Disclaimer:
Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.
Urecholine
Overview
What is Urecholine?
Bethanechol chloride, USP, a cholinergic agent, is a synthetic ester which is structurally and pharmacologically related to acetylcholine.
It is designated chemically as 2-[(aminocarbonyl)oxy]-, , -trimethyl-1-propanaminium chloride. Its structural formula is:
CHCIN0 M.W. 196.68
It is a white, hygroscopic crystalline powder having a slight amine-like odor, freely soluble in water.
Each tablet for oral administration contains 5 mg, 10 mg, 25 mg or 50 mg bethanechol chloride, USP. Tablets also contain the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose and sodium starch glycolate. The 25 mg and 50 mg tablets also contain D&C Yellow #10 aluminum lake and FD&C Yellow #6 aluminum lake.
What does Urecholine look like?





What are the available doses of Urecholine?
Sorry No records found.
What should I talk to my health care provider before I take Urecholine?
Sorry No records found
How should I use Urecholine?
Bethanechol Chloride Tablets USP are indicated for the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention.
Dosage must be individualized, depending on the type and severity of the condition to be treated.
Preferably give the drug when the stomach is empty. If taken soon after eating, nausea and vomiting may occur.
The usual adult oral dose ranges from 10 to 50 mg three or four times a day. The minimum effective dose is determined by giving 5 to 10 mg initially and repeating the same amount at hourly intervals until satisfactory response occurs, or until a maximum of 50 mg has been given. The effects of the drug sometimes appear within 30 minutes and are usually maximal within 60 to 90 minutes. The drug effects persist for about one hour.
If necessary, the effects of the drug can be abolished promptly by atropine (see).
What interacts with Urecholine?
Hypersensitivity to bethanechol chloride, hyperthyroidism, peptic ulcer, latent or active bronchial asthma, pronounced bradycardia or hypotension, vasomotor instability, coronary artery disease, epilepsy and parkinsonism.
Bethanechol chloride should not be employed when the strength or integrity of the gastrointestinal or bladder wall is in question, or in the presence of mechanical obstruction; when increased muscular activity of the gastrointestinal tract or urinary bladder might prove harmful, as following recent urinary bladder surgery, gastrointestinal resection and anastomosis, or when there is possible gastrointestinal obstruction; in bladder neck obstruction, spastic gastrointestinal disturbances, acute inflammatory lesions of the gastrointestinal tract, or peritonitis; or in marked vagotonia.
What are the warnings of Urecholine?
Sorry No Records found
What are the precautions of Urecholine?
General
In urinary retention, if the sphincter fails to relax as bethanechol chloride contracts the bladder, urine may be forced up the ureter into the kidney pelvis. If there is bacteriuria, this may cause reflux infection.
Information for Patients
Bethanechol chloride should preferably be taken one hour before or two hours after meals to avoid nausea or vomiting. Dizziness, lightheadedness or fainting may occur, especially when getting up from a lying or sitting position.
Drug Interactions
Special care is required if this drug is given to patients receiving ganglion blocking compounds because a critical fall in blood pressure may occur. Usually, severe abdominal symptoms appear before there is such a fall in the blood pressure.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term studies in animals have not been performed to evaluate the effects upon fertility, mutagenic or carcinogenic potential of bethanechol chloride.
Pregnancy
Animal reproduction studies have not been conducted with bethanechol chloride. It is also not known whether bethanechol chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Bethanechol chloride should be given to a pregnant woman only if clearly needed.
Nursing Mothers
It is not known whether this drug is secreted in human milk. Because many drugs are secreted in human milk and because of the potential for serious adverse reactions from bethanechol chloride in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
What are the side effects of Urecholine?
Adverse reactions are rare following oral administration of bethanechol chloride, but are more common following subcutaneous injection. Adverse reactions are more likely to occur when dosage is increased.
The following adverse reactions have been observed:
Body as a Whole: malaise
Digestive: abdominal cramps or discomfort, colicky pain, nausea and belching, diarrhea, borborygmi, salivation
Renal: urinary urgency
Nervous System: headache
Cardiovascular: a fall in blood pressure with reflex tachycardia, vasomotor response
Skin: flushing producing a feeling of warmth, sensation of heat about the face, sweating
Respiratory: bronchial constriction, asthmatic attacks
Special Senses: lacrimation, miosis
Causal Relationship Unknown:
The following adverse reactions have been reported, and a causal relationship to therapy with bethanechol chloride has not been established:
Body as a Whole: malaise
Nervous System: seizures
What should I look out for while using Urecholine?
Hypersensitivity to bethanechol chloride, hyperthyroidism, peptic ulcer, latent or active bronchial asthma, pronounced bradycardia or hypotension, vasomotor instability, coronary artery disease, epilepsy and parkinsonism.
Bethanechol chloride should not be employed when the strength or integrity of the gastrointestinal or bladder wall is in question, or in the presence of mechanical obstruction; when increased muscular activity of the gastrointestinal tract or urinary bladder might prove harmful, as following recent urinary bladder surgery, gastrointestinal resection and anastomosis, or when there is possible gastrointestinal obstruction; in bladder neck obstruction, spastic gastrointestinal disturbances, acute inflammatory lesions of the gastrointestinal tract, or peritonitis; or in marked vagotonia.
What might happen if I take too much Urecholine?
Early signs of overdosage are abdominal discomfort, salivation, flushing of the skin (“hot feeling”), sweating, nausea, and vomiting.
Atropine sulfate is a specific antidote. The recommended dose for adults is 0.6 mg. Repeat doses can be given every two hours, according to clinical response. The recommended dosage in infants and children up to 12 years of age is 0.01 mg/kg (to a maximum single dose of 0.4 mg) repeated every two hours as needed until the desired effect is obtained or adverse effects of atropine preclude further usage. Subcutaneous injection of atropine is preferred except in emergencies when the intravenous route may be employed.
The oral LD of bethanechol chloride is 1510 mg/kg in the mouse.
How should I store and handle Urecholine?
Urecholine (Bethanechol Chloride Tablets USP) is available as follows:5 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/697 on the 10 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/703 on the 25 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/704 on the 50 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/700 on the Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDRENTEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. A 9/2015Urecholine (Bethanechol Chloride Tablets USP) is available as follows:5 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/697 on the 10 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/703 on the 25 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/704 on the 50 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/700 on the Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDRENTEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. A 9/2015Urecholine (Bethanechol Chloride Tablets USP) is available as follows:5 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/697 on the 10 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/703 on the 25 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/704 on the 50 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/700 on the Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDRENTEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. A 9/2015Urecholine (Bethanechol Chloride Tablets USP) is available as follows:5 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/697 on the 10 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/703 on the 25 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/704 on the 50 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/700 on the Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDRENTEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. A 9/2015Urecholine (Bethanechol Chloride Tablets USP) is available as follows:5 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/697 on the 10 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/703 on the 25 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/704 on the 50 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/700 on the Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDRENTEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. A 9/2015Urecholine (Bethanechol Chloride Tablets USP) is available as follows:5 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/697 on the 10 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/703 on the 25 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/704 on the 50 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/700 on the Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDRENTEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. A 9/2015Urecholine (Bethanechol Chloride Tablets USP) is available as follows:5 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/697 on the 10 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/703 on the 25 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/704 on the 50 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/700 on the Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDRENTEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. A 9/2015Urecholine (Bethanechol Chloride Tablets USP) is available as follows:5 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/697 on the 10 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/703 on the 25 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/704 on the 50 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/700 on the Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDRENTEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. A 9/2015Urecholine (Bethanechol Chloride Tablets USP) is available as follows:5 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/697 on the 10 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/703 on the 25 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/704 on the 50 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/700 on the Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDRENTEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. A 9/2015Urecholine (Bethanechol Chloride Tablets USP) is available as follows:5 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/697 on the 10 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/703 on the 25 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/704 on the 50 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/700 on the Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDRENTEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. A 9/2015Urecholine (Bethanechol Chloride Tablets USP) is available as follows:5 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/697 on the 10 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/703 on the 25 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/704 on the 50 mg: Yellow, round, flat-face, beveled edge, scored tablet. Debossed with OP/700 on the Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDRENTEVA PHARMACEUTICALS USA, INC.North Wales, PA 19454Rev. A 9/2015