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wound debridement kit

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Overview

What is Wound Debridement Kit?

WOUND DEBRIDEMENT KIT® CONTAINS:

1-Lidocaine HCI Topical Solution, USP 4%

Lidocaine Hydrochloride Topical Solution USP 4% contains a local anesthetic agent and is administered topically. See for specific uses.

Each mL contains:

Lidocaine Hydrochloride . . . . . . . . . . .................................................................................... 40 mg

Methylparaben, Sodium Hydroxide (to adjust pH) in an aqueous solution. NOT FOR INJECTION.

Lidocaine is a local anesthetic chemically designated as 2-(diethylamino)-N-(2,6-dimethyl-phenyl)-acetamide. It has the following structural formula:

1 - Latex-Free, Powder Free Surgical Gloves

2 - Sterile Woven Gauze 4"x4"; 10 Pack

1 - Bandage Scissors

1 - Adson Forceps with Teeth

1 - Iris Scissors

2 - Dermal Curettes

1 - Sodium Calcium Alginate Dressing

1 - #10 Blade Scalpel

1 - #15 Blade Scalpel

1 - Wound Measurement Ruler

1 - Curved Hemostat

2 - OR Towels



What does Wound Debridement Kit look like?



What are the available doses of Wound Debridement Kit?

Sorry No records found.

What should I talk to my health care provider before I take Wound Debridement Kit?

Sorry No records found

How should I use Wound Debridement Kit?

Lidocaine Hydrochloride Topical Solution USP is indicated for the production of topical anesthesia of accessible mucous membranes of the oral and nasal cavities and proximal portions of the digestive tract.

When lidocaine hydrochloride topical solution 4% is used concomitantly with other products containing lidocaine, the total dose contributed by all formulations must be kept in mind.

The dosage varies and depends upon the area to be anesthetized, vascularity of the tissues, individual tolerance and the technique of anesthesia. The lowest dosage needed to provide effective anesthesia should be administered. Dosages should be reduced for children and for elderly and debilitated patients. The maximum dose should not exceed 4.5 mg/kg (2 mg/lb) of body weight. Although the incidence of adverse effects with lidocaine hydrochloride topical solution 4% is quite low, caution should be exercised particularly when employing large volumes since the incidence of adverse effects is directly proportional to the total dose of local anesthetic agent administered.

The dosages recommended below are for normal healthy adults:

When used as a spray, or when applied by means of cotton applicators or packs, as when instilled into a cavity, the suggested dosage of lidocaine hydrochloride topical solution is 1-5 mL (40-200 mg of lidocaine hydrochloride), i.e., 0.6-3.0 mg/kg or 0.3-1.5 mg/lb of body weight.

NOTE:

Maximum Recommended Dosages:


What interacts with Wound Debridement Kit?

Lidocaine Hydrochloride Topical Solution USP is contraindicated in patients with a known hypersensitivity either to local anesthetics of the amide type or to the components of the topical solution.



What are the warnings of Wound Debridement Kit?

Photosensitivity manifested by an exaggerated sunburn reaction has been observed in some individuals taking tetracyclines. Patients apt to be exposed to direct sunlight or ultraviolet light should be advised that this reaction can occur with tetracycline drugs, and treatment should be discontinued at the first evidence of skin erythema.

IN ORDER TO MANAGE POSSIBLE ADVERSE REACTIONS, RESUSCITATIVE EQUIPMENT, OXYGEN AND OTHER RESUSCITATIVE DRUGS MUST BE IMMEDIATELY AVAILABLE WHEN LOCAL ANESTHETIC AGENTS, SUCH AS LIDOCAINE, ARE ADMINISTERED TO MUCOUS MEMBRANES.

Lidocaine hydrochloride topical solution should be used with extreme caution if there is sepsis or severely traumatized mucosa in the area of application, since under such conditions there is the potential for rapid systemic absorption.


What are the precautions of Wound Debridement Kit?

General

The safety and effectiveness of lidocaine depend on proper dosage, correct technique, adequate precautions, and readiness for emergencies. Resuscitative equipment, oxygen, and other resuscitative drugs should be available for immediate use. (See and ). The lowest dosage that results in effective anesthesia should be used to avoid high plasma levels and serious adverse effects. Repeated doses of lidocaine may cause significant increases in blood levels with each repeated dose because of slow accumulation of the drug and/or its metabolites. Tolerance to elevated blood levels varies with the status of the patient. Debilitated, elderly patients, acutely ill patients, and children should be given reduced doses commensurate with their age and physical status. Lidocaine should also be used with caution in patients with severe shock or heart block.

