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Norgestimate and Ethinyl Estradiol

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Overview

What is Tri-Linyah?

Tri-Linyah is a combination oral contraceptive containing the progestational compound norgestimate and the estrogenic compound ethinyl estradiol. Norgestimate is designated as (18,19-Dinor-17-pregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-, oxime,(17  )-(+)-) and ethinyl estradiol is designated as (19-nor-17  -pregna,1,3,5(10)-trien-20-yne-3,17-diol).



What does Tri-Linyah look like?



What are the available doses of Tri-Linyah?

Tri-Linyah Tablets are available in blister cards. Each blister card contains 28 tablets in the following order:

What should I talk to my health care provider before I take Tri-Linyah?

Nursing mothers: Not recommended; can decrease milk production. ()

How should I use Tri-Linyah?

Tri-Linyah Tablets are indicated for use by females of reproductive potential to prevent pregnancy .

Tri-Linyah is dispensed in 28-tablet blister Tri-Linyah may be started using either a Day 1 start or a Sunday start (see Table 1). The plastic compact is pre-set for a Sunday start. Day 1 Start day-label stickers are available. For the first cycle of a Sunday Start regimen, an additional method of contraception should be used until after the first 7 consecutive days of administration.


What interacts with Tri-Linyah?

Sorry No Records found


What are the warnings of Tri-Linyah?

Sorry No Records found


What are the precautions of Tri-Linyah?

Sorry No Records found


What are the side effects of Tri-Linyah?

Sorry No records found


What should I look out for while using Tri-Linyah?

A high risk of arterial or venous thrombotic diseases ()

Liver tumors or liver disease ()

Undiagnosed abnormal uterine bleeding ()

Pregnancy ()

Breast cancer or other estrogen- or progestin-sensitive cancer ()

Co-administration with Hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir ()


What might happen if I take too much Tri-Linyah?

There have been no reports of serious ill effects from overdosage of oral contraceptives, including ingestion by children. Overdosage may cause withdrawal bleeding in females and nausea.


How should I store and handle Tri-Linyah?

Storage and HandlingStore at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (59°F and 86°F). Store blister pack in original carton to protect from light. FARYDAK capsules should not be opened, crushed, or chewed. Direct contact of the powder in FARYDAK capsules with the skin or mucous membranes should be avoided. If such contact occurs wash thoroughly. Personnel should avoid exposure to crushed and/or broken capsules.FARYDAK is a cytotoxic drug. Follow special handling and disposal procedures .Storage and HandlingStore at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (59°F and 86°F). Store blister pack in original carton to protect from light. FARYDAK capsules should not be opened, crushed, or chewed. Direct contact of the powder in FARYDAK capsules with the skin or mucous membranes should be avoided. If such contact occurs wash thoroughly. Personnel should avoid exposure to crushed and/or broken capsules.FARYDAK is a cytotoxic drug. Follow special handling and disposal procedures .Storage and HandlingStore at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (59°F and 86°F). Store blister pack in original carton to protect from light. FARYDAK capsules should not be opened, crushed, or chewed. Direct contact of the powder in FARYDAK capsules with the skin or mucous membranes should be avoided. If such contact occurs wash thoroughly. Personnel should avoid exposure to crushed and/or broken capsules.FARYDAK is a cytotoxic drug. Follow special handling and disposal procedures .Product: 53002-1198NDC: 53002-1198-1 1 TABLET in a BLISTER PACK NDC: 53002-1198-2 1 TABLET in a BLISTER PACK Product: 53002-1198NDC: 53002-1198-1 1 TABLET in a BLISTER PACK NDC: 53002-1198-2 1 TABLET in a BLISTER PACK Product: 53002-1198NDC: 53002-1198-1 1 TABLET in a BLISTER PACK NDC: 53002-1198-2 1 TABLET in a BLISTER PACK


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

        

COCs lower the risk of becoming pregnant primarily by suppressing ovulation. Other possible mechanisms may include cervical mucus changes that inhibit sperm penetration and endometrial changes that reduce the likelihood of implantation.

        

Acne is a skin condition with a multifactorial etiology, including androgen stimulation of sebum production. While the combination of ethinyl estradiol and norgestimate increases sex hormone-binding globulin (SHBG) and decreases free testosterone, the relationship between these changes and a decrease in the severity of facial acne in otherwise healthy women with this skin condition has not been established.

Non-Clinical Toxicology
A high risk of arterial or venous thrombotic diseases ()

Liver tumors or liver disease ()

Undiagnosed abnormal uterine bleeding ()

Pregnancy ()

Breast cancer or other estrogen- or progestin-sensitive cancer ()

Co-administration with Hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir ()

(See and .) Fluconazole is a potent inhibitor of cytochrome P450 (CYP) isoenzyme 2C9 and 2C19, and a moderate inhibitor of CYP3A4. In addition to the observed / documented interactions mentioned below, there is a risk of increased plasma concentration of other compounds metabolized by CYP2C9, CYP2C19 and CYP3A4 coadministered with fluconazole. Therefore, caution should be exercised when using these combinations and the patients should be carefully monitored. The enzyme inhibiting effect of fluconazole persists 4 to 5 days after discontinuation of fluconazole treatment due to the long half-life of fluconazole. Clinically or potentially significant drug interactions between fluconazole and the following agents/classes have been observed. These are described in greater detail below:

Thromboembolic Disorders and Other Vascular Problems:

Liver disease:

High blood pressure:

Carbohydrate and lipid metabolic effects:

Headache:

Bleeding Irregularities and Amenorrhea:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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