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What is Verzenio?

Abemaciclib is a kinase inhibitor for oral administration. It is a white to yellow powder with the empirical formula CHFN and a molecular weight 506.59.

The chemical name for abemaciclib is 2-Pyrimidinamine, -[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1-benzimidazol-6-yl]-. Abemaciclib has the following structure:

VERZENIO (abemaciclib) tablets are provided as immediate-release oval white, beige, or yellow tablets. Inactive ingredients are as follows: Excipients—microcrystalline cellulose 102, microcrystalline cellulose 101, lactose monohydrate, croscarmellose sodium, sodium stearyl fumarate, silicon dioxide. Color mixture ingredients—polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, iron oxide yellow, and iron oxide red.

What does Verzenio look like?

What are the available doses of Verzenio?

Tablets: 50 mg, 100 mg, 150 mg, and 200 mg. ()

What should I talk to my health care provider before I take Verzenio?

Lactation: Advise not to breastfeed. ()

How should I use Verzenio?

VERZENIO™ (abemaciclib) is indicated:

When used in combination with fulvestrant or an aromatase inhibitor, the recommended dose of VERZENIO is 150 mg taken orally twice daily.

When used as monotherapy, the recommended dose of VERZENIO is 200 mg taken orally twice daily.

Continue treatment until disease progression or unacceptable toxicity. VERZENIO may be taken with or without food .

Instruct patients to take their doses of VERZENIO at approximately the same times every day.

If the patient vomits or misses a dose of VERZENIO, instruct the patient to take the next dose at its scheduled time. Instruct patients to swallow VERZENIO tablets whole and not to chew, crush, or split tablets before swallowing. Instruct patients not to ingest VERZENIO tablets if broken, cracked, or otherwise not intact.

What interacts with Verzenio?

Sorry No Records found

What are the warnings of Verzenio?

Sorry No Records found

What are the precautions of Verzenio?

Sorry No Records found

What are the side effects of Verzenio?

Sorry No records found

What should I look out for while using Verzenio?


What might happen if I take too much Verzenio?

There is no known antidote for VERZENIO. The treatment of overdose of VERZENIO should consist of general supportive measures.

How should I store and handle Verzenio?

Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Product: 50090-3019NDC: 50090-3019-0 60 TABLET in a BOTTLEProduct: 50090-3019NDC: 50090-3019-0 60 TABLET in a BOTTLE


Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Abemaciclib is an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6). These kinases are activated upon binding to D-cyclins. In estrogen receptor-positive (ER+) breast cancer cell lines, cyclin D1 and CDK4/6 promote phosphorylation of the retinoblastoma protein (Rb), cell cycle progression, and cell proliferation. In vitro, continuous exposure to abemaciclib inhibited Rb phosphorylation and blocked progression from G1 into S phase of the cell cycle, resulting in senescence and apoptosis. In breast cancer xenograft models, abemaciclib dosed daily without interruption as a single agent or in combination with antiestrogens resulted in reduction of tumor size.

Non-Clinical Toxicology

Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline. Subtherapeutic prothrombin times with concomitant warfarin and sucralfate therapy have been reported in spontaneous and published case reports. However, two clinical studies have demonstrated no change in either serum warfarin concentration or prothrombin time with the addition of sucralfate to chronic warfarin therapy.

The mechanism of these interactions appears to be nonsystemic in nature, presumably resulting from sucralfate binding to the concomitant agent in the gastrointestinal tract. In all case studies to date (cimetidine, ciprofloxacin, digoxin, norfloxacin, ofloxacin, and ranitidine), dosing the concomitant medication 2 hours before sucralfate eliminated the interaction. Because of the potential of sucralfate to alter the absorption of some drugs, sucralfate should be administered separately from other drugs when alterations in bioavailability are felt to be critical. In these cases, patients should be monitored appropriately.

[see Dosage and Administration () and Patient Counseling Information ()]

Instruct patients that at the first sign of loose stools, they should start antidiarrheal therapy such as loperamide, increase oral fluids, and notify their healthcare provider for further instructions and appropriate follow up. For Grade 3 or 4 diarrhea, or diarrhea that requires hospitalization, discontinue VERZENIO until toxicity resolves to ≤Grade 1, and then resume VERZENIO at the next lower dose .

The following adverse reactions are discussed in greater detail in other sections of the labeling:



This information is obtained from the National Institute of Health's Standard Packaging Label drug database.

While we update our database periodically, we cannot guarantee it is always updated to the latest version.



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