Lidocaine hydrochloride topical solution should be used with caution in patients with known drug sensitivities. Patients allergic to para-aminobenzoic acid derivatives (procaine, tetracaine, benzocaine, etc.) have not shown cross sensitivity to lidocaine.

Although it has been shown that the rate of absorption of lidocaine after spraying the laryngotracheal mucosa with a solution of the local anesthetic agent is normally relatively slow, there is the attendant risk that occasionally some of the solution may gravitate into the lower respiratory tract where surface area for absorption and tissue blood flow are markedly greater. This can result in unexpectedly rapid and high blood levels, and this possibility must be kept in mind whenever lidocaine hydrochloride topical solution is administered.

Many drugs used during the conduct of anesthesia are considered potential triggering agents for familial malignant hyperthermia. Since it is not known whether amide-type local anesthetics may trigger this reaction and since the need for supplemental general anesthesia cannot be predicted in advance, it is suggested that a standard protocol for management should be available. Early unexplained signs of tachycardia, tachypnea, labile blood pressure and metabolic acidosis may precede temperature elevation. Successful outcome is dependent on early diagnosis, prompt discontinuance of the suspect triggering agent(s) and institution of treatment, including oxygen therapy, indicated supportive measures and dantrolene (consult dantrolene sodium intravenous package insert before using).

Information for Patients

When topical anesthetics are used in the mouth or throat, the patient should be aware that the production of topical anesthesia may impair swallowing and thus enhance the danger of aspiration. For this reason, food should not be ingested for 60 minutes following use of local anesthetic preparations in the mouth or throat area. This is particularly important in children because of their frequency of eating.

Numbness of the tongue or buccal mucosa may increase the danger of unintentional biting trauma. Food and chewing gum should not be taken while the mouth or throat area is anesthetized.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Studies of lidocaine in animals to evaluate the carcinogenic and mutagenic potential or the effect on fertility have not been conducted.

Use In Pregnancy

Reproduction studies have been performed in rats at doses up to 6.6 times the human dose and have revealed no evidence of harm to the fetus caused by lidocaine. There are, however, no adequate and well-controlled studies in pregnant women. Animal reproduction studies are not always predictive of human response. General consideration should be given to this fact before administering lidocaine to women of childbearing potential, especially during early pregnancy when maximum organogenesis takes place.

Labor and Delivery

Lidocaine is not contraindicated in labor and delivery. Should lidocaine hydrochloride topical solution be used concomitantly with other products containing lidocaine, the total dose being administered must be kept in mind.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when lidocaine is administered to a nursing woman.

Pediatric Use

Dosage in children should be reduced commensurate with age, body weight and physical conditions. See .


What are the side effects of Wound Debridement Kit?

Adverse experiences following the administration of lidocaine are similar in nature to those observed with other amide local anesthetic agents. These adverse experiences are, in general, dose-related and may result from high plasma levels caused by excessive dosage or rapid absorption, or may result from a hypersensitivity, idiosyncrasy or diminished tolerance on the part of the patient. Serious adverse experiences are generally systemic in nature. The following types are those most commonly reported:

Central nervous system

CNS manifestations are excitatory and/or depressant and may be characterized by lightheadedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest. The excitatory manifestations may be very brief or may not occur at all, in which case manifestation of toxicity may be drowsiness merging into unconsciousness and respiratory arrest.

Drowsiness following the administration of lidocaine is usually an early sign of a high blood level of the drug and may occur as a consequence of rapid absorption.




What should I look out for while using Wound Debridement Kit?

Lidocaine Hydrochloride Topical Solution USP is contraindicated in patients with a known hypersensitivity either to local anesthetics of the amide type or to the components of the topical solution.

IN ORDER TO MANAGE POSSIBLE ADVERSE REACTIONS, RESUSCITATIVE EQUIPMENT, OXYGEN AND OTHER RESUSCITATIVE DRUGS MUST BE IMMEDIATELY AVAILABLE WHEN LOCAL ANESTHETIC AGENTS, SUCH AS LIDOCAINE, ARE ADMINISTERED TO MUCOUS MEMBRANES.

Lidocaine hydrochloride topical solution should be used with extreme caution if there is sepsis or severely traumatized mucosa in the area of application, since under such conditions there is the potential for rapid systemic absorption.


What might happen if I take too much Wound Debridement Kit?

Sorry No Records found


How should I store and handle Wound Debridement Kit?

