AKYNZEO (300 mg netupitant/0.5 mg palonosetron) is an oral fixed combination product of netupitant, a substance P/neurokinin 1 (NK) receptor antagonist, and palonosetron hydrochloride, a serotonin-3 (5-HT) receptor antagonist. Both netupitant and palonosetron hydrochloride are anti-nausea and anti-emetic agents. Netupitant… Continue Reading
DUTOPROL™ (metoprolol succinate extended release/hydrochlorothiazide) combines a beta-selective (cardioselective) adrenoceptor blocking agent and a diuretic, hydrochlorothiazide. Metoprolol succinate is chemically described as (±)1-(isopropylamino)-3-[p-(2-methoxyethyl) phenoxy]-2-propanol succinate (2:1) (salt). Its structural formula is: Metoprolol succinate is a white crystalline powder with a… Continue Reading
ACTIMMUNE (Interferon gamma-1b), an interferon gamma, is a single-chain polypeptide containing 140 amino acids. Production of ACTIMMUNE is achieved by fermentation of a genetically engineered bacterium containing the DNA which encodes for the recombinant protein. Purification of the product is… Continue Reading
Hydrocodone Bitartrate and Homatropine Methylbromