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Voriconazole

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Overview

What is Voriconazole?

Voriconazole, USP, an azole antifungal agent is available as a powder for oral suspension. The structural formula is:

Voriconazole, USP is designated chemically as (2R,3S)-2-(2, 4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1-1,2,4-triazol-1-yl)-2-butanol with an empirical formula of CHFNO and a molecular weight of 349.3.

Voriconazole, USP drug substance is a white to light-colored powder.

Voriconazole for Oral Suspension is a white to off-white powder providing a white to off-white orange-flavored suspension when reconstituted. Bottles containing 45 g powder for oral suspension are intended for reconstitution with water to produce a suspension containing 40 mg/mL voriconazole, USP. The inactive ingredients include anhydrous citric acid, colloidal silicon dioxide, natural and artificial orange flavor, sodium benzoate, sodium citrate, sucrose, titanium dioxide and xanthan gum.



What does Voriconazole look like?



What are the available doses of Voriconazole?

Powder for Oral Suspension

Voriconazole for Oral Suspension is supplied in 100 mL high density polyethylene (HDPE) bottles. Each bottle contains 45 g of powder for oral suspension. Following reconstitution, the volume of the suspension is 75 mL, providing a usable volume of 70 mL (40 mg voriconazole/mL). A 5 mL oral dispenser and a press-in bottle adaptor are also provided.

What should I talk to my health care provider before I take Voriconazole?

How should I use Voriconazole?

Voriconazole for oral suspension is indicated for use in patients 12 years of age and older in the treatment of the following fungal infections:

Voriconazole for oral suspension should be taken at least one hour before or after a meal.


What interacts with Voriconazole?

Sorry No Records found


What are the warnings of Voriconazole?

Sorry No Records found


What are the precautions of Voriconazole?

Sorry No Records found


What are the side effects of Voriconazole?

Sorry No records found


What should I look out for while using Voriconazole?

Hypersensitivity to voriconazole or its excipients.

Co-administration with terfenadine, astemizole, cisapride, pimozide or quinidine, sirolimus due to risk of serious adverse reactions.  

Co-administration with rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids, and St. John’s Wort due to risk of loss of efficacy.  


What might happen if I take too much Voriconazole?

In clinical trials, there were three cases of accidental overdose. All occurred in pediatric patients who received up to five times the recommended intravenous dose of voriconazole. A single adverse event of photophobia of 10 minutes duration was reported.

There is no known antidote to voriconazole.

Voriconazole is hemodialyzed with clearance of 121 mL/min. The intravenous vehicle, SBECD, is hemodialyzed with clearance of 55 mL/min. In an overdose, hemodialysis may assist in the removal of voriconazole and SBECD from the body.


How should I store and handle Voriconazole?

Store in a dry place at 25°C (77°F); excursions permitted to 15-30°C (59-86° F) [see USP Controlled Room Temperature]. 75 mcg: Protect capsule from light and moisture. Keep out of the reach of children. Store in a dry place at 25°C (77°F); excursions permitted to 15-30°C (59-86° F) [see USP Controlled Room Temperature]. 75 mcg: Protect capsule from light and moisture. Keep out of the reach of children. Store in a dry place at 25°C (77°F); excursions permitted to 15-30°C (59-86° F) [see USP Controlled Room Temperature]. 75 mcg: Protect capsule from light and moisture. Keep out of the reach of children. Rosuvastatin Calcium Tablets, 10 mg Bottles of 30                              NDC 68788-6321-3Bottles of 60                              NDC 68788-6321-6Bottles of 90                              NDC 68788-6321-9 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Protect from moisture.Rosuvastatin Calcium Tablets, 10 mg Bottles of 30                              NDC 68788-6321-3Bottles of 60                              NDC 68788-6321-6Bottles of 90                              NDC 68788-6321-9 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Protect from moisture.Rosuvastatin Calcium Tablets, 10 mg Bottles of 30                              NDC 68788-6321-3Bottles of 60                              NDC 68788-6321-6Bottles of 90                              NDC 68788-6321-9 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Protect from moisture.Rosuvastatin Calcium Tablets, 10 mg Bottles of 30                              NDC 68788-6321-3Bottles of 60                              NDC 68788-6321-6Bottles of 90                              NDC 68788-6321-9 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Protect from moisture.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Voriconazole is an antifungal drug [ ].

Non-Clinical Toxicology
Hypersensitivity to voriconazole or its excipients.

Co-administration with terfenadine, astemizole, cisapride, pimozide or quinidine, sirolimus due to risk of serious adverse reactions.  

Co-administration with rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids, and St. John’s Wort due to risk of loss of efficacy.  

See Table 7 for a listing of drugs that may significantly alter voriconazole concentrations. Also, see Table 8 for a listing of drugs that may interact with voriconazole resulting in altered pharmacokinetics or pharmacodynamics of the other drug [ and ].

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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