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Vimpat

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Overview

What is Vimpat?

The chemical name of lacosamide, the single (R)-enantiomer, is (R)-2-acetamido-N-benzyl-3-methoxypropionamide (IUPAC). Lacosamide is a functionalized amino acid. Its molecular formula is C H N O and its molecular weight is 250.30. The chemical structure is:

Lacosamide is a white to light yellow powder. It is sparingly soluble in water and slightly soluble in acetonitrile and ethanol.



What does Vimpat look like?



What are the available doses of Vimpat?

VIMPAT Tablets

VIMPAT Injection

VIMPAT Oral Solution

What should I talk to my health care provider before I take Vimpat?

How should I use Vimpat?

VIMPAT is indicated for the treatment of partial-onset seizures in patients 4 years of age and older.

As the safety of VIMPAT injection in pediatric patients has not been established, VIMPAT injection is indicated for the treatment of partial-onset seizures only in adult patients (17 years of age and older).

Adults (17 years and older):

Pediatric Patients 4 Years to less than 17 years

Increase dosage based on clinical response and tolerability, no more frequently than once per week ( )

Injection: for intravenous and adult use only when oral administration is temporarily not feasible; dosing regimen is the same as oral regimen; administer over 15 to 60 minutes; obtaining ECG before initiation is recommended in certain patients ( , )

Dose adjustment is recommended for severe renal impairment ( , )

Dose adjustment is recommended for mild or moderate hepatic impairment; use in patients with severe hepatic impairment is not recommended ( , )


What interacts with Vimpat?

Sorry No Records found


What are the warnings of Vimpat?

Sorry No Records found


What are the precautions of Vimpat?

Sorry No Records found


What are the side effects of Vimpat?

Sorry No records found


What should I look out for while using Vimpat?

None


What might happen if I take too much Vimpat?

Events reported after an intake of more than 800 mg (twice the maximum recommended daily dosage) of VIMPAT include dizziness, nausea, and seizures (generalized tonic-clonic seizures, status epilepticus). Cardiac conduction disorders, confusion, decreased level of consciousness, cardiogenic shock, and coma have also been observed. Fatalities have occurred following lacosamide overdoses of several grams.

There is no specific antidote for overdose with VIMPAT. Standard decontamination procedures should be followed. General supportive care of the patient is indicated including monitoring of vital signs and observation of the clinical status of patient. A Certified Poison Control Center should be contacted for up to date information on the management of overdose with VIMPAT.

Standard hemodialysis procedures result in significant clearance of VIMPAT (reduction of systemic exposure by 50% in 4 hours). Hemodialysis may be indicated based on the patient's clinical state or in patients with significant renal impairment.


How should I store and handle Vimpat?

Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F).[See USP Controlled Room Temperature]Do not freeze VIMPAT injection or oral solution. Discard any unused VIMPAT oral solution remaining after seven (7) weeks of first opening the bottle.Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F).[See USP Controlled Room Temperature]Do not freeze VIMPAT injection or oral solution. Discard any unused VIMPAT oral solution remaining after seven (7) weeks of first opening the bottle.Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F).[See USP Controlled Room Temperature]Do not freeze VIMPAT injection or oral solution. Discard any unused VIMPAT oral solution remaining after seven (7) weeks of first opening the bottle.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:NDC 65841-729-06 in bottle of 30 tabletsNDC 65841-729-16 in bottle of 90 tabletsNDC 65841-729-01 in bottle of 100 tabletsNDC 65841-729-10 in bottle of 1,000 tabletsNDC 65841-729-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:NDC 65841-730-06 in bottle of 30 tabletsNDC 65841-730-16 in bottle of 90 tabletsNDC 65841-730-01 in bottle of 100 tabletsNDC 65841-730-10 in bottle of 1,000 tabletsNDC 65841-730-24 in bottle of 10,000 tabletsLosartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 65841-731-06 in bottle of 30 tabletsNDC 65841-731-16 in bottle of 90 tabletsNDC 65841-731-01 in bottle of 100 tabletsNDC 65841-731-10 in bottle of 1,000 tabletsNDC 65841-731-40 in bottle of 5,000 tabletsNDC 65841-731-77 in cartons of 100 tablets (10 x 10 unit-dose)Storage:Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.Dispense in a tight, light-resistant container.


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Clinical Information

Chemical Structure

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Clinical Pharmacology

The precise mechanism by which VIMPAT exerts its antiepileptic effects in humans remains to be fully elucidated. electrophysiological studies have shown that lacosamide selectively enhances slow inactivation of voltage-gated sodium channels, resulting in stabilization of hyperexcitable neuronal membranes and inhibition of repetitive neuronal firing.

Non-Clinical Toxicology
None

As with all drugs, the potential exists for interaction with other drugs by a variety of mechanisms.

Antiepileptic drugs (AEDs), including VIMPAT, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication. Patients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.

Pooled analyses of 199 placebo-controlled clinical trials (mono- and adjunctive therapy) of 11 different AEDs showed that patients randomized to one of the AEDs had approximately twice the risk (adjusted Relative Risk 1.8, 95% CI:1.2, 2.7) of suicidal thinking or behavior compared to patients randomized to placebo. In these trials, which had a median treatment duration of 12 weeks, the estimated incidence of suicidal behavior or ideation among 27,863 AED-treated patients was 0.43%, compared to 0.24% among 16,029 placebo-treated patients, representing an increase of approximately one case of suicidal thinking or behavior for every 530 patients treated. There were four suicides in drug-treated patients in the trials and none in placebo-treated patients, but the number of events is too small to allow any conclusion about drug effect on suicide.

The increased risk of suicidal thoughts or behavior with AEDs was observed as early as one week after starting treatment with AEDs and persisted for the duration of treatment assessed. Because most trials included in the analysis did not extend beyond 24 weeks, the risk of suicidal thoughts or behavior beyond 24 weeks could not be assessed.

The risk of suicidal thoughts or behavior was generally consistent among drugs in the data analyzed. The finding of increased risk with AEDs of varying mechanisms of action and across a range of indications suggests that the risk applies to all AEDs used for any indication. The risk did not vary substantially by age (5-100 years) in the clinical trials analyzed.

Table 2 shows absolute and relative risk by indication for all evaluated AEDs.

The relative risk for suicidal thoughts or behavior was higher in clinical trials for epilepsy than in clinical trials for psychiatric or other conditions, but the absolute risk differences were similar.

Anyone considering prescribing VIMPAT or any other AED must balance this risk with the risk of untreated illness. Epilepsy and many other illnesses for which antiepileptics are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior. Should suicidal thoughts and behavior emerge during treatment, the prescriber needs to consider whether the emergence of these symptoms in any given patient may be related to the illness being treated.

Patients, their caregivers, and families should be informed that AEDs increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of the signs and symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts, behavior, or thoughts about self-harm. Behaviors of concern should be reported immediately to healthcare providers.

The following serious adverse reactions are described below and elsewhere in the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).