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NORETHINDRONE AND ETHINYL ESTRADIOL

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Overview

What is WYMZYA Fe?

WYMZYA Fe is a combinational contraceptive containing the progestational compound norethindrone and the estrogenic compound ethinyl estradiol. The packaging includes 21 white tablets composed of norethindrone and ethinyl estradiol followed by 7 brown ferrous fumarate (placebo) tablets. The chemical name for norethindrone is 17-hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one and for ethinyl estradiol the chemical name is 19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17-diol. The structural formulas are:

The active white WYMZYA Fe tablets contain 0.4 mg norethindrone and 0.035 mg ethinyl estradiol, and the following inactive ingredients: lactose anhydrous, magnesium stearate, mannitol, microcrystalline cellulose, povidone, sodium starch glycolate, sucralose, vanillin and vitamin E.

The brown tablets contain ferrous fumarate, magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate and sucrose. The ferrous fumarate tablets do not serve any therapeutic purpose.



What does WYMZYA Fe look like?



What are the available doses of WYMZYA Fe?

WYMZYA Fe consists of 28 tablets in the following order ():

What should I talk to my health care provider before I take WYMZYA Fe?

WYMZYA Fe can decrease milk production. ()

How should I use WYMZYA Fe?

WYMZYA Fe is indicated for use by females of reproductive potential to prevent pregnancy.

WYMZYA Fe is dispensed in a wallet WYMZYA Fe may be started using either a Day 1 start or a Sunday start (see Table 1). For the first cycle of a Sunday Start regimen, an additional method of contraception should be used until after the first 7 consecutive days of administration.


What interacts with WYMZYA Fe?

Sorry No Records found


What are the warnings of WYMZYA Fe?

Sorry No Records found


What are the precautions of WYMZYA Fe?

Sorry No Records found


What are the side effects of WYMZYA Fe?

Sorry No records found


What should I look out for while using WYMZYA Fe?

Do not prescribe WYMZYA Fe to women who are known to have the following conditions:

■ Women over age 35 with any migraine headaches

ID707

WARNING: CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive (COC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, COCs are contraindicated in women who are over 35 years of age and smoke .


What might happen if I take too much WYMZYA Fe?

There have been no reports of serious ill effects from overdosage of oral contraceptives, including ingestion by children. Overdosage may cause withdrawal bleeding in females and nausea.


How should I store and handle WYMZYA Fe?

Store at 20° to 25°C (68° to 77°F); see USP controlled room temperature. Protect from light. Do not freeze.Venlafaxine Tablets, USP are available containing 25 mg, 37.5 mg, 50 mg, 75 mg or 100 mg of venlafaxine. 25 mg, peach colored, round shape, flat, beveled edge, uncoated tablets debossed with ‘175’ on one side and breakline on other side. NDC 62332-008-30 bottle of 30 tablets. NDC 62332-008-31 bottle of 100 tablets. NDC 62332-008-91 bottle of 1000 tablets. 37.5 mg, peach colored, round shape, flat, beveled edge, uncoated tablets debossed with ‘176’ on one side and breakline on other side. NDC 62332-009-30 bottle of 30 tablets. NDC 62332-009-31 bottle of 100 tablets. NDC 62332-009-91 bottle of 1000 tablets. 50 mg, peach colored, round shape, flat, beveled edge, uncoated tablets debossed with ‘L177’ on one side and breakline on other side. NDC 62332-010-30 bottle of 30 tablets. NDC 62332-010-31 bottle of 100 tablets. NDC 62332-010-91 bottle of 1000 tablets. 75 mg, peach colored, round shape, flat, beveled edge, uncoated tablets debossed with ‘L178’ on one side and breakline on other side. NDC 62332-011-30 bottle of 30 tablets. NDC 62332-011-31 bottle of 100 tablets. NDC 62332-011-91 bottle of 1000 tablets. 100 mg, peach colored, round shape, flat, beveled edge, uncoated tablets debossed with ‘L179’ on one side and breakline on other side. NDC 62332-012-30 bottle of 30 tablets. NDC 62332-012-31 bottle of 100 tablets. NDC 62332-012-91 bottle of 1000 tablets. Medication Guide available at or call 1-866 210 9797. Manufactured by: (Formulation Division), Panelav 389350, Gujarat, India Manufactured for: 750 Route 202, Bridgewater, NJ 08807 USA Revised: 03/2017


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

COCs lower the risk of becoming pregnant primarily by suppressing ovulation. Other possible mechanisms may include cervical mucus changes that inhibit sperm penetration and endometrial changes that reduce the likelihood of implantation.

Non-Clinical Toxicology
Do not prescribe WYMZYA Fe to women who are known to have the following conditions:

■ Women over age 35 with any migraine headaches

ID707

WARNING: CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive (COC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, COCs are contraindicated in women who are over 35 years of age and smoke .

Use of COCs also increases the risk of arterial thromboses such as strokes and myocardial infarctions, especially in women with other risk factors for these events. COCs have been shown to increase both the relative and attributable risks of cerebrovascular events (thrombotic and hemorrhagic strokes). The risk increases with age, particularly in women over 35 years of age who smoke.

The following serious adverse reactions with the use of COCs are discussed elsewhere in the labeling:

The following adverse reactions are commonly reported by COC users. Because these reactions are voluntarily reported by from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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