Protect from light. Store in a safe place out of the reach of children.Protect from light. Store in a safe place out of the reach of children.Protect from light. Store in a safe place out of the reach of children.Protect from light. Store in a safe place out of the reach of children.Protect from light. Store in a safe place out of the reach of children.Protect from light. Store in a safe place out of the reach of children.Protect from light. Store in a safe place out of the reach of children.KIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR TowelsKIT NDC# 69263-920-01WOUND DEBRIDEMENT KIT CONTAINS:1 Lidocaine HCl Topical Solution, USP 4%(NDC 0054-3505-47) Bottle of 50 mLStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Avoid freezing.10000088/04 Revised July 2012 © RLI, 2012)1 Latex-Free, Powder Free Surgical Gloves2 Sterile Woven Gauze 4"x4"; 10 Pack1 Bandage Scissors1 Adson Forceps with Teeth1 Iris Scissors2 Dermal Curettes1 Sodium Calcium Alginate Dressing1 #10 Blade Scalpel1 #15 Blade Scalpel1 Wound Measurement Ruler1 Curved Hemostat2 OR Towels


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action.

Non-Clinical Toxicology
Lidocaine Hydrochloride Topical Solution USP is contraindicated in patients with a known hypersensitivity either to local anesthetics of the amide type or to the components of the topical solution.

IN ORDER TO MANAGE POSSIBLE ADVERSE REACTIONS, RESUSCITATIVE EQUIPMENT, OXYGEN AND OTHER RESUSCITATIVE DRUGS MUST BE IMMEDIATELY AVAILABLE WHEN LOCAL ANESTHETIC AGENTS, SUCH AS LIDOCAINE, ARE ADMINISTERED TO MUCOUS MEMBRANES.

Lidocaine hydrochloride topical solution should be used with extreme caution if there is sepsis or severely traumatized mucosa in the area of application, since under such conditions there is the potential for rapid systemic absorption.

Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin.

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations.

Absorption of tetracyclines is impaired by bismuth subsalicylate.

Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.

The concurrent use of tetracycline and Penthrane (methoxyflurane) has been reported to result in fatal renal toxicity.

Concurrent use of tetracycline may render oral contraceptives less effective.

The safety and effectiveness of lidocaine depend on proper dosage, correct technique, adequate precautions, and readiness for emergencies. Resuscitative equipment, oxygen, and other resuscitative drugs should be available for immediate use. (See and ). The lowest dosage that results in effective anesthesia should be used to avoid high plasma levels and serious adverse effects. Repeated doses of lidocaine may cause significant increases in blood levels with each repeated dose because of slow accumulation of the drug and/or its metabolites. Tolerance to elevated blood levels varies with the status of the patient. Debilitated, elderly patients, acutely ill patients, and children should be given reduced doses commensurate with their age and physical status. Lidocaine should also be used with caution in patients with severe shock or heart block.

Lidocaine hydrochloride topical solution should be used with caution in patients with known drug sensitivities. Patients allergic to para-aminobenzoic acid derivatives (procaine, tetracaine, benzocaine, etc.) have not shown cross sensitivity to lidocaine.

Although it has been shown that the rate of absorption of lidocaine after spraying the laryngotracheal mucosa with a solution of the local anesthetic agent is normally relatively slow, there is the attendant risk that occasionally some of the solution may gravitate into the lower respiratory tract where surface area for absorption and tissue blood flow are markedly greater. This can result in unexpectedly rapid and high blood levels, and this possibility must be kept in mind whenever lidocaine hydrochloride topical solution is administered.

Many drugs used during the conduct of anesthesia are considered potential triggering agents for familial malignant hyperthermia. Since it is not known whether amide-type local anesthetics may trigger this reaction and since the need for supplemental general anesthesia cannot be predicted in advance, it is suggested that a standard protocol for management should be available. Early unexplained signs of tachycardia, tachypnea, labile blood pressure and metabolic acidosis may precede temperature elevation. Successful outcome is dependent on early diagnosis, prompt discontinuance of the suspect triggering agent(s) and institution of treatment, including oxygen therapy, indicated supportive measures and dantrolene (consult dantrolene sodium intravenous package insert before using).

Adverse experiences following the administration of lidocaine are similar in nature to those observed with other amide local anesthetic agents. These adverse experiences are, in general, dose-related and may result from high plasma levels caused by excessive dosage or rapid absorption, or may result from a hypersensitivity, idiosyncrasy or diminished tolerance on the part of the patient. Serious adverse experiences are generally systemic in nature. The following types are those most commonly reported:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).