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Tresiba
Overview
What is Tresiba?
TRESIBA (insulin degludec injection) is a long-acting basal human insulin analog for subcutaneous injection. Insulin degludec is produced by a process that includes expression of recombinant DNA in followed by chemical modification.
Insulin degludec differs from human insulin in that the amino acid threonine in position B30 has been omitted and a side-chain consisting of glutamic acid and a C16 fatty acid has been attached (chemical name: LysB29(Nε-hexadecandioyl-γ-Glu) des(B30) human insulin). Insulin degludec has a molecular formula of CHNOS and a molecular weight of 6103.97. It has the following structure:
TRESIBA is a sterile, aqueous, clear, and colorless solution that contains insulin degludec 100 units/mL (U-100) or 200 units/mL (U-200).
Inactive ingredients for the 100 units/mL are glycerol 19.6 mg/mL, phenol 1.50 mg/mL, metacresol 1.72 mg/mL, zinc 32.7 mcg/mL and water for injection.
Inactive ingredients for the 200 units/mL are glycerol 19.6 mg/mL, phenol 1.50 mg/mL, metacresol 1.72 mg/mL, zinc 71.9 mcg/mL and water for injection.
TRESIBA has a pH of approximately 7.6. Hydrochloric acid or sodium hydroxide may be added to adjust pH.
What does Tresiba look like?
What are the available doses of Tresiba?
TRESIBA injection is available in the following package sizes:
What should I talk to my health care provider before I take Tresiba?
How should I use Tresiba?
TRESIBA is indicated to improve glycemic control in patients 1 year of age and older with diabetes mellitus.
Limitations of Use
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2.1
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2.1
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2.2
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2.2
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2.2
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2.2
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What interacts with Tresiba?
Sorry No Records found
What are the warnings of Tresiba?
Sorry No Records found
What are the precautions of Tresiba?
Sorry No Records found
What are the side effects of Tresiba?
Sorry No records found
What should I look out for while using Tresiba?
TRESIBA is contraindicated:
What might happen if I take too much Tresiba?
An excess of insulin relative to food intake, energy expenditure, or both may lead to severe and sometimes prolonged and life-threatening hypoglycemia and hypokalemia . Mild episodes of hypoglycemia usually can be treated with oral glucose. Adjustments in drug dosage, meal patterns, or exercise may be needed. More severe episodes of hypoglycemia with coma, seizure, or neurologic impairment may be treated with intramuscular/subcutaneous glucagon or concentrated intravenous glucose. After apparent clinical recovery from hypoglycemia, continued observation and additional carbohydrate intake may be necessary to avoid reoccurrence of hypoglycemia. Hypokalemia must be corrected appropriately.
How should I store and handle Tresiba?
Storage and HandlingThe lyophilized vials should be stored refrigerated at 2° to 8°C (36° to 46°F).Storage and HandlingThe lyophilized vials should be stored refrigerated at 2° to 8°C (36° to 46°F).Metformin Hydrochloride Tablets USP 1000 mg, are available as white to off-white film-coated oval-shaped tablets, scored on two sides, debossed with “9” on the left side of the score and “3” on the right side of the score on one side and “72” on the left side of the score and “14” on the right side of the score on the other side. They are available in bottles of 30, 60, 90, 120, 180 and 270.
