Disclaimer:

Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.

Xolox

&times

Overview

What is Xolox?

DESCRIPTION

Oxycodone Hydrochloride, USP    10 mg*Acetaminophen, USP                      500 mg*10 mg oxycodone HCl is equivalent to 8.9637 mg of oxycodone.

XOLOX (oxycodone and acetaminophen tablets, USP) also contains the following inactive ingredients: croscarmellose sodium, crospovidone, microcrystalline cellulose, povidone, pregelatinized starch, silicon dioxide, and stearic acid.

Oxycodone, 14-hydroxydihydrocodeinone, is a semisynthetic opioid analgesic which occurs as a white, odorless, crystalline powder having a saline, bitter taste. The molecular formula for oxycodone hydrochloride is C18H21NO4•HCl and the molecular weight is 351.82. It is derived from the opium alkaloid thebaine, and may be represented by the following structural formula:

Acetaminophen, 4'-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic and antipyretic which occurs as a white, odorless, crystalline powder, possessing a slightly bitter taste. The molecular formula for acetaminophen is C8H9NO2 and the molecular weight is 151.16. It may be represented by the following structural formula:



What does Xolox look like?



What are the available doses of Xolox?

Sorry No records found.

What should I talk to my health care provider before I take Xolox?

Sorry No records found

How should I use Xolox?

INDICATIONS AND USAGE

Cessation of Therapy


What interacts with Xolox?

Sorry No Records found


What are the warnings of Xolox?

Sorry No Records found


What are the precautions of Xolox?

Sorry No Records found


What are the side effects of Xolox?

Sorry No records found


What should I look out for while using Xolox?

CONTRAINDICATIONS

Oxycodone is contraindicated in any situation where opioids are contraindicated including patients with significant respiratory depression (in unmonitored settings or the absence of resuscitative equipment) and patients with acute or severe bronchial asthma or hypercarbia. Oxycodone is contraindicated in the setting of suspected or known paralytic ileus.

WARNINGSMisuse, Abuse and Diversion of Opioids

Oxycodone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing XOLOX in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion. Concerns about misuse, addiction, and diversion should not prevent the proper management of pain.

Healthcare professionals should contact their State Professional Licensing Board or State Controlled Substances Authority for information on how to prevent and detect abuse or diversion of this product.

Administration of XOLOX should be closely monitored for the following potentially serious adverse reactions and complications: 

Respiratory Depression

In case of respiratory depression, a reversal agent such as naloxone hydrochloride may be utilized. 

Head Injury and Increased Intracranial Pressure

Hypotensive Effect

Hepatotoxicity


What might happen if I take too much Xolox?

OVERDOSAGESigns and Symptoms

Treatment


How should I store and handle Xolox?

Store at 25º C (77º F); excursions permitted to 15–30C (59–86F) .HOW SUPPLIEDStore at 20° to 25°C (68° to 77°F). [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).DEA Order Form Required.Manufactured for:WraSerPharmaceuticalsMadison, MS 39110Manufactured by:MIKART, INC.Atlanta, Georgia 30318Code 988C00                                                    Rev.08/08Repackaged by:Rebel Distributors CorpThousand Oaks, CA 91320HOW SUPPLIEDStore at 20° to 25°C (68° to 77°F). [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).DEA Order Form Required.Manufactured for:WraSerPharmaceuticalsMadison, MS 39110Manufactured by:MIKART, INC.Atlanta, Georgia 30318Code 988C00                                                    Rev.08/08Repackaged by:Rebel Distributors CorpThousand Oaks, CA 91320HOW SUPPLIEDStore at 20° to 25°C (68° to 77°F). [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).DEA Order Form Required.Manufactured for:WraSerPharmaceuticalsMadison, MS 39110Manufactured by:MIKART, INC.Atlanta, Georgia 30318Code 988C00                                                    Rev.08/08Repackaged by:Rebel Distributors CorpThousand Oaks, CA 91320HOW SUPPLIEDStore at 20° to 25°C (68° to 77°F). [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).DEA Order Form Required.Manufactured for:WraSerPharmaceuticalsMadison, MS 39110Manufactured by:MIKART, INC.Atlanta, Georgia 30318Code 988C00                                                    Rev.08/08Repackaged by:Rebel Distributors CorpThousand Oaks, CA 91320HOW SUPPLIEDStore at 20° to 25°C (68° to 77°F). [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).DEA Order Form Required.Manufactured for:WraSerPharmaceuticalsMadison, MS 39110Manufactured by:MIKART, INC.Atlanta, Georgia 30318Code 988C00                                                    Rev.08/08Repackaged by:Rebel Distributors CorpThousand Oaks, CA 91320HOW SUPPLIEDStore at 20° to 25°C (68° to 77°F). [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).DEA Order Form Required.Manufactured for:WraSerPharmaceuticalsMadison, MS 39110Manufactured by:MIKART, INC.Atlanta, Georgia 30318Code 988C00                                                    Rev.08/08Repackaged by:Rebel Distributors CorpThousand Oaks, CA 91320HOW SUPPLIEDStore at 20° to 25°C (68° to 77°F). [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).DEA Order Form Required.Manufactured for:WraSerPharmaceuticalsMadison, MS 39110Manufactured by:MIKART, INC.Atlanta, Georgia 30318Code 988C00                                                    Rev.08/08Repackaged by:Rebel Distributors CorpThousand Oaks, CA 91320HOW SUPPLIEDStore at 20° to 25°C (68° to 77°F). [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).DEA Order Form Required.Manufactured for:WraSerPharmaceuticalsMadison, MS 39110Manufactured by:MIKART, INC.Atlanta, Georgia 30318Code 988C00                                                    Rev.08/08Repackaged by:Rebel Distributors CorpThousand Oaks, CA 91320HOW SUPPLIEDStore at 20° to 25°C (68° to 77°F). [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).DEA Order Form Required.Manufactured for:WraSerPharmaceuticalsMadison, MS 39110Manufactured by:MIKART, INC.Atlanta, Georgia 30318Code 988C00                                                    Rev.08/08Repackaged by:Rebel Distributors CorpThousand Oaks, CA 91320HOW SUPPLIEDStore at 20° to 25°C (68° to 77°F). [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).DEA Order Form Required.Manufactured for:WraSerPharmaceuticalsMadison, MS 39110Manufactured by:MIKART, INC.Atlanta, Georgia 30318Code 988C00                                                    Rev.08/08Repackaged by:Rebel Distributors CorpThousand Oaks, CA 91320


