Disclaimer:
Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.
Thymoglobulin
Overview
What is Thymoglobulin?
THYMOGLOBULIN (anti-thymocyte globulin [rabbit]) is a purified, pasteurized, immunoglobulin G, obtained by immunization of rabbits with human thymocytes. This immunosuppressive product contains cytotoxic antibodies directed against antigens expressed on human T-lymphocytes.
THYMOGLOBULIN is a sterile, lyophilized powder for intravenous administration after reconstitution with sterile Water for Injection, USP (SWFI). Each single-use 10 mL vial contains 25 mg of anti-thymocyte globulin (rabbit), 50 mg glycine, 10 mg sodium chloride, and 50 mg mannitol.
After reconstitution with 5 mL SWFI, each vial of reconstituted product contains approximately 5 mg/mL of THYMOGLOBULIN, of which >90% is rabbit gamma immune globulin (IgG). The reconstituted solution has a pH of 6.5 to 7.2.
Human red blood cells are used in the manufacturing process to deplete cross-reactive antibodies to non–T-cell antigens. The manufacturing process is validated to remove or inactivate potential exogenous viruses. All human red blood cells are from U.S.-registered or FDA-licensed blood banks. A virus removal step (nanofiltration, using a 20 nm filter) and a viral inactivation step (pasteurization, i.e., heat treatment of active ingredient at 60°C/10 hr) are performed for each lot. Each THYMOGLOBULIN lot is released following potency testing (lymphocytotoxicity and E-rosette inhibition assays), and cross-reactive antibody testing (hemagglutination, platelet agglutination, antiglomerular basement membrane antibody, and fibroblast toxicity assays on every lot).
What does Thymoglobulin look like?
What are the available doses of Thymoglobulin?
THYMOGLOBULIN for injection: 25 mg anti-thymocyte globulin (rabbit) as a sterile lyophilized powder, in single-use 10 mL vials for reconstitution.
What should I talk to my health care provider before I take Thymoglobulin?
How should I use Thymoglobulin?
THYMOGLOBULIN is indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant. THYMOGLOBULIN is to be used in conjunction with concomitant immunosuppression.
THYMOGLOBULIN is intended for intravenous use only.
What interacts with Thymoglobulin?
Sorry No Records found
What are the warnings of Thymoglobulin?
Sorry No Records found
What are the precautions of Thymoglobulin?
Sorry No Records found
What are the side effects of Thymoglobulin?
Sorry No records found
What should I look out for while using Thymoglobulin?
THYMOGLOBULIN is contraindicated in patients with history of allergy or anaphylactic reaction to rabbit proteins or to any product excipients, or who have active acute or chronic infections that contraindicate any additional immunosuppression .
THYMOGLOBULIN should only be used by physicians experienced in immunosuppressive therapy in transplantation
[see ]
.
What might happen if I take too much Thymoglobulin?
THYMOGLOBULIN overdosage may result in leukopenia (including lymphopenia and neutropenia) and/ or thrombocytopenia, which can be managed with dose reduction .
How should I store and handle Thymoglobulin?
