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Zosyn

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Overview

What is Zosyn?

ZOSYN (piperacillin and tazobactam) for Injection and ZOSYN (piperacillin and tazobactam) Injection are injectable antibacterial combination products consisting of the semisynthetic antibacterial piperacillin sodium and the β-lactamase inhibitor tazobactam sodium for intravenous administration.

Piperacillin sodium is derived from D(-)-α-aminobenzyl-penicillin. The chemical name of piperacillin sodium is sodium (2,5,6)-6-[()-2-(4-ethyl-2,3-dioxo-1-piperazine-carboxamido)-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate. The chemical formula is CHNNaOS and the molecular weight is 539.5. The chemical structure of piperacillin sodium is:

Tazobactam sodium, a derivative of the penicillin nucleus, is a penicillanic acid sulfone. Its chemical name is sodium (235)-3-methyl-7-oxo-3-(1-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate-4,4-dioxide. The chemical formula is CHNNaOS and the molecular weight is 322.3. The chemical structure of tazobactam sodium is:

ZOSYN (piperacillin and tazobactam) for Injection, is a white to off-white sterile, cryodesiccated powder consisting of piperacillin and tazobactam as their sodium salts packaged in glass vials. The formulation also contains edetate disodium dihydrate (EDTA) and sodium citrate.

Each ZOSYN 2.25 g single dose vial contains an amount of drug sufficient for withdrawal of piperacillin sodium equivalent to 2 grams of piperacillin and tazobactam sodium equivalent to 0.25 g of tazobactam. The product also contains 0.5 mg of EDTA per vial.

Each ZOSYN 3.375 g single dose vial contains an amount of drug sufficient for withdrawal of piperacillin sodium equivalent to 3 grams of piperacillin and tazobactam sodium equivalent to 0.375 g of tazobactam. The product also contains 0.75 mg of EDTA per vial.

Each ZOSYN 4.5 g single dose vial contains an amount of drug sufficient for withdrawal of piperacillin sodium equivalent to 4 grams of piperacillin and tazobactam sodium equivalent to 0.5 g of tazobactam. The product also contains 1 mg of EDTA per vial.

Each Zosyn 40.5 g pharmacy bulk vial contains piperacillin sodium equivalent to 36 grams of piperacillin and tazobactam sodium equivalent to 4.5 g of tazobactam sufficient for delivery of multiple doses.

ZOSYN Injection in the GALAXY Container is a frozen iso-osmotic sterile non-pyrogenic premixed solution. The components and dosage formulations are given in the table below:

ZOSYN contains a total of 2.84 mEq (65 mg) of sodium (Na) per gram of piperacillin in the combination product.



What does Zosyn look like?



What are the available doses of Zosyn?

ZOSYN(piperacillin and tazobactam) for Injection is supplied as a white to off-white powder in vials of the following sizes:

Each ZOSYN 2.25 g vial provides piperacillin sodium equivalent to 2 grams of piperacillin and tazobactam sodium equivalent to 0.25 g of tazobactam.

Each ZOSYN 3.375 g vial provides piperacillin sodium equivalent to 3 grams of piperacillin and tazobactam sodium equivalent to 0.375 g of tazobactam.

Each ZOSYN 4.5 g vial provides piperacillin sodium equivalent to 4 grams of piperacillin and tazobactam sodium equivalent to 0.5 g of tazobactam.

Each ZOSYN 40.5 g pharmacy bulk vial contains piperacillin sodium equivalent to 36 grams of piperacillin and tazobactam sodium equivalent to 4.5 grams tazobactam.

ZOSYN(piperacillin and tazobactam) Injection is supplied in GALAXY Containers as a frozen, iso-osmotic, sterile, non-pyrogenic solution in single-dose plastic containers:

2.25 g (piperacillin sodium equivalent to 2 g piperacillin/tazobactam sodium equivalent to 0.25 g tazobactam) in 50 mL.

3.375 g (piperacillin sodium equivalent to 3 g piperacillin/tazobactam sodium equivalent to 0.375 g tazobactam) in 50 mL.

4.5 g (piperacillin sodium equivalent to 4 g piperacillin/tazobactam sodium equivalent to 0.5 g tazobactam) in 100 mL.

What should I talk to my health care provider before I take Zosyn?

Dosage in patients with renal impairment (≤40 mL/min of CRCL) should be reduced to the degree of actual renal function impairment. (,)

How should I use Zosyn?

ZOSYN is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a β-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below.

