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Triklo

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Overview

What is Triklo?

TRIKLO CAPSULES, a lipid-regulating agent, are supplied as a liquid-filled gel capsule for oral administration. Each 1 gram capsule of TRIKLO CAPSULES contains at least 900 mg of the ethyl esters of omega-3 fatty acids sourced from fish oils. These are predominantly a combination of ethyl esters of eicosapentaenoic acid (EPA - approximately 465 mg) and docosahexaenoic acid (DHA - approximately 375 mg).

The empirical formula of EPA ethyl ester is CHO, and the molecular weight of EPA ethyl ester is 330.51. The structural formula of EPA ethyl ester is:

The empirical formula of DHA ethyl ester is CHO, and the molecular weight of DHA ethyl ester is 356.55. The structural formula of DHA ethyl ester is:

TRIKLO CAPSULES also contain the following inactive ingredients: alpha-tocopherol, gelatin, glycerin and purified water (components of the capsule shell).



What does Triklo look like?



What are the available doses of Triklo?

1 gram transparent soft-gelatin capsules. ()

What should I talk to my health care provider before I take Triklo?

How should I use Triklo?

TRIKLO CAPSULES are indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia (HTG).

The daily dose of TRIKLO CAPSULES is 4 grams per day. The daily dose may be taken as a single 4-gram dose (4 capsules) or as two 2-gram doses (2 capsules given twice daily).

Patients should be advised to swallow TRIKLO CAPSULES whole. Do not break open, crush, dissolve, or chew TRIKLO CAPSULES.


What interacts with Triklo?

Sorry No Records found


What are the warnings of Triklo?

Sorry No Records found


What are the precautions of Triklo?

Sorry No Records found


What are the side effects of Triklo?

Sorry No records found


What should I look out for while using Triklo?

TRIKLO CAPSULES are contraindicated in patients with known hypersensitivity (e.g., anaphylactic reaction) to TRIKLO CAPSULES or any of its components.


What might happen if I take too much Triklo?

Sorry No Records found


How should I store and handle Triklo?

Store the vials in original cartons between 20° to 25°C (68° to 77°F). [See .] Retain in the original package to protect from light.TRIKLO CAPSULES (omega-3-acid ethylesters capsules, USP) are supplied as 1 gram, transparent, soft-gelatin capsules filled with light-yellow oil and imprinted with "AN34".They are available as follows:Bottles of 60 capsules: NDC 70868-150-60Bottles of 120 capsules: NDC 70868-150-12TRIKLO CAPSULES (omega-3-acid ethylesters capsules, USP) are supplied as 1 gram, transparent, soft-gelatin capsules filled with light-yellow oil and imprinted with "AN34".They are available as follows:Bottles of 60 capsules: NDC 70868-150-60Bottles of 120 capsules: NDC 70868-150-12TRIKLO CAPSULES (omega-3-acid ethylesters capsules, USP) are supplied as 1 gram, transparent, soft-gelatin capsules filled with light-yellow oil and imprinted with "AN34".They are available as follows:Bottles of 60 capsules: NDC 70868-150-60Bottles of 120 capsules: NDC 70868-150-12


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

The mechanism of action of TRIKLO CAPSULES is not completely understood. Potential mechanisms of action include inhibition of acyl-CoA:1,2-diacylglycerol acyltransferase, increased mitochondrial and peroxisomal β-oxidation in the liver, decreased lipogenesis in the liver, and increased plasma lipoprotein lipase activity. TRIKLO CAPSULES may reduce the synthesis of triglycerides in the liver because EPA and DHA are poor substrates for the enzymes responsible for TG synthesis, and EPA and DHA inhibit esterification of other fatty acids.

Non-Clinical Toxicology
TRIKLO CAPSULES are contraindicated in patients with known hypersensitivity (e.g., anaphylactic reaction) to TRIKLO CAPSULES or any of its components.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving Tetracycline HCl Capsules, USP in conjunction with penicillin or other bactericidal antibiotics.

Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

The concurrent use of Tetracycline HCl Capsules, USP and methoxyflurane has been reported to result in fatal renal toxicity.

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and preparations containing iron, zinc, or sodium bicarbonate.

Concurrent use of Tetracycline HCl Capsules, USP may render oral contraceptives less effective.

In patients with hepatic impairment, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels should be monitored periodically during therapy with TRIKLO CAPSULES. In some patients, increases in ALT levels without a concurrent increase in AST levels were observed.

In some patients, TRIKLO CAPSULES increase LDL-C levels. LDL-C levels should be monitored periodically during therapy with TRIKLO CAPSULES.

Laboratory studies should be performed periodically to measure the patient's TG levels during therapy with TRIKLO CAPSULES.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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