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UROGESIC BLUE
Overview
What is UROGESIC BLUE?
Inactive ingredients include
HYOSCYAMINE SULFATE is an alkaloid of belladonna. Exists as a white crystalline powder. Affected by light. It is very soluble in water; freely soluble in alcohol; practically insoluble in ether.
METHENAMINE exists as colorless, lustrous crystals or white crystalline powder. Its solutions are alkaline to litmus. Freely soluble in water; soluble in alcohol and in chloroform.
METHYLENE BLUE exists as dark green crystals. It is soluble in water and in chloroform; sparingly soluble in alcohol.
MONOBASIC SODIUM PHOSPHATE exists as a white crystalline powder. Its solutions are acidic to litmus. It is freely soluble in water and practically insoluble in alcohol.
What does UROGESIC BLUE look like?
What are the available doses of UROGESIC BLUE?
Sorry No records found.
What should I talk to my health care provider before I take UROGESIC BLUE?
Sorry No records found
How should I use UROGESIC BLUE?
UROGESIC-BLUE™
One tablet orally 4 times per day followed by liberal fluid intake.
What interacts with UROGESIC BLUE?
UROGESIC-BLUE™
What are the warnings of UROGESIC BLUE?
Anaphylaxis can occur following the administration of dacarbazine for injection.
What are the precautions of UROGESIC BLUE?
Cross sensitivity and/or related problems
patients intolerant of belladonna alkaloids may be intolerant of this medication also.
Pregnancy/Reproduction
hyoscyamine and methenamine cross the placenta. Studies have not been done in animals or humans. It is not known whethertablets cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.tablets should be given to a pregnant woman only if clearly needed.
Breast-feeding
problems in humans have not been documented; however, methenamine and traces of hyoscyamine are excreted in breast milk.
Prolonged use
there have been no studies to establish the safety of prolonged use in humans. No known long-term animal studies have been performed to evaluate carcinogenic potential.
Pediatric
infants and young children are especially susceptible to the toxic effect of the belladonna alkaloids.
Geriatric
use with caution in elderly patients as they may respond to usual doses of hyoscyamine with excitement, agitation, drowsiness, or confusion.
Drug Interactions
because of this product's effect on gastrointestinal motility and gastric emptying, it may decrease the absorption of other oral medications during concurrent use such as: urinary alkalizers; thiazide diuretics (may cause the urine to become alkaline reducing the effectiveness of methenamine by inhibiting its conversion to formaldehyde); antimuscarinics (concurrent use may intensify antimuscarinic effects of hyoscyamine because of secondary antimuscarinic activities of these medications); antacids/antidiarrheals (may reduce absorption of hyoscyamine, concurrent use with antacids may cause urine to become alkaline reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde) doses of these medications should be spaced 1 hour apart from doses of hyoscyamine; antimyasthenics (concurrent use with hyoscyamine may further reduce intestinal motility); ketoconazole (patients should be advised to take this combination at least 2 hours after ketoconazole); monoamine oxidase (MAO) Inhibitors (concurrent use may intensify antimuscarinic side effects, opoid (narcotic) analgesics may result in increased risk of severe constipation); sulfonamides (these drugs may precipitate with formaldehyde in the urine, increasing the danger of crystalluria).
Patients should be advised that the urine may become blue to blue green and the feces may be discolored as a result of the excretion of methylene blue.
What are the side effects of UROGESIC BLUE?
Cardiovascular
Central Nervous System
Respiratory
Genitourinary
Gastrointestinal
What should I look out for while using UROGESIC BLUE?
UROGESIC-BLUE™
Do not exceed recommended dosage. If rapid pulse, dizziness, or blurring of vision occurs
What might happen if I take too much UROGESIC BLUE?
Emesis or gastric lavage. Slow intravenous administration of physostigmine in doses of 1 mg to 4 mg (0.5 mg to 1 mg in children), repeated as needed in one to two hours to reverse severe antimuscarinic symptoms. Administration of small doses of diazepam to control excitement and seizures. Artificial respiration with oxygen if needed for respiratory depression. Adequate hydration. Symptomatic treatment as necessary.
How should I store and handle UROGESIC BLUE?
Store at 25° C (77° F); excursions permitted to 15° C to 30° C (59° F to 86° F) [See USP Controlled Room Temperature]. Keep container tightly closed.UROGESIC-BLUE™ are light blue to blue, oval, biconvex tablets debossed with "ED UB" with scoreline on one side and plain on the other side. Supplied in bottles of 30 tablets (NDC 0485-0151-30).
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
HYOSCYAMINE is a parasympatholytic which relaxes smooth muscles and thus produces an antispasmodic effect. It is well absorbed from the gastrointestinal tract and is rapidly distributed throughout body tissues. Most is excreted in the urine within 12 hours, 13% to 50% being unchanged. Its biotransformation is hepatic. Its protein binding is moderate.
METHENAMINE degrades in an acidic urine environment releasing formaldehyde which provides bactericidal or bacteriostatic action. It is well absorbed from the gastrointestinal tract. 70% to 90% reaches the urine unchanged at which point it is hydrolyzed if the urine is acidic. Within 24 hours it is almost completely (90%) excreted; of this amount at pH 5, approximately 20% is formaldehyde. Protein binding: some formaldehyde is bound to substances in the urine and surrounding tissues. Methenamine is freely distributed to body tissue and fluids but is not clinically significant as it does not hydrolyze at pH greater than 6.8.
METHYLENE BLUE possesses weak antiseptic properties. It is well absorbed in the gastrointestinal tract and is rapidly reduced to leukomethylene blue which is stabilized in some combination form in the urine. 75% is excreted unchanged.
MONOBASIC SODIUM PHOSPHATE helps to maintain an acid pH in the urine necessary for the degradation of methenamine.
Non-Clinical Toxicology
UROGESIC-BLUE™Do not exceed recommended dosage. If rapid pulse, dizziness, or blurring of vision occurs
because of this product's effect on gastrointestinal motility and gastric emptying, it may decrease the absorption of other oral medications during concurrent use such as: urinary alkalizers; thiazide diuretics (may cause the urine to become alkaline reducing the effectiveness of methenamine by inhibiting its conversion to formaldehyde); antimuscarinics (concurrent use may intensify antimuscarinic effects of hyoscyamine because of secondary antimuscarinic activities of these medications); antacids/antidiarrheals (may reduce absorption of hyoscyamine, concurrent use with antacids may cause urine to become alkaline reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde) doses of these medications should be spaced 1 hour apart from doses of hyoscyamine; antimyasthenics (concurrent use with hyoscyamine may further reduce intestinal motility); ketoconazole (patients should be advised to take this combination at least 2 hours after ketoconazole); monoamine oxidase (MAO) Inhibitors (concurrent use may intensify antimuscarinic side effects, opoid (narcotic) analgesics may result in increased risk of severe constipation); sulfonamides (these drugs may precipitate with formaldehyde in the urine, increasing the danger of crystalluria).
Patients should be advised that the urine may become blue to blue green and the feces may be discolored as a result of the excretion of methylene blue.
patients intolerant of belladonna alkaloids may be intolerant of this medication also.
Cardiovascular
Central Nervous System
Respiratory
Genitourinary
Gastrointestinal
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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