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travoprost

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Overview

What is Travoprost Ophthalmic Solution 0.004%?

Travoprost is a clear, colorless to slightly yellow oil that is very soluble in acetonitrile, methanol, octanol, and chloroform. It is practically insoluble in water.

Travoprost Ophthalmic Solution 0.004% is supplied as sterile, buffered aqueous solution of travoprost with a pH of approximately 6.0 and an osmolality of approximately 290 mOsmol/kg.

Travoprost ophthalmic solution contains: travoprost 0.04 mg/mL; benzalkonium chloride 0.15 mg/mL; boric acid, edetate disodium, mannitol, polyoxyl 40 hydrogenated castor oil, tromethamine, sodium hydroxide and/or hydrochloric acid (to adjust pH) and water for injection.



What does Travoprost Ophthalmic Solution 0.004% look like?



What are the available doses of Travoprost Ophthalmic Solution 0.004%?

Solution containing 0.04 mg/mL travoprost ophthalmic solution. ( )

What should I talk to my health care provider before I take Travoprost Ophthalmic Solution 0.004%?

Use in pediatric patients below the age of 16 years is not recommended because of potential safety concerns related to increased pigmentation following long-term chronic use. ( )

How should I use Travoprost Ophthalmic Solution 0.004%?

Travoprost Ophthalmic Solution USP, 0.004% is indicated for the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension.

The recommended dosage is one drop in the affected eye(s) once daily in the evening. Travoprost Ophthalmic Solution USP, 0.004% should not be administered more than once daily since it has been shown that more frequent administration of prostaglandin analogs may decrease the intraocular pressure lowering effect.

Reduction of the intraocular pressure starts approximately 2 hours after the first administration with maximum effect reached after 12 hours.

Travoprost ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. If more than one topical ophthalmic drug is being used, the drugs should be administered at least five (5) minutes apart.


What interacts with Travoprost Ophthalmic Solution 0.004%?

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What are the warnings of Travoprost Ophthalmic Solution 0.004%?

Sorry No Records found


What are the precautions of Travoprost Ophthalmic Solution 0.004%?

Sorry No Records found


What are the side effects of Travoprost Ophthalmic Solution 0.004%?

Sorry No records found


What should I look out for while using Travoprost Ophthalmic Solution 0.004%?

None


What might happen if I take too much Travoprost Ophthalmic Solution 0.004%?

Sorry No Records found


How should I store and handle Travoprost Ophthalmic Solution 0.004%?

Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F). [See USP Controlled Room Temperature.] Do not freeze.Protect from light.Discard unused portion. Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F). [See USP Controlled Room Temperature.] Do not freeze.Protect from light.Discard unused portion. Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F). [See USP Controlled Room Temperature.] Do not freeze.Protect from light.Discard unused portion. Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F). [See USP Controlled Room Temperature.] Do not freeze.Protect from light.Discard unused portion. Travoprost Ophthalmic Solution 0.004% is a sterile, isotonic, buffered, preserved, aqueous solution of travoprost (0.04 mg/mL)Travoprost ophthalmic solution is supplied as a 2.5 mL and a 5 mL solution, each in a 5 mL natural translucent polypropylene dispenser bottle with a natural translucent low density polyethylene dropper tip and a turquoise polyethylene overcap with a tamper evident locking ring.2.5 mL fill NDC 49884-044-485 mL fill NDC 49884-044-63StorageStore at 2º to 25ºC (36º to 77ºF).Travoprost Ophthalmic Solution 0.004% is a sterile, isotonic, buffered, preserved, aqueous solution of travoprost (0.04 mg/mL)Travoprost ophthalmic solution is supplied as a 2.5 mL and a 5 mL solution, each in a 5 mL natural translucent polypropylene dispenser bottle with a natural translucent low density polyethylene dropper tip and a turquoise polyethylene overcap with a tamper evident locking ring.2.5 mL fill NDC 49884-044-485 mL fill NDC 49884-044-63StorageStore at 2º to 25ºC (36º to 77ºF).Travoprost Ophthalmic Solution 0.004% is a sterile, isotonic, buffered, preserved, aqueous solution of travoprost (0.04 mg/mL)Travoprost ophthalmic solution is supplied as a 2.5 mL and a 5 mL solution, each in a 5 mL natural translucent polypropylene dispenser bottle with a natural translucent low density polyethylene dropper tip and a turquoise polyethylene overcap with a tamper evident locking ring.2.5 mL fill NDC 49884-044-485 mL fill NDC 49884-044-63StorageStore at 2º to 25ºC (36º to 77ºF).Travoprost Ophthalmic Solution 0.004% is a sterile, isotonic, buffered, preserved, aqueous solution of travoprost (0.04 mg/mL)Travoprost ophthalmic solution is supplied as a 2.5 mL and a 5 mL solution, each in a 5 mL natural translucent polypropylene dispenser bottle with a natural translucent low density polyethylene dropper tip and a turquoise polyethylene overcap with a tamper evident locking ring.2.5 mL fill NDC 49884-044-485 mL fill NDC 49884-044-63StorageStore at 2º to 25ºC (36º to 77ºF).Travoprost Ophthalmic Solution 0.004% is a sterile, isotonic, buffered, preserved, aqueous solution of travoprost (0.04 mg/mL)Travoprost ophthalmic solution is supplied as a 2.5 mL and a 5 mL solution, each in a 5 mL natural translucent polypropylene dispenser bottle with a natural translucent low density polyethylene dropper tip and a turquoise polyethylene overcap with a tamper evident locking ring.2.5 mL fill NDC 49884-044-485 mL fill NDC 49884-044-63StorageStore at 2º to 25ºC (36º to 77ºF).Travoprost Ophthalmic Solution 0.004% is a sterile, isotonic, buffered, preserved, aqueous solution of travoprost (0.04 mg/mL)Travoprost ophthalmic solution is supplied as a 2.5 mL and a 5 mL solution, each in a 5 mL natural translucent polypropylene dispenser bottle with a natural translucent low density polyethylene dropper tip and a turquoise polyethylene overcap with a tamper evident locking ring.2.5 mL fill NDC 49884-044-485 mL fill NDC 49884-044-63StorageStore at 2º to 25ºC (36º to 77ºF).


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Non-Clinical Toxicology
None

Results of preliminary studies in humans and rats suggest that nonabsorbable antacids given concurrently with lactulose may inhibit the desired lactulose-induced drop in colonic pH. Therefore, a possible lack of desired effect of treatment should be taken into consideration before such drugs are given concomitantly with lactulose solution.

Travoprost ophthalmic solution has been reported to cause changes to pigmented tissues. The most frequently reported changes have been increased pigmentation of the iris, periorbital tissue (eyelid) and eyelashes. Pigmentation is expected to increase as long as travoprost is administered. The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytes. After discontinuation of travoprost, pigmentation of the iris is likely to be permanent, while pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patients. Patients who receive treatment should be informed of the possibility of increased pigmentation. The long term effects of increased pigmentation are not known.

Iris color change may not be noticeable for several months to years. Typically, the brown pigmentation around the pupil spreads concentrically towards the periphery of the iris and the entire iris or parts of the iris become more brownish. Neither nevi nor freckles of the iris appear to be affected by treatment. While treatment with travoprost ophthalmic solution can be continued in patients who develop noticeably increased iris pigmentation, these patients should be examined regularly. (see , ).

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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