit Dose Blisters of 3 X 10s NDC 68180-194-1380 mg/25 mg: supplied as capsule shaped, biconvex, bilayer, uncoated tablets; where hydrochlorothiazide layer is yellow coloured and telmisartan layer is white to off-white in colour but may have yellow specks; debossed with 'M33' on one side and 'LU' on other side. Bottle of 30's: NDC 68180-195-06Bottle of 90's: NDC 68180-195-09Unit Dose Blisters of 3 X 10s NDC 68180-195-13StorageStore at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature].

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Clinical Information

Chemical Structure

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Clinical Pharmacology

Telmisartan and hydrochlorothiazide tablets are a combination of two drugs with antihypertensive properties: a thiazide diuretic, hydrochlorothiazide, and an angiotensin II receptor blocker (ARB), telmisartan.

Telmisartan:

Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis.

There is also an AT receptor found in many tissues, but AT is not known to be associated with cardiovascular homeostasis. Telmisartan has much greater affinity (>3,000-fold) for the AT receptor than for the AT receptor.

Telmisartan does not inhibit ACE (kininase II) nor does it bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.

Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of telmisartan on blood pressure.

Hydrochlorothiazide:

Hydrochlorothiazide is a thiazide diuretic. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium salt and chloride in approximately equivalent amounts. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so co-administration of an ARB tends to reverse the potassium loss associated with these diuretics. The mechanism of the antihypertensive effect of thiazides is not fully understood.

Non-Clinical Toxicology

Hypersensitivity to telmisartan or any component ()

Anuria ()

Co-Administration with aliskiren in patients with diabetes ()

Reports of INR increase with the use of warfarin have been observed. It is recommended that INR levels be monitored in patients on warfarin therapy after the initiation of treatment with levocarnitine or after dose adjustments.

Avoid fetal or neonatal exposure ()

Correct volume or salt depletion before initiating therapy. Observe for signs and symptoms of hypotension ()

Monitor renal function and potassium in susceptible patients ()

Observe for clinical signs of fluid or electrolyte imbalance ()

Hypersensitivity Reaction ()

Acute Myopia and Secondary Angle-Closure Glaucoma ()

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Review

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

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Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

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