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Tramadol ER

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Overview

What is Tramadol ER?



What does Tramadol ER look like?



What are the available doses of Tramadol ER?

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What should I talk to my health care provider before I take Tramadol ER?

Sorry No records found

How should I use Tramadol ER?

PRECAUTIONS

Use in Renal and Hepatic Disease.

WARNINGS

Misuse, Abuse and Diversion of Opioids

DRUG ABUSE AND ADDICTION

exceeding 300 mg per day.

exceeding 300 mg per day.

WARNINGS


What interacts with Tramadol ER?

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What are the warnings of Tramadol ER?

Sorry No Records found


What are the precautions of Tramadol ER?

Sorry No Records found


What are the side effects of Tramadol ER?

Sorry No records found


What should I look out for while using Tramadol ER?

Seizure Risk

Seizures have been reported in patients receiving tramadol within the recommended dosage range. Spontaneous post-marketing reports indicate that seizure risk is increased with doses of tramadol above the recommended range. Concomitant use of tramadol increases the seizure risk in patients taking:

Administration of tramadol may enhance the seizure risk in patients taking

:

Risk of convulsions may also increase in patients with epilepsy, those with a history of seizures, or in patients with a recognized risk for seizure (such as head trauma, metabolic disorders, alcohol and drug withdrawal, CNS infections). In tramadol overdose, naloxone administration may increase the risk of seizure.

Suicide Risk

Serotonin Syndrome Risk

The development of a potentially life-threatening serotonin syndrome may occur with use of tramadol products, including tramadol hydrochloride ER tablets, particularly with concomitant use of serotonergic drugs such as SSRIs, SNRIs, TCAs, MAOIs and triptans, with drugs which impair metabolism of serotonin (including MAOIs) and with drugs which impair metabolism of tramadol (CYP2D6 and CYP3A4 inhibitors). This may occur within the recommended dose. (See CLINICAL PHARMACOLOGY—Pharmacokinetics).

Serotonin syndrome may include mental-status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination) and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea).

CONTRAINDICATIONS

WARNINGS

Seizure Risk

OVERDOSAGE

WARNINGS

­Respiratory Depression

WARNINGS

DRUG ABUSE AND ADDICTION


What might happen if I take too much Tramadol ER?


How should I store and handle Tramadol ER?

Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP/NF with a child-resistant closure.A Schedule CIII Narcotic.Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP/NF with a child-resistant closure.A Schedule CIII Narcotic.Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP/NF with a child-resistant closure.A Schedule CIII Narcotic.Par Pharmaceutical Companies, Inc.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

in vitro

Table 1

PRECAUTIONS

Drug Interactions

PRECAUTIONS

Use in Renal and Hepatic Disease

DOSAGE AND ADMINISTRATION

PRECAUTIONS

Use in Renal and Hepatic Disease

DOSAGE AND ADMINISTRATION

PRECAUTIONS

DOSAGE AND ADMINISTRATION

In vitro

PRECAUTIONS

Drug Interactions

PRECAUTIONS

Drug Interactions

Non-Clinical Toxicology
Seizure Risk

Seizures have been reported in patients receiving tramadol within the recommended dosage range. Spontaneous post-marketing reports indicate that seizure risk is increased with doses of tramadol above the recommended range. Concomitant use of tramadol increases the seizure risk in patients taking:

Administration of tramadol may enhance the seizure risk in patients taking

:

Risk of convulsions may also increase in patients with epilepsy, those with a history of seizures, or in patients with a recognized risk for seizure (such as head trauma, metabolic disorders, alcohol and drug withdrawal, CNS infections). In tramadol overdose, naloxone administration may increase the risk of seizure.

Suicide Risk

Serotonin Syndrome Risk

The development of a potentially life-threatening serotonin syndrome may occur with use of tramadol products, including tramadol hydrochloride ER tablets, particularly with concomitant use of serotonergic drugs such as SSRIs, SNRIs, TCAs, MAOIs and triptans, with drugs which impair metabolism of serotonin (including MAOIs) and with drugs which impair metabolism of tramadol (CYP2D6 and CYP3A4 inhibitors). This may occur within the recommended dose. (See CLINICAL PHARMACOLOGY—Pharmacokinetics).

