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tretinoin, avobenzone, octinoxate, octisalate and titanium dioxide

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Overview

What is Tretinopak?

Tretinoin Cream, a topical retinoid, contains tretinoin 0.025% by weight in a hydrophilic cream vehicle of stearic acid, polyolprepolymer-2, isopropyl myristate, polyoxyl 40 stearate, propylene glycol, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water. Chemically, tretinoin is all-retinoic acid (CH0; molecular weight 300.44 vitamin A acid) and has the following structural formula:



What does Tretinopak look like?



What are the available doses of Tretinopak?

Sorry No records found.

What should I talk to my health care provider before I take Tretinopak?

Sorry No records found

How should I use Tretinopak?

■ Helps prevent sunburn.■ If used as directed with other sun protection measures (see Directions), decreases the risk of cancer and early skin aging caused by the sun.

■ Apply liberally 15 minutes before sun exposure ■ Use a water-resistant sunscreen if swimming or sweating or immediately after towel drying■ Reaply: ■ at least every 2 hours. ■ Sun Protection Measures. Spending time in the sun increases your risk of skin cancer and early skin aging. To decrease the risk, regularly use a sunscreen with a broad spectrum SPF of 15 or higher and other sun protection measures including: ■ Limit time in the sun, especially from 10 a.m. - 2 p.m. ■ Wear long-sleeve shirts, pants, hats, and sunglasses. ■ Children under six months of age: Ask a doctor.


What interacts with Tretinopak?

Sorry No Records found


What are the warnings of Tretinopak?

Sorry No Records found


What are the precautions of Tretinopak?

Sorry No Records found


What are the side effects of Tretinopak?

Sorry No records found


What should I look out for while using Tretinopak?

The product should not be used if there is hypersensitivity to any of the ingredients.

For external use only


What might happen if I take too much Tretinopak?

If medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling, or discomfort may occur. Oral ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of vitamin A.


How should I store and handle Tretinopak?

Store bottles at controlled room temperature, 59° to 86°F (15° to 30°C) and dispense in tight, light-resistant containers (USP).Tretinoin Cream 0.025% is supplied in 20 g (NDC 0472-0117-20) and 45 g (NDC 0472-0117-45) tubes.Storage Conditions: Keep this and all medications out of the reach of children.Manufactured by:G&W NC Laboratories, LLC1877 Kawai RoadLincolnton, NC 28092 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USAFORM NO. 0117Rev. 10/14VC4494Tretinoin Cream 0.025% is supplied in 20 g (NDC 0472-0117-20) and 45 g (NDC 0472-0117-45) tubes.Storage Conditions: Keep this and all medications out of the reach of children.Manufactured by:G&W NC Laboratories, LLC1877 Kawai RoadLincolnton, NC 28092 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USAFORM NO. 0117Rev. 10/14VC4494Tretinoin Cream 0.025% is supplied in 20 g (NDC 0472-0117-20) and 45 g (NDC 0472-0117-45) tubes.Storage Conditions: Keep this and all medications out of the reach of children.Manufactured by:G&W NC Laboratories, LLC1877 Kawai RoadLincolnton, NC 28092 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USAFORM NO. 0117Rev. 10/14VC4494Tretinoin Cream 0.025% is supplied in 20 g (NDC 0472-0117-20) and 45 g (NDC 0472-0117-45) tubes.Storage Conditions: Keep this and all medications out of the reach of children.Manufactured by:G&W NC Laboratories, LLC1877 Kawai RoadLincolnton, NC 28092 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USAFORM NO. 0117Rev. 10/14VC4494Tretinoin Cream 0.025% is supplied in 20 g (NDC 0472-0117-20) and 45 g (NDC 0472-0117-45) tubes.Storage Conditions: Keep this and all medications out of the reach of children.Manufactured by:G&W NC Laboratories, LLC1877 Kawai RoadLincolnton, NC 28092 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USAFORM NO. 0117Rev. 10/14VC4494Tretinoin Cream 0.025% is supplied in 20 g (NDC 0472-0117-20) and 45 g (NDC 0472-0117-45) tubes.Storage Conditions: Keep this and all medications out of the reach of children.Manufactured by:G&W NC Laboratories, LLC1877 Kawai RoadLincolnton, NC 28092 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USAFORM NO. 0117Rev. 10/14VC4494Tretinoin Cream 0.025% is supplied in 20 g (NDC 0472-0117-20) and 45 g (NDC 0472-0117-45) tubes.Storage Conditions: Keep this and all medications out of the reach of children.Manufactured by:G&W NC Laboratories, LLC1877 Kawai RoadLincolnton, NC 28092 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USAFORM NO. 0117Rev. 10/14VC4494Tretinoin Cream 0.025% is supplied in 20 g (NDC 0472-0117-20) and 45 g (NDC 0472-0117-45) tubes.Storage Conditions: Keep this and all medications out of the reach of children.Manufactured by:G&W NC Laboratories, LLC1877 Kawai RoadLincolnton, NC 28092 USADistributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USAFORM NO. 0117Rev. 10/14VC4494


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Although the exact mode of action of tretinoin is unknown, current evidence suggests that topical tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing extrusion of the comedones.

Non-Clinical Toxicology
The product should not be used if there is hypersensitivity to any of the ingredients.

For external use only

Concomitant topical medication, medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices or lime should be used with caution because of possible interaction with tretinoin. Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid with tretinoin cream. It also is advisable to “rest” a patient’s skin until the effects of such preparations subside before use of tretinoin cream is begun.

If a reaction suggesting sensitivity or chemical irritation occurs, use of the medication should be discontinued. Exposure to sunlight, including sunlamps, should be minimized during the use of tretinoin cream, and patients with sunburn should be advised not to use the product until fully recovered because of heightened susceptibility to sunlight as a result of the use of tretinoin. Patients who may be required to have considerable sun exposure due to occupation and those with inherent sensitivity to the sun should exercise particular caution. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Weather extremes, such as wind or cold, also may be irritating to patients under treatment with tretinoin.

Tretinoin cream, 0.025% should be kept away from the eyes, the mouth, the paranasal creases, and mucous membranes. Topical use may induce severe local erythema and peeling at the site of application. If the degree of local irritation warrants, patients should be directed to temporarily use the medication less frequently, discontinue use temporarily, or discontinue use altogether.  Efficacy at reduced frequencies of application has not been established. Tretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition.

The skin of certain sensitive individuals may become excessively red, edematous, blistered, or crusted. If these effects occur, the medication should either be discontinued until the integrity of the skin is restored, or the medication dosing frequency should be adjusted temporarily to a level the patient can tolerate.  However, efficacy has not been established for lower dosing frequencies. True contact allergy to topical tretinoin is rarely encountered. Temporary hyper- or hypopigmentation has been reported with repeated application of tretinoin cream. Some individuals have been reported to have heightened susceptibility to sunlight while under treatment with tretinoin cream. Adverse effects of tretinoin cream have been reversible upon discontinuation of therapy (see section).

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).