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Xepi

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Overview

What is Xepi?

XEPI contains ozenoxacin, a quinolone antimicrobial. It is intended for topical use only.

The chemical name of ozenoxacin is 1-Cyclopropyl-8-methyl-7-(5-methyl-6-methylamino-pyridin-3-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid. Ozenoxacin, a white to pale-yellow crystalline solid, has a molecular formula of CHNO, and a molecular weight of 363.41. The chemical structure is:

Each gram of cream contains 10 mg of ozenoxacin (1% w/w) and the following inactive ingredients: benzoic acid, octyldodecanol, peglicol 5 oleate, pegoxol 7 stearate, propylene glycol, purified water, stearyl alcohol.



What does Xepi look like?



What are the available doses of Xepi?

Cream: Each gram contains 10 mg of ozenoxacin (1%) ().

What should I talk to my health care provider before I take Xepi?

How should I use Xepi?

XEPI™ is indicated for the topical treatment of impetigo due or in adult and pediatric patients 2 months of age and older .

Apply a thin layer of XEPI topically to the affected area twice daily for five days. Affected area may be up to 100 cm in adult and pediatric patients 12 years of age and older or 2% of the total body surface area and not exceeding 100 cm in pediatric patients less than 12 years of age.


What interacts with Xepi?

Sorry No Records found


What are the warnings of Xepi?

Sorry No Records found


What are the precautions of Xepi?

Sorry No Records found


What are the side effects of Xepi?

Sorry No records found


What should I look out for while using Xepi?

None.


What might happen if I take too much Xepi?

Any sign or symptom of overdose, either topically or by accidental ingestion, should be treated symptomatically. No specific antidote is known.


How should I store and handle Xepi?

Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].XEPI cream, 1% is a pale yellow cream supplied in 10-, 30-, and 45-gram tubes. Each gram of cream contains 10 mg of ozenoxacin.NDC 43538-320-10 (10-gram tube)NDC 43538-320-30 (30-gram tube)NDC 43538-320-45 (45-gram tube)XEPI cream, 1% is a pale yellow cream supplied in 10-, 30-, and 45-gram tubes. Each gram of cream contains 10 mg of ozenoxacin.NDC 43538-320-10 (10-gram tube)NDC 43538-320-30 (30-gram tube)NDC 43538-320-45 (45-gram tube)


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

XEPI is an antimicrobial drug .

Non-Clinical Toxicology
None.

The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, some azoles, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, quinolones and beta adrenergic blocking agents. When such drugs are administered to a patient receiving glipizide, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving glipizide, the patient should be observed closely for loss of control. binding studies with human serum proteins indicate that glipizide binds differently than tolbutamide and does not interact with salicylate or dicumarol. However, caution must be exercised in extrapolating these findings to the clinical situation and in the use of glipizide with these drugs.

Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving glipizide, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving glipizide, the patient should be observed closely for hypoglycemia.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known. The effect of concomitant administration of fluconazole and glipizide has been demonstrated in a placebo-controlled crossover study in normal volunteers. All subjects received glipizide alone and following treatment with 100 mg of fluconazole as a single daily oral dose for 7 days. The mean percentage increase in the glipizide AUC after fluconazole administration was 56.9% (range: 35 to 81).

In studies assessing the effect of colesevelam on the pharmacokinetics of glipizide ER in healthy volunteers, reductions in glipizide AUC and C of 12% and 13%, respectively were observed when colesevelam was coadministered with glipizide ER. When glipizide ER was administered 4 hours prior to colesevelam, there was no significant change in glipizide AUC or C, -4% and 0%, respectively. Therefore, glipizide should be administered at least 4 hours prior to colesevelam to ensure that colesevelam does not reduce the absorption of glipizide.

Potential for Microbial Overgrowth

The prolonged use of XEPI may result in overgrowth of nonsusceptible bacteria and fungi. If such infections occur during therapy, discontinue use and institute appropriate supportive measures.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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