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Tirosint
Overview
What is Tirosint?
TIROSINT (levothyroxine sodium) capsules for oral use contain synthetic L-3,3',5,5'-tetraiodothyronine sodium salt [levothyroxine (T) sodium]. Synthetic T4 is chemically identical to that produced in the human thyroid gland. Levothyroxine (T4) sodium has an empirical formula of CHINNaO • x HO (where x = 5), molecular weight of 798.86 g/mol (anhydrous), and structural formula as shown:
TIROSINT (levothyroxine sodium) capsules are amber-colored, round/biconvex capsules containing a viscous amber-colored liquid.
The inactive ingredients in TIROSINT are gelatin, glycerin and water.
What does Tirosint look like?
What are the available doses of Tirosint?
Capsules: 13, 25, 50, 75, 88, 100, 112, 125, 137, 150, 175, 200 mcg ()
What should I talk to my health care provider before I take Tirosint?
Pregnancy may require the use of higher doses of TIROSINT (, )
How should I use Tirosint?
Hypothyroidism
TIROSINT is indicated as a replacement therapy in adults and pediatric patients 6 years and older with primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism.
Administer TIROSINT as a single daily oral dose, on an empty stomach, one-half to one hour before breakfast.
Administer TIROSINT at least 4 hours before or after drugs known to interfere with TIROSINT absorption
Evaluate the need for dose adjustments when regularly administering within an hour of certain foods that may affect TIROSINT absorption
Swallow TIROSINT capsules whole, do not cut or crush capsules.
What interacts with Tirosint?
Sorry No Records found
What are the warnings of Tirosint?
Sorry No Records found
What are the precautions of Tirosint?
Sorry No Records found
What are the side effects of Tirosint?
Sorry No records found
What should I look out for while using Tirosint?
TIROSINT is contraindicated in patients with uncorrected adrenal insufficiency
What might happen if I take too much Tirosint?
The signs and symptoms of overdosage are those of hyperthyroidism In addition, confusion and disorientation may occur. Cerebral embolism, shock, coma, and death have been reported. Seizures occurred in a 3-year-old child ingesting 3.6 mg of levothyroxine. Symptoms may not necessarily be evident or may not appear until several days after ingestion of levothyroxine sodium.
Reduce the TIROSINT dose or discontinue temporarily if signs or symptoms of overdosage occur. Initiate appropriate supportive treatment as dictated by the patient's medical status.
For current information on the management of poisoning or overdosage, contact the National Poison Control Center at 1-800-222-1222 or www.poison.org.
How should I store and handle Tirosint?
Store at 25°C (77°F); excursions permitted to 15°-30°C (59-86°F) [see USP Controlled Room Temperature]. TIROSINT capsules should be protected from heat, light and moisture.Do not separate the individual cavities containing the drug from the intact blister as important information may be lost (i.e., manufacturer/distributor names, distributor contact phone number, lot number, and expiration date), and do not remove the individual capsules from blister packaging until ready to use.Store at 25°C (77°F); excursions permitted to 15°-30°C (59-86°F) [see USP Controlled Room Temperature]. TIROSINT capsules should be protected from heat, light and moisture.Do not separate the individual cavities containing the drug from the intact blister as important information may be lost (i.e., manufacturer/distributor names, distributor contact phone number, lot number, and expiration date), and do not remove the individual capsules from blister packaging until ready to use.Cefdinir for Oral Suspension, USP 125 mg/5 mL 60 MILLILITER in a BOTTLE/1 BOTTLE in a CARTON (53217-298-01)Repackaged byAidarex Pharmaceuticals, LLCCorona, CA 92880Cefdinir for Oral Suspension, USP 125 mg/5 mL 60 MILLILITER in a BOTTLE/1 BOTTLE in a CARTON (53217-298-01)Repackaged byAidarex Pharmaceuticals, LLCCorona, CA 92880Cefdinir for Oral Suspension, USP 125 mg/5 mL 60 MILLILITER in a BOTTLE/1 BOTTLE in a CARTON (53217-298-01)Repackaged byAidarex Pharmaceuticals, LLCCorona, CA 92880Cefdinir for Oral Suspension, USP 125 mg/5 mL 60 MILLILITER in a BOTTLE/1 BOTTLE in a CARTON (53217-298-01)Repackaged byAidarex Pharmaceuticals, LLCCorona, CA 92880Cefdinir for Oral Suspension, USP 125 mg/5 mL 60 MILLILITER in a BOTTLE/1 BOTTLE in a CARTON (53217-298-01)Repackaged byAidarex Pharmaceuticals, LLCCorona, CA 92880
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Thyroid hormones exert their physiologic actions through control of DNA transcription and protein synthesis. Triiodothyronine (T3) and L-thyroxine (T4) diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNA. This hormone nuclear receptor complex activates gene transcription and synthesis of messenger RNA and cytoplasmic proteins.
The physiological actions of thyroid hormones are produced predominantly by T3, the majority of which (approximately 80%) is derived from T4 by deiodination in peripheral tissues.
Non-Clinical Toxicology
TIROSINT is contraindicated in patients with uncorrected adrenal insufficiencyOvertreatment with levothyroxine may cause an increase in heart rate, cardiac wall thickness, and cardiac contractility and may precipitate angina or arrhythmias, particularly in patients with cardiovascular disease and in elderly patients. Initiate TIROSINT therapy in this population at lower doses than those recommended in younger individuals or in patients without cardiac disease
Monitor for cardiac arrhythmias during surgical procedures in patients with coronary artery disease receiving suppressive TIROSINT therapy. Monitor patients receiving concomitant TIROSINT and sympathomimetic agents for signs and symptoms of coronary insufficiencyIf cardiac symptoms develop or worsen, reduce the TIROSINT dose or withhold it for one week and restart at a lower dose.
Adverse reactions associated with TIROSINT therapy are primarily those of hyperthyroidism due to therapeutic overdosage They include the following:
Seizures have been reported rarely with the institution of levothyroxine therapy.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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