Serotonin syndrome may include mental-status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination) and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea).

CONTRAINDICATIONS

WARNINGS

Seizure Risk

OVERDOSAGE

WARNINGS

­Respiratory Depression

WARNINGS

DRUG ABUSE AND ADDICTION

Few systemic data have been collected on the metabolism of bupropion following concomitant administration with other drugs or, alternatively, the effect of concomitant administration of bupropion on the metabolism of other drugs.

Because bupropion is extensively metabolized, the coadministration of other drugs may affect its clinical activity. studies indicate that bupropion is primarily metabolized to hydroxybupropion by the CYP2B6 isoenzyme. Therefore, the potential exists for a drug interaction between bupropion hydrochloride tablets and drugs that are substrates or inhibitors of the CYP2B6 isoenzyme (e.g., orphenadrine, thiotepa, and cyclophosphamide). In addition, studies suggest that paroxetine, sertraline, norfluoxetine, and fluvoxamine as well as nelfinavir, ritonavir, and efavirenz inhibit the hydroxylation of bupropion. No clinical studies have been performed to evaluate this finding. The threohydrobupropion metabolite of bupropion does not appear to be produced by the cytochrome P450 isoenzymes. The effects of concomitant administration of cimetidine on the pharmacokinetics of bupropion and its active metabolites were studied in 24 healthy young male volunteers. Following oral administration of two 150 mg sustained-release tablets with and without 800 mg of cimetidine, the pharmacokinetics of bupropion and hydroxybupropion were unaffected. However, there were 16% and 32% increases in the AUC and C, respectively, of the combined moieties of threohydrobupropion and erythrohydrobupropion.

While not systematically studied, certain drugs may induce the metabolism of bupropion (e.g., carbamazepine, phenobarbital, phenytoin).

Multiple oral doses of bupropion had no statistically significant effects on the single dose pharmacokinetics of lamotrigine in 12 healthy volunteers.

Animal data indicated that bupropion may be an inducer of drug-metabolizing enzymes in humans. In one study, following chronic administration of bupropion, 100 mg 3 times daily to 8 healthy male volunteers for 14 days, there was no evidence of induction of its own metabolism. Nevertheless, there may be the potential for clinically important alterations of blood levels of coadministered drugs.

CLINICAL PHARMACOLOGY

DOSAGE AND ADMINISTRATION

CLINICAL PHARMACOLOGY

DOSAGE AND ADMINISTRATION

CLINICAL PHARMACOLOGY — Pharmacokinetics

WARNINGS – Serotonin Syndrome

WARNINGS - Serotonin Syndrome

carbamazepine

quinidine

CLINICAL PHARMACOLOGY

Drug Interactions

In vitro

In vitro

In vitro

Salmonella

E. coli

DRUG ABUSE AND ADDICTION

CLINICAL PHARMACOLOGY

DOSAGE AND ADMINISTRATION

Table 2

Table 2

Adverse events with incidence rates of 1.0% to less than 5.0%

Eye disorders:

Gastrointestinal disorders:

General disorders:

Infections and infestations:

Investigations:

Metabolism and nutrition disorders:

Musculoskeletal, connective tissue and bone disorders:

Nervous system disorders:

Psychiatric disorders:

Respiratory, thoracic and mediastinal disorders:

Skin and subcutaneous tissue disorders:

Vascular disorders:

Adverse events with incidence rates of 0.5% to less than 1.0% and serious adverse events reported in at least 2 patients.

Cardiac disorders:

Ear and labyrinth disorders:

Gastrointestinal disorders:

General disorders:

Hepato-biliary disorders:

Infections and infestations:

Injury and poisoning:

Investigations:

Musculoskeletal, connective tissue and bone disorders:

Nervous system disorders:

Psychiatric disorders:

Renal and urinary disorders:

Respiratory, thoracic and mediastinal disorders:

Skin and subcutaneous tissue disorders:

Vascular disorders:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).