Hydrochlorothiazide tablets, USP are available containing 12.5 mg, 25 mg and 50 mg hydrochlorothiazide, USP.The 12.5 mg tablets are light orange to peach colored, round, biconvex tablets debossed with H on one side and 1 on another side. They are available as follows:55700-473-90The 25 mg tablets are light orange to peach colored, round, flat tablets with beveled edges and debossed with H & 2 on either side of break line and another side is plain. They are available as follows:The 50 mg tablets are light orange to peach colored, round, flat tablets with beveled edges and debossed with H & 3 on either side of break line and another side is plain. They are available as follows:Hydrochlorothiazide tablets, USP are available containing 12.5 mg, 25 mg and 50 mg hydrochlorothiazide, USP.The 12.5 mg tablets are light orange to peach colored, round, biconvex tablets debossed with H on one side and 1 on another side. They are available as follows:55700-473-90The 25 mg tablets are light orange to peach colored, round, flat tablets with beveled edges and debossed with H & 2 on either side of break line and another side is plain. They are available as follows:The 50 mg tablets are light orange to peach colored, round, flat tablets with beveled edges and debossed with H & 3 on either side of break line and another side is plain. They are available as follows:Hydrochlorothiazide tablets, USP are available containing 12.5 mg, 25 mg and 50 mg hydrochlorothiazide, USP.The 12.5 mg tablets are light orange to peach colored, round, biconvex tablets debossed with H on one side and 1 on another side. They are available as follows:55700-473-90The 25 mg tablets are light orange to peach colored, round, flat tablets with beveled edges and debossed with H & 2 on either side of break line and another side is plain. They are available as follows:The 50 mg tablets are light orange to peach colored, round, flat tablets with beveled edges and debossed with H & 3 on either side of break line and another side is plain. They are available as follows:Hydrochlorothiazide tablets, USP are available containing 12.5 mg, 25 mg and 50 mg hydrochlorothiazide, USP.The 12.5 mg tablets are light orange to peach colored, round, biconvex tablets debossed with H on one side and 1 on another side. They are available as follows:55700-473-90The 25 mg tablets are light orange to peach colored, round, flat tablets with beveled edges and debossed with H & 2 on either side of break line and another side is plain. They are available as follows:The 50 mg tablets are light orange to peach colored, round, flat tablets with beveled edges and debossed with H & 3 on either side of break line and another side is plain. They are available as follows:Hydrochlorothiazide tablets, USP are available containing 12.5 mg, 25 mg and 50 mg hydrochlorothiazide, USP.The 12.5 mg tablets are light orange to peach colored, round, biconvex tablets debossed with H on one side and 1 on another side. They are available as follows:55700-473-90The 25 mg tablets are light orange to peach colored, round, flat tablets with beveled edges and debossed with H & 2 on either side of break line and another side is plain. They are available as follows:The 50 mg tablets are light orange to peach colored, round, flat tablets with beveled edges and debossed with H & 3 on either side of break line and another side is plain. They are available as follows:
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
The mechanism of action by which polyclonal antilymphocyte preparations suppress immune responses is not fully understood. Possible mechanisms by which THYMOGLOBULIN may induce immunosuppression include: T-cell clearance from the circulation and modulation of T-cell activation, homing, and cytotoxic activities. THYMOGLOBULIN includes antibodies against T-cell markers such as CD2, CD3, CD4, CD8, CD11a, CD18, CD25, CD44, CD45, HLA-DR, HLA Class I heavy chains, and ß2 micro-globulin. , THYMOGLOBULIN (concentrations >0.1 mg/mL) mediates T-cell suppressive effects via inhibition of proliferative responses to several mitogens. In patients, T-cell depletion is usually observed within a day after initiating THYMOGLOBULIN therapy.
THYMOGLOBULIN has not been shown to be effective for treating antibody-mediated (humoral) rejections.
Non-Clinical Toxicology
THYMOGLOBULIN is contraindicated in patients with history of allergy or anaphylactic reaction to rabbit proteins or to any product excipients, or who have active acute or chronic infections that contraindicate any additional immunosuppression .THYMOGLOBULIN should only be used by physicians experienced in immunosuppressive therapy in transplantation
[see ]
.
When given concurrently the following drugs may interact with thiazide diuretics.
To prevent over-immunosuppression, physicians may wish to decrease the dose of the maintenance immunosuppression regimen during the period of THYMOGLOBULIN use.
Dosing for THYMOGLOBULIN is different from dosing for other ATG products, because protein composition and concentrations vary depending on the source of ATG. The prescribing physician must ensure that the dose prescribed is appropriate for the anti-thymocyte globulin (ATG) product being administered.
The most common adverse reactions and laboratory abnormalities (incidence >5% higher than comparator) are urinary tract infection, abdominal pain, hypertension, nausea, shortness of breath, fever, headache, anxiety, chills, increased potassium levels in the blood, and low counts of platelets and white blood cells.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
Review
Read user comments about the side effects, benefits, and effectiveness of losartan oral.
Overall User Ratings
516Total User Reviews
User Reviews
Learn about
User Reviews
Professional
Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
Tips
Interactions
Interactions
A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).