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VELTASSA

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Overview

What is VELTASSA?

Veltassa is a powder for suspension in water for oral administration. The active ingredient is patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patiromer is equivalent to a nominal amount of 2 grams of patiromer sorbitex calcium.

The chemical name for patiromer sorbitex calcium is cross-linked polymer of calcium 2-fluoroprop-2-enoate with diethenylbenzene and octa-1,7-diene, combination with D-glucitol.

Patiromer sorbitex calcium is an amorphous, free-flowing powder that is composed of individual spherical beads. Patiromer sorbitex calcium is insoluble in solvents such as water, 0.1 M HCl, n-heptane and methanol. The chemical structure of patiromer sorbitex calcium is presented in Figure 1.

Figure 1: Chemical Structure of Patiromer Sorbitex Calcium

Each packet of Veltassa contains 8.4 grams, 16.8 grams or 25.2 grams of patiromer, the active moiety. The inactive ingredient is xanthan gum.



What does VELTASSA look like?



What are the available doses of VELTASSA?

Veltassa is an off-white to light-brown powder for oral suspension packaged in single-use packets containing 8.4 grams, 16.8 grams or 25.2 grams patiromer.

What should I talk to my health care provider before I take VELTASSA?

How should I use VELTASSA?

Veltassa is indicated for the treatment of hyperkalemia.

Limitation of Use: Veltassa should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action .

Administer Veltassa at least 3 hours before or 3 hours after other oral medications

Administer Veltassa with food. Do not heat Veltassa (e.g., microwave) or add to heated foods or liquids. Do not take Veltassa in its dry form.


What interacts with VELTASSA?

Sorry No Records found


What are the warnings of VELTASSA?

Sorry No Records found


What are the precautions of VELTASSA?

Sorry No Records found


What are the side effects of VELTASSA?

Sorry No records found


What should I look out for while using VELTASSA?

Veltassa is contraindicated in patients with a history of a hypersensitivity reaction to Veltassa or any of its components


What might happen if I take too much VELTASSA?

Doses of Veltassa in excess of 50.4 grams per day have not been tested. Excessive doses of Veltassa may result in hypokalemia. Restore serum potassium if hypokalemia occurs.


How should I store and handle VELTASSA?

Veltassa should be stored in the refrigerator at 2°C to 8°C (36°F to 46°F). If stored at room temperature (25°C ± 2°C [77°F ± 4°F]), Veltassa must be used within 3 months of being taken out of the refrigerator. For either storage condition, do not use Veltassa after the expiration date printed on the packet.Avoid exposure to excessive heat above 40°C (104°F).Veltassa should be stored in the refrigerator at 2°C to 8°C (36°F to 46°F). If stored at room temperature (25°C ± 2°C [77°F ± 4°F]), Veltassa must be used within 3 months of being taken out of the refrigerator. For either storage condition, do not use Veltassa after the expiration date printed on the packet.Avoid exposure to excessive heat above 40°C (104°F).Veltassa should be stored in the refrigerator at 2°C to 8°C (36°F to 46°F). If stored at room temperature (25°C ± 2°C [77°F ± 4°F]), Veltassa must be used within 3 months of being taken out of the refrigerator. For either storage condition, do not use Veltassa after the expiration date printed on the packet.Avoid exposure to excessive heat above 40°C (104°F).Sevelamer Carbonate Tablets, 800 mg Unit dose packages of 100 (25 x 4) NDC 60687-328-31Storage: Store atFOR YOUR PROTECTION:Sevelamer Carbonate Tablets, 800 mg Unit dose packages of 100 (25 x 4) NDC 60687-328-31Storage: Store atFOR YOUR PROTECTION:Sevelamer Carbonate Tablets, 800 mg Unit dose packages of 100 (25 x 4) NDC 60687-328-31Storage: Store atFOR YOUR PROTECTION:Sevelamer Carbonate Tablets, 800 mg Unit dose packages of 100 (25 x 4) NDC 60687-328-31Storage: Store atFOR YOUR PROTECTION:


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Veltassa is a non-absorbed, cation exchange polymer that contains a calcium-sorbitol counterion.

Veltassa increases fecal potassium excretion through binding of potassium in the lumen of the gastrointestinal tract. Binding of potassium reduces the concentration of free potassium in the gastrointestinal lumen, resulting in a reduction of serum potassium levels.

Non-Clinical Toxicology
Veltassa is contraindicated in patients with a history of a hypersensitivity reaction to Veltassa or any of its components

Large doses of naloxone are required to antagonize buprenorphine since the latter has a long duration of action due to its slow rate of binding and subsequent slow dissociation from the opioid receptor. Buprenorphine antagonism is characterized by a gradual onset of the reversal effects and a decreased duration of action of the normally prolonged respiratory depression. The barbiturate methohexital appears to block the acute onset of withdrawal symptoms induced by naloxone in opiate addicts.

Avoid use of Veltassa in patients with severe constipation, bowel obstruction or impaction, including abnormal post-operative bowel motility disorders, because Veltassa may be ineffective and may worsen gastrointestinal conditions.

Patients with a history of bowel obstruction or major gastrointestinal surgery, severe gastrointestinal disorders, or swallowing disorders were not included in the clinical studies.

The following adverse reaction is discussed in greater detail elsewhere in the label:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

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Tips

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Interactions

Interactions

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