ZOSYN should be administered by intravenous infusion over 30 minutes.


What interacts with Zosyn?

Sorry No Records found


What are the warnings of Zosyn?

Sorry No Records found


What are the precautions of Zosyn?

Sorry No Records found


What are the side effects of Zosyn?

Sorry No records found


What should I look out for while using Zosyn?

ZOSYN is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or β-lactamase inhibitors.


What might happen if I take too much Zosyn?

There have been postmarketing reports of overdose with piperacillin/tazobactam. The majority of those events experienced, including nausea, vomiting, and diarrhea, have also been reported with the usual recommended dosages. Patients may experience neuromuscular excitability or convulsions if higher than recommended doses are given intravenously (particularly in the presence of renal failure) [].

Treatment should be supportive and symptomatic according the patient's clinical presentation. Excessive serum concentrations of either piperacillin or tazobactam may be reduced by hemodialysis. Following a single 3.375 g dose of piperacillin/tazobactam, the percentage of the piperacillin and tazobactam dose removed by hemodialysis was approximately 31% and 39%, respectively [].


How should I store and handle Zosyn?

STORE Tamsulosin hydrochloride capsules USP, 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with light green cap and yellow body imprinted with “TML 0.4” on cap and body. Available:Overbagged with 10 capsules per bag, NDC 55154-7649-0Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F)Keep tamsulosin hydrochloride capsules, USP and all medicines out of reach of children.Tamsulosin hydrochloride capsules USP, 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with light green cap and yellow body imprinted with “TML 0.4” on cap and body. Available:Overbagged with 10 capsules per bag, NDC 55154-7649-0Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F)Keep tamsulosin hydrochloride capsules, USP and all medicines out of reach of children.Tamsulosin hydrochloride capsules USP, 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with light green cap and yellow body imprinted with “TML 0.4” on cap and body. Available:Overbagged with 10 capsules per bag, NDC 55154-7649-0Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F)Keep tamsulosin hydrochloride capsules, USP and all medicines out of reach of children.Tamsulosin hydrochloride capsules USP, 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with light green cap and yellow body imprinted with “TML 0.4” on cap and body. Available:Overbagged with 10 capsules per bag, NDC 55154-7649-0Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F)Keep tamsulosin hydrochloride capsules, USP and all medicines out of reach of children.Tamsulosin hydrochloride capsules USP, 0.4 mg are supplied in high density polyethylene bottles containing hard gelatin capsules with light green cap and yellow body imprinted with “TML 0.4” on cap and body. Available:Overbagged with 10 capsules per bag, NDC 55154-7649-0Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F)Keep tamsulosin hydrochloride capsules, USP and all medicines out of reach of children.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

ZOSYN is an antibacterial drug [].

Non-Clinical Toxicology
ZOSYN is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or β-lactamase inhibitors.

Careful observation is required when amantadine is administered concurrently with central nervous system stimulants. Agents with anticholinergic properties may potentiate the anticholinergic-like side effects of amantadine.

Coadministration of thioridazine has been reported to worsen the tremor in elderly patients with Parkinson’s disease, however, it is not known if other phenothiazines produce a similar response. Coadministration of triamterene and hydrochlorothiazide capsules resulted in a higher plasma amantadine concentration in a 61-year-old man receiving amantadine (hydrochloride capsules) 100 mg t.i.d. for Parkinson’s disease. It is not known which of the components of triamterene and hydrochlorothiazide capsules contributed to the observation or if related drugs produce a similar response.

Coadministration of quinine or quinidine with amantadine was shown to reduce the renal clearance of amantadine by about 30%.

The concurrent use of amantadine with live attenuated influenza vaccine (LAIV) intranasal has not been evaluated. However, because of the potential for interference between these products, LAIV should not be administered within 2 weeks before or 48 hours after administration of amantadine, unless medically indicated. The concern about possible interference arises from the potential for antiviral drugs to inhibit replication of live vaccine virus. Trivalent inactivated influenza vaccine can be administered at any time relative to use of amantadine.

Serious and occasionally fatal hypersensitivity (anaphylactic/anaphylactoid) reactions (including shock) have been reported in patients receiving therapy with ZOSYN. These reactions are more likely to occur in individuals with a history of penicillin, cephalosporin, or carbapenem hypersensitivity or a history of sensitivity to multiple allergens. Before initiating therapy with ZOSYN, careful inquiry should be made concerning previous hypersensitivity reactions. If an allergic reaction occurs, ZOSYN should be discontinued and appropriate therapy instituted.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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