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Pitavastatin Magnesium

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Overview

What is ZYPITAMAG?

ZYPITAMAG (pitavastatin) is an inhibitor of HMG-CoA reductase. It is a synthetic lipid-lowering agent for oral administration.

The chemical name for pitavastatin is (3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinoline-3-yl]3,5-dihydroxy-6(E)-heptanoic acid hemi magnesium. The structural formula is:

The molecular formula for pitavastatin is CHMgFNO and the molecular weight is 865.21. Pitavastatin is a white to off-white powder. It is freely soluble in acetone, ethyl acetate; soluble in dimethylsulfoxide and insoluble in dichloromethane and isopropyl alcohol. Pitavastatin is hygroscopic and slightly unstable in light.

Each film-coated tablet of ZYPITAMAG contains 1.026 mg, 2.053 mg, or 4.106 mg of pitavastatin magnesium, which is equivalent to 1 mg, 2 mg, or 4 mg, respectively of free base and the following inactive ingredients: calcium carbonate, crospovidone, hypromellose, lactose monohydrate, magnesium stearate and sodium carbonate anhydrous and film-coating containing the following inactive ingredients: hypromellose, polyethylene glycol, talc and titanium dioxide.



What does ZYPITAMAG look like?



What are the available doses of ZYPITAMAG?

What should I talk to my health care provider before I take ZYPITAMAG?

How should I use ZYPITAMAG?

Drug therapy should be one component of multiple-risk-factor intervention in individuals who require modifications of their lipid profile. Lipid-altering agents should be used in addition to a diet restricted in saturated fat and cholesterol only when the response to diet and other nonpharmacological measures has been inadequate.

The dose range for ZYPITAMAG is 1 mg to 4 mg orally once daily at any time of the day with or without food. The recommended starting dose is 2 mg and the maximum dose is 4 mg. The starting dose and maintenance doses of ZYPITAMAG should be individualized according to patient characteristics, such as goal of therapy and response.

After initiation or upon titration of ZYPITAMAG, lipid levels should be analyzed after 4 weeks and the dosage adjusted accordingly.


What interacts with ZYPITAMAG?

Sorry No Records found


What are the warnings of ZYPITAMAG?

Sorry No Records found


What are the precautions of ZYPITAMAG?

Sorry No Records found


What are the side effects of ZYPITAMAG?

Sorry No records found


What should I look out for while using ZYPITAMAG?

The use of ZYPITAMAG is contraindicated in the following conditions:


What might happen if I take too much ZYPITAMAG?

There is no known specific treatment in the event of overdose of pitavastatin. In the event of overdose, the patient should be treated symptomatically and supportive measures instituted as required. Hemodialysis is unlikely to be of benefit due to high protein binding ratio of pitavastatin.


How should I store and handle ZYPITAMAG?

ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.ZYPITAMAG (pitavastatin) Tablets, 1 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "876" on one side and plain on the other side and are supplied as follows:NDC 25208-200-13 in bottle of 30 tablets with child-resistant closureNDC 25208-200-09 in bottle of 90 tablets with child-resistant closureNDC 25208-200-14 in bottle of 100 tabletsNDC 25208-200-15 in bottle of 500 tabletsNDC 25208-200-11 in bottle of 1000 tabletsNDC 25208-200-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 2 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "877" on one side and plain on the other side and are supplied as follows:NDC 25208-201-13 in bottle of 30 tablets with child-resistant closureNDC 25208-201-09 in bottle of 90 tablets with child-resistant closureNDC 25208-201-14 in bottle of 100 tabletsNDC 25208-201-15 in bottle of 500 tabletsNDC 25208-201-11 in bottle of 1000 tabletsNDC 25208-201-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsZYPITAMAG (pitavastatin) Tablets, 4 mg are white to off-white, beveled-edge, round-shaped tablets debossed with "878" on one side and plain on the other side and are supplied as follows:NDC 25208-202-13 in bottle of 30 tablets with child-resistant closureNDC 25208-202-09 in bottle of 90 tablets with child-resistant closureNDC 25208-202-14 in bottle of 100 tabletsNDC 25208-202-15 in bottle of 500 tabletsNDC 25208-202-11 in bottle of 1000 tabletsNDC 25208-202-12 in unit-dose blister cartons of 100 (10 x 10) unit-dose tabletsStorageStore at 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature].Protect from moisture and light.


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Pitavastatin competitively inhibits HMG-CoA reductase, which is a rate-determining enzyme involved with biosynthesis of cholesterol, in a manner of competition with the substrate so that it inhibits cholesterol synthesis in the liver. As a result, the expression of LDL-receptors followed by the uptake of LDL from blood to liver is accelerated and then the plasma TC decreases. Further, the sustained inhibition of cholesterol synthesis in the liver decreases levels of very low density lipoproteins.

Non-Clinical Toxicology
The use of ZYPITAMAG is contraindicated in the following conditions:

In vitro

In an interaction study in healthy volunteers, entacapone did not significantly change the plasma levels of S-warfarin while the AUC for R-warfarin increased on average by 18% [Cl90 11% to 26%], and the INR values increased on average by 13% [Cl90 6% to 19%]. Nevertheless, cases of significantly increased INR in patients concomitantly using warfarin have been reported during the postapproval use of Comtan. Therefore, monitoring of INR is recommended when entacapone treatment is initiated or when the dose is increased for patients receiving warfarin.

Cases of myopathy and rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with HMG-CoA reductase inhibitors, including pitavastatin.

ZYPITAMAG should be prescribed with caution in patients with predisposing factors for myopathy. These factors include advanced age (≥ 65 years), renal impairment, and inadequately treated hypothyroidism. The risk of myopathy may also be increased with concurrent administration of fibrates or lipid-modifying doses of niacin. ZYPITAMAG should be administered with caution in patients with impaired renal function, in elderly patients, or when used concomitantly with fibrates or lipid-modifying doses of niacin

Cases of myopathy, including rhabdomyolysis, have been reported with HMG-CoA reductase inhibitors coadministered with colchicine, and caution should be exercised when prescribing ZYPITAMAG with colchicine [].

There have been rare reports of immune-mediated necrotizing myopathy (IMNM), an autoimmune myopathy, associated with statin use. IMNM is characterized by: proximal muscle weakness and elevated serum creatine kinase, which persist despite discontinuation of statin treatment; muscle biopsy showing necrotizing myopathy without significant inflammation; improvement with immunosuppressive agents.

ZYPITAMAG therapy should be discontinued if markedly elevated creatine kinase (CK) levels occur or myopathy is diagnosed or suspected. ZYPITAMAG therapy should also be temporarily withheld in any patient with an acute, serious condition suggestive of myopathy or predisposing to the development of renal failure secondary to rhabdomyolysis (e.g., sepsis, hypotension, dehydration, major surgery, trauma, severe metabolic, endocrine, and electrolyte disorders, or uncontrolled seizures). All patients should be advised to promptly report unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever or if muscle signs and symptoms persist after discontinuing ZYPITAMAG.

The following serious adverse reactions are discussed in greater detail in other sections of the label:

Of 4,798 patients enrolled in 10 controlled clinical studies and 4 subsequent open-label extension studies, 3,291 patients were administered pitavastatin 1 mg to 4 mg daily. The mean continuous exposure of pitavastatin (1 mg to 4 mg) was 36.7 weeks (median 51.1 weeks). The mean age of the patients was 60.9 years (range; 18 years to 89 years) and the gender distribution was 48% males and 52% females. Approximately 93% of the patients were Caucasian, 7% were Asian/Indian, 0.2% were African American and 0.3% were Hispanic and other.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).