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ketoconazole
Overview
What is Xolegel?
XOLEGEL contains the antifungal agent ketoconazole USP at 2% in a topical anhydrous gel vehicle for topical administration.
Chemically, ketoconazole is (±)-cis-1-Acetyl-4-[p-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, with the molecular formula CHClNO and a molecular weight of 531.43.
Each gram contains: 20 mg ketoconazole USP, dehydrated alcohol (34%), ascorbic acid, butylated hydroxytoluene, citric acid monohydrate, glycerin, hydroxypropyl cellulose, polyethylene glycol 400, PPG-15 stearyl ether, propylene glycol, FD&C yellow No. 6, and FD&C yellow No. 10.
XOLEGEL is a smooth, translucent to clear, amber gel.
What does Xolegel look like?
What are the available doses of Xolegel?
XOLEGEL is a translucent to clear amber colored gel containing 2% ketoconazole.
What should I talk to my health care provider before I take Xolegel?
How should I use Xolegel?
XOLEGEL is indicated for the topical treatment of seborrheic dermatitis in immunocompetent adults and children 12 years of age and older.
Safety and efficacy of XOLEGEL for treatment of fungal infections have not been established.
XOLEGEL is for topical use only, and not for oral, ophthalmic, or intravaginal use.
XOLEGEL should be applied once daily to the affected area for 2 weeks.
What interacts with Xolegel?
Sorry No Records found
What are the warnings of Xolegel?
Sorry No Records found
What are the precautions of Xolegel?
Sorry No Records found
What are the side effects of Xolegel?
Sorry No records found
What should I look out for while using Xolegel?
None.
What might happen if I take too much Xolegel?
XOLEGEL is intended for topical use only.
There has been no experience of overdose with XOLEGEL. No incidents of accidental ingestion have been reported. A health care provider or poison control center should be contacted in the event of accidental ingestion.
How should I store and handle Xolegel?
Store at 25°C (77°F); excursions permitted to 15° - 30°C (59° - 86°F).Contents are flammable.Keep out of reach of children.Store at 25°C (77°F); excursions permitted to 15° - 30°C (59° - 86°F).Contents are flammable.Keep out of reach of children.Store at 25°C (77°F); excursions permitted to 15° - 30°C (59° - 86°F).Contents are flammable.Keep out of reach of children.FUROSEMIDE TABLETS 40 mg are supplied as white, round, scored tablets, the 40 mg tablets are imprinted with "EP 117" on one side and "40" on the other.Note: Tested by USP Dissolution Test 2Store at 25° C (77° F); excursions permitted to 15 to 30° C (59 to 86° F). [See USP Controlled Room Temperature.]FUROSEMIDE TABLETS 40 mg are supplied as white, round, scored tablets, the 40 mg tablets are imprinted with "EP 117" on one side and "40" on the other.Note: Tested by USP Dissolution Test 2Store at 25° C (77° F); excursions permitted to 15 to 30° C (59 to 86° F). [See USP Controlled Room Temperature.]FUROSEMIDE TABLETS 40 mg are supplied as white, round, scored tablets, the 40 mg tablets are imprinted with "EP 117" on one side and "40" on the other.Note: Tested by USP Dissolution Test 2Store at 25° C (77° F); excursions permitted to 15 to 30° C (59 to 86° F). [See USP Controlled Room Temperature.]FUROSEMIDE TABLETS 40 mg are supplied as white, round, scored tablets, the 40 mg tablets are imprinted with "EP 117" on one side and "40" on the other.Note: Tested by USP Dissolution Test 2Store at 25° C (77° F); excursions permitted to 15 to 30° C (59 to 86° F). [See USP Controlled Room Temperature.]
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
The mechanism of action of ketoconazole in the treatment of seborrheic dermatitis is unknown.
Non-Clinical Toxicology
None.FUROSEMIDE TABLET may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function. Except in life-threatening situations, avoid this combination.
FUROSEMIDE TABLET should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity. Patients receiving high doses of salicylates concomitantly with FUROSEMIDE TABLET, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.
FUROSEMIDE TABLET has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine.
Lithium generally should not be given with diuretics because they reduce lithium's renal clearance and add a high risk of lithium toxicity.
FUROSEMIDE TABLET may add to or potentiate the therapeutic effect of other antihypertensive drugs. Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs.
FUROSEMIDE TABLET may decrease arterial responsiveness to norepinephrine. However, norepinephrine may still be used effectively.
Simultaneous administration of sucralfate and FUROSEMIDE TABLET may reduce the natriuretic and antihypertensive effects of FUROSEMIDE TABLET. Patients receiving both drugs should be observed closely to determine if the desired diuretic and/or antihypertensive effect of FUROSEMIDE TABLET is achieved. The intake of FUROSEMIDE TABLET and sucralfate should be separated by at least two hours.
One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiency. There are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when furosemide was used in conjunction with NSAIDs.
Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of FUROSEMIDE TABLET (furosemide) in some patients by inhibiting prostaglandin synthesis. Indomethacin may also affect plasma renin levels, aldosterone excretion, and renin profile evaluation. Patients receiving both indomethacin and FUROSEMIDE TABLET should be observed closely to determine if the desired diuretic and/or antihypertensive effect of FUROSEMIDE TABLET is achieved.
XOLEGEL is flammable. Avoid being near fire, flame, or smoking during and immediately following application of XOLEGEL.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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