Disclaimer:

Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.

Zosyn

×

Overview

What is Zosyn?

ZOSYN (piperacillin and tazobactam) for Injection and ZOSYN (piperacillin and tazobactam) Injection are injectable antibacterial combination products consisting of the semisynthetic antibacterial piperacillin sodium and the β-lactamase inhibitor tazobactam sodium for intravenous administration.

Piperacillin sodium is derived from D(-)-α-aminobenzyl-penicillin. The chemical name of piperacillin sodium is sodium (2,5,6)-6-[()-2-(4-ethyl-2,3-dioxo-1-piperazine-carboxamido)-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate. The chemical formula is CHNNaOS and the molecular weight is 539.5. The chemical structure of piperacillin sodium is:

Tazobactam sodium, a derivative of the penicillin nucleus, is a penicillanic acid sulfone. Its chemical name is sodium (235)-3-methyl-7-oxo-3-(1-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate-4,4-dioxide. The chemical formula is CHNNaOS and the molecular weight is 322.3. The chemical structure of tazobactam sodium is:

ZOSYN (piperacillin and tazobactam) for Injection, is a white to off-white sterile, cryodesiccated powder consisting of piperacillin and tazobactam as their sodium salts packaged in glass vials. The formulation also contains edetate disodium dihydrate (EDTA) and sodium citrate.

Each ZOSYN 2.25 g single dose vial contains an amount of drug sufficient for withdrawal of piperacillin sodium equivalent to 2 grams of piperacillin and tazobactam sodium equivalent to 0.25 g of tazobactam. The product also contains 0.5 mg of EDTA per vial.

Each ZOSYN 3.375 g single dose vial contains an amount of drug sufficient for withdrawal of piperacillin sodium equivalent to 3 grams of piperacillin and tazobactam sodium equivalent to 0.375 g of tazobactam. The product also contains 0.75 mg of EDTA per vial.

Each ZOSYN 4.5 g single dose vial contains an amount of drug sufficient for withdrawal of piperacillin sodium equivalent to 4 grams of piperacillin and tazobactam sodium equivalent to 0.5 g of tazobactam. The product also contains 1 mg of EDTA per vial.

Each Zosyn 40.5 g pharmacy bulk vial contains piperacillin sodium equivalent to 36 grams of piperacillin and tazobactam sodium equivalent to 4.5 g of tazobactam sufficient for delivery of multiple doses.

ZOSYN Injection in the GALAXY Container is a frozen iso-osmotic sterile non-pyrogenic premixed solution. The components and dosage formulations are given in the table below:

ZOSYN contains a total of 2.84 mEq (65 mg) of sodium (Na) per gram of piperacillin in the combination product.



What does Zosyn look like?



What are the available doses of Zosyn?

ZOSYN(piperacillin and tazobactam) for Injection is supplied as a white to off-white powder in vials of the following sizes:

Each ZOSYN 2.25 g vial provides piperacillin sodium equivalent to 2 grams of piperacillin and tazobactam sodium equivalent to 0.25 g of tazobactam.

Each ZOSYN 3.375 g vial provides piperacillin sodium equivalent to 3 grams of piperacillin and tazobactam sodium equivalent to 0.375 g of tazobactam.

Each ZOSYN 4.5 g vial provides piperacillin sodium equivalent to 4 grams of piperacillin and tazobactam sodium equivalent to 0.5 g of tazobactam.

Each ZOSYN 40.5 g pharmacy bulk vial contains piperacillin sodium equivalent to 36 grams of piperacillin and tazobactam sodium equivalent to 4.5 grams tazobactam.

ZOSYN(piperacillin and tazobactam) Injection is supplied in GALAXY Containers as a frozen, iso-osmotic, sterile, non-pyrogenic solution in single-dose plastic containers:

2.25 g (piperacillin sodium equivalent to 2 g piperacillin/tazobactam sodium equivalent to 0.25 g tazobactam) in 50 mL.

3.375 g (piperacillin sodium equivalent to 3 g piperacillin/tazobactam sodium equivalent to 0.375 g tazobactam) in 50 mL.

4.5 g (piperacillin sodium equivalent to 4 g piperacillin/tazobactam sodium equivalent to 0.5 g tazobactam) in 100 mL.

What should I talk to my health care provider before I take Zosyn?

Dosage in patients with renal impairment (≤40 mL/min of CRCL) should be reduced to the degree of actual renal function impairment. (,)

How should I use Zosyn?

ZOSYN is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a β-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below.

ZOSYN should be administered by intravenous infusion over 30 minutes.


What interacts with Zosyn?

Sorry No Records found


What are the warnings of Zosyn?

Sorry No Records found


What are the precautions of Zosyn?

Sorry No Records found


What are the side effects of Zosyn?

Sorry No records found


What should I look out for while using Zosyn?

ZOSYN is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or β-lactamase inhibitors.


What might happen if I take too much Zosyn?

There have been postmarketing reports of overdose with piperacillin/tazobactam. The majority of those events experienced, including nausea, vomiting, and diarrhea, have also been reported with the usual recommended dosages. Patients may experience neuromuscular excitability or convulsions if higher than recommended doses are given intravenously (particularly in the presence of renal failure) [].

Treatment should be supportive and symptomatic according the patient's clinical presentation. Excessive serum concentrations of either piperacillin or tazobactam may be reduced by hemodialysis. Following a single 3.375 g dose of piperacillin/tazobactam, the percentage of the piperacillin and tazobactam dose removed by hemodialysis was approximately 31% and 39%, respectively [].


How should I store and handle Zosyn?

STORE Tamsulosin hydrochloride capsules USP, 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with light green cap and yellow body imprinted with “TML 0.4” on cap and body. Available:Overbagged with 10 capsules per bag, NDC 55154-7649-0Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F)Keep tamsulosin hydrochloride capsules, USP and all medicines out of reach of children.Tamsulosin hydrochloride capsules USP, 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with light green cap and yellow body imprinted with “TML 0.4” on cap and body. Available:Overbagged with 10 capsules per bag, NDC 55154-7649-0Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F)Keep tamsulosin hydrochloride capsules, USP and all medicines out of reach of children.Tamsulosin hydrochloride capsules USP, 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with light green cap and yellow body imprinted with “TML 0.4” on cap and body. Available:Overbagged with 10 capsules per bag, NDC 55154-7649-0Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F)Keep tamsulosin hydrochloride capsules, USP and all medicines out of reach of children.Tamsulosin hydrochloride capsules USP, 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with light green cap and yellow body imprinted with “TML 0.4” on cap and body. Available:Overbagged with 10 capsules per bag, NDC 55154-7649-0Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F)Keep tamsulosin hydrochloride capsules, USP and all medicines out of reach of children.Tamsulosin hydrochloride capsules USP, 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with light green cap and yellow body imprinted with “TML 0.4” on cap and body. Available:Overbagged with 10 capsules per bag, NDC 55154-7649-0Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F)Keep tamsulosin hydrochloride capsules, USP and all medicines out of reach of children.