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Vosevi

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Overview

What is Vosevi?

VOSEVI is a fixed-dose combination tablet containing sofosbuvir, velpatasvir, and voxilaprevir for oral administration. Sofosbuvir is a nucleotide analog HCV NS5B polymerase inhibitor, velpatasvir is an NS5A inhibitor, and voxilaprevir is an NS3/4A protease inhibitor.

Each tablet contains 400 mg sofosbuvir, 100 mg velpatasvir, and 100 mg of voxilaprevir. The tablets include the following inactive ingredients: colloidal silicon dioxide, copovidone, croscarmellose sodium, lactose monohydrate, magnesium stearate, and microcrystalline cellulose. The tablets are film-coated with a coating material containing the following inactive ingredients: ferrosoferric oxide, iron oxide red, iron oxide yellow, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.



What does Vosevi look like?



What are the available doses of Vosevi?

Tablets: 400 mg sofosbuvir, 100 mg velpatasvir, and 100 mg voxilaprevir

What should I talk to my health care provider before I take Vosevi?

How should I use Vosevi?

VOSEVI is indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) infection without cirrhosis or with compensated cirrhosis (Child-Pugh A) who have

Test all patients for evidence of current or prior HBV infection by measuring hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) before initiating HCV treatment with VOSEVI


What interacts with Vosevi?

Sorry No Records found


What are the warnings of Vosevi?

Sorry No Records found


What are the precautions of Vosevi?

Sorry No Records found


What are the side effects of Vosevi?

Sorry No records found


What should I look out for while using Vosevi?

VOSEVI is contraindicated with rifampin

Test all patients for evidence of current or prior hepatitis B virus (HBV) infection before initiating treatment with VOSEVI. HBV reactivation has been reported in HCV/HBV coinfected patients who were undergoing or had completed treatment with HCV direct-acting antivirals (DAA) and were not receiving HBV antiviral therapy. Some cases have resulted in fulminant hepatitis, hepatic failure, and death. Monitor HCV/HBV coinfected patients for hepatitis flare or HBV reactivation during HCV treatment and post-treatment follow-up. Initiate appropriate patient management for HBV infection as clinically indicated


What might happen if I take too much Vosevi?

No specific antidote is available for overdose with VOSEVI. If overdose occurs the patient must be monitored for evidence of toxicity. Treatment of overdose with VOSEVI consists of general supportive measures including monitoring of vital signs as well as observation of the clinical status of the patient. Hemodialysis can efficiently remove the predominant circulating metabolite of sofosbuvir, GS-331007, with an extraction ratio of 53%. Hemodialysis is unlikely to result in significant removal of velpatasvir or voxilaprevir since velpatasvir and voxilaprevir are highly bound to plasma protein.


How should I store and handle Vosevi?

Do not freeze BASAGLAR. Do not use BASAGLAR if it has been frozen. BASAGLAR must be protected from direct heat and light. Do not use after the expiration date. Storage conditions are summarized in the following table: Do not freeze BASAGLAR. Do not use BASAGLAR if it has been frozen. BASAGLAR must be protected from direct heat and light. Do not use after the expiration date. Storage conditions are summarized in the following table: Do not freeze BASAGLAR. Do not use BASAGLAR if it has been frozen. BASAGLAR must be protected from direct heat and light. Do not use after the expiration date. Storage conditions are summarized in the following table: Do not freeze BASAGLAR. Do not use BASAGLAR if it has been frozen. BASAGLAR must be protected from direct heat and light. Do not use after the expiration date. Storage conditions are summarized in the following table: Each VOSEVI tablet contains 400 mg of sofosbuvir, 100 mg of velpatasvir, and 100 mg of voxilaprevir. The tablets are beige, capsule-shaped, film-coated, and debossed with "GSI" on one side and "" on the other side. Each bottle contains 28 tablets (NDC 61958-2401-1), polyester coil, silica gel desiccant, and is closed with a child-resistant closure.