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Scopalamine

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Overview

What is Transderm Scop?

The Transderm Scōp (scopolamine) transdermal system is a circular flat patch designed for continuous release of scopolamine following application to an area of intact skin on the head, behind the ear. Each system contains 1.5 mg of scopolamine base. Scopolamine is α -(hydroxymethyl) benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo [3.3.1.0] non-7-yl ester. The empirical formula is CHNO and its structural formula is:

Scopolamine is a viscous liquid that has a molecular weight of 303.35 and a pKa of 7.55-7.81. The Transderm Scōp® system is a film 0.2 mm thick and 2.5 cm, with four layers. Proceeding from the visible surface towards the surface attached to the skin, these layers are: (1) a backing layer of tan-colored, aluminized, polyester film; (2) a drug reservoir of scopolamine, light mineral oil, and polyisobutylene; (3) a microporous polypropylene membrane that controls the rate of delivery of scopolamine from the system to the skin surface; and (4) an adhesive formulation of mineral oil, polyisobutylene, and scopolamine. A protective peel strip of siliconized polyester, which covers the adhesive layer, is removed before the system is used. The inactive components, light mineral oil (12.4 mg) and polyisobutylene (11.4 mg), are not released from the system.

Cross section of the system:



What does Transderm Scop look like?



What are the available doses of Transderm Scop?

Continuous release, circular, flat, tan colored patch ()

What should I talk to my health care provider before I take Transderm Scop?

How should I use Transderm Scop?

Transderm Scōp is indicated in adults for prevention of nausea and vomiting associated with motion sickness.

Each Transderm Scōp patch is formulated to deliverapproximately 1mg of scopolamine over 3 days. Only one patch should be worn at any time. .The patch should be applied only to the skin in the postauricular (hairless area behind one ear) area.

Handling


What interacts with Transderm Scop?

Sorry No Records found


What are the warnings of Transderm Scop?

Sorry No Records found


What are the precautions of Transderm Scop?

Sorry No Records found


What are the side effects of Transderm Scop?

Sorry No records found


What should I look out for while using Transderm Scop?

Transderm Scōp is contraindicated in the following populations:


What might happen if I take too much Transderm Scop?

Because strategies for the management of drug overdose continually evolve, it is strongly recommended that a poison control center be contacted to obtain up-to-date information regarding the management of Transderm Scōp patch overdose. The prescriber should be mindful that antidotes used routinely in the past may no longer be considered optimal treatment. For example, physostigmine, used more or less routinely in the past, is seldom recommended for the routine management of anticholinergic syndromes.Until up-to-date authoritative advice is obtained, routine supportive measures should be directed to maintaining adequate respiratory and cardiac function.The signs and symptoms of anticholinergic toxicity include: lethargy, somnolence, coma, confusion, agitation, hallucinations, convulsion, visual disturbance, dry flushed skin, dry mouth, decreased bowel sounds, urinary retention, tachycardia, hypertension, and supraventricular arrhythmias. These symptoms can be severe and may require medical intervention.In cases of toxicity remove the patch. Serious symptomatic cases of overdosage involving multiple patch applications and/or ingestion may be managed by initially ensuring the patient has an adequate airway, and supporting respiration and circulation. This should be rapidly followed by removal of all patches from the skin and the mouth. If there is evidence of patch ingestion, gastric lavage, endoscopic removal of swallowed patches, or administration of activated charcoal should be considered, as indicated by the clinical situation. In any case where there is serious overdosage or signs of evolving acute toxicity, continuous monitoring of vital signs and ECG, establishment of intravenous access, and administration of oxygen are all recommended.The symptoms of overdose/toxicity due to scopolamine should be carefully distinguished from the occasionally observed syndrome of withdrawal. Although mental confusion and dizziness may be observed with both acute toxicity and withdrawal, other characteristic findings differ: tachyarrhythmias, dry skin, and decreased bowel sounds suggest anticholinergic toxicity, while bradycardia, headache, nausea and abdominal cramps, and sweating suggest post-removal withdrawal. Obtaining a careful history is crucial to making the correct diagnosis.


How should I store and handle Transderm Scop?

The Transderm Scōp system is a tan-colored circular patch with an , 2.5 cm, on a clear, oversized, hexagonal peel strip, which is removed prior to use.Each Transderm Scōp system contains 1.5 mg of scopolamine and is formulated to deliver approximately 1 mg of scopolamine over 3 days. Transderm Scōp is available in packages of 10 patches and 24 patches. Each patch is foil wrapped. Patient instructions are included. StorageHandlingThe Transderm Scōp system is a tan-colored circular patch with an , 2.5 cm, on a clear, oversized, hexagonal peel strip, which is removed prior to use.Each Transderm Scōp system contains 1.5 mg of scopolamine and is formulated to deliver approximately 1 mg of scopolamine over 3 days. Transderm Scōp is available in packages of 10 patches and 24 patches. Each patch is foil wrapped. Patient instructions are included. StorageHandlingThe Transderm Scōp system is a tan-colored circular patch with an , 2.5 cm, on a clear, oversized, hexagonal peel strip, which is removed prior to use.Each Transderm Scōp system contains 1.5 mg of scopolamine and is formulated to deliver approximately 1 mg of scopolamine over 3 days. Transderm Scōp is available in packages of 10 patches and 24 patches. Each patch is foil wrapped. Patient instructions are included. StorageHandlingThe Transderm Scōp system is a tan-colored circular patch with an , 2.5 cm, on a clear, oversized, hexagonal peel strip, which is removed prior to use.Each Transderm Scōp system contains 1.5 mg of scopolamine and is formulated to deliver approximately 1 mg of scopolamine over 3 days. Transderm Scōp is available in packages of 10 patches and 24 patches. Each patch is foil wrapped. Patient instructions are included. StorageHandling


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Scopolamine, a belladonna alkaloid, is an anticholinergic agent. Scopolamine acts: i) as a competitive inhibitor at postganglionic muscarinic receptor sites of the parasympathetic nervous system, and ii) on smooth muscles that respond to acetylcholine but lack cholinergic innervation. It has been suggested that scopolamine acts in the central nervous system (CNS) by blocking cholinergic transmission from the vestibular nuclei to higher centers in the CNS and from the reticular formation to the vomiting center. Scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, cause drowsiness, dilate the pupils, increase heart rate, and depress motor function.

Non-Clinical Toxicology
Transderm Scōp is contraindicated in the following populations:

Patients currently being treated for Open Angle Glaucoma

Patients should be advised to remove the patch immediately and promptly contact a physician in the event that they experience symptoms of acute angle closure glaucoma (pain and reddening of the eyes, accompanied by dilated pupils).

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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