&times

Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

CLINICAL PHARMACOLOGYCentral Nervous System

Acetaminophen is a non-opiate, non-salicylate analgesic and antipyretic. The site and mechanism for the analgesic effect of acetaminophen has not been determined. The antipyretic effect of acetaminophen is accomplished through the inhibition of endogenous pyrogen action on the hypothalamic heat-regulating centers. 

Gastrointestinal Tract and Other Smooth Muscle

Cardiovascular System

Pharmacokinetics

Absorption of acetaminophen is rapid and almost complete from the GI tract after oral administration. With overdosage, absorption is complete in 4 hours. Acetaminophen is relatively uniformly distributed throughout most body fluids. Binding of the drug to plasma proteins is variable; only 20% to 50% may be bound at the concentrations encountered during acute intoxication. 

Metabolism and Elimination

Acetaminophen is metabolized in the liver via cytochrome P450 microsomal enzyme. About 80-85% of the acetaminophen in the body is conjugated principally with glucuronic acid and to a lesser extent with sulfuric acid and cysteine. After hepatic conjugation, 90 to 100% of the drug is recovered in the urine within the first day.

About 4% of acetaminophen is metabolized via cytochrome P450 oxidase to a toxic metabolite which is further detoxified by conjugation with glutathione, present in a fixed amount. It is believed that the toxic metabolite NAPQI (N acetyl-p-benzoquinoneimine, N-acetylimidoquinone) is responsible for liver necrosis. High doses of acetaminophen may deplete the glutathione stores so that inactivation of the toxic metabolite is decreased. At high doses, the capacity of metabolic pathways for conjugation with glucuronic acid and sulfuric acid may be exceeded, resulting in increased metabolism of acetaminophen by alternate pathways.

Non-Clinical Toxicology
CONTRAINDICATIONS

Oxycodone is contraindicated in any situation where opioids are contraindicated including patients with significant respiratory depression (in unmonitored settings or the absence of resuscitative equipment) and patients with acute or severe bronchial asthma or hypercarbia. Oxycodone is contraindicated in the setting of suspected or known paralytic ileus.

WARNINGSMisuse, Abuse and Diversion of Opioids

Oxycodone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing XOLOX in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion. Concerns about misuse, addiction, and diversion should not prevent the proper management of pain.

Healthcare professionals should contact their State Professional Licensing Board or State Controlled Substances Authority for information on how to prevent and detect abuse or diversion of this product.

Administration of XOLOX should be closely monitored for the following potentially serious adverse reactions and complications: 

Respiratory Depression

In case of respiratory depression, a reversal agent such as naloxone hydrochloride may be utilized. 

Head Injury and Increased Intracranial Pressure

Hypotensive Effect

Hepatotoxicity

This drug may enhance the effects of other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants, causing increased CNS depression.

Hepatic Impairment

Renal Impairment

ADVERSE REACTIONS

The most frequently observed non-serious adverse reactions include lightheadedness, dizziness, drowsiness or sedation, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in nonambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down. Other adverse reactions include euphoria, dysphoria, constipation, and pruritus.

Hypersensitivity reactionsmay include: Skin eruptions, urticarial, erythematous skin reactions. Hematologic reactions may include: Thrombocytopenia, neutropenia, pancytopenia, hemolytic anemia. Rare cases of agranulocytosis has likewise been associated with acetaminophen use. In high doses, the most serious adverse effect is a dose-dependent, potentially fatal hepatic necrosis. Renal tubular necrosis and hypoglycemic coma also may occur.

Other adverse reactions obtained from postmarketing experiences with XOLOX are listed by organ system and in decreasing order of severity and/or frequency as follows: 

Body as a Whole

Cardiovascular

Central and Peripheral Nervous System

Fluid and Electrolyte

Gastrointestinal

Hepatic

Hearing and Vestibular

Hematologic

Hypersensitivity

Metabolic and Nutritional

Musculoskeletal

Ocular

Psychiatric

Respiratory System

Skin and Appendages

Urogenital

&times

Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

&times

Review

Rate this treatment and share your opinion


Helpful tips to write a good review:

  1. Only share your first hand experience as a consumer or a care giver.
  2. Describe your experience in the Comments area including the benefits, side effects and how it has worked for you. Do not provide personal information like email addresses or telephone numbers.
  3. Fill in the optional information to help other users benefit from your review.

Reason for Taking This Treatment

(required)

Click the stars to rate this treatment

This medication has worked for me.




This medication has been easy for me to use.




Overall, I have been satisfied with my experience.




Write a brief description of your experience with this treatment:

2000 characters remaining

Optional Information

Help others benefit from your review by filling in the information below.
I am a:
Gender:
&times

Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
&times

Tips

Tips

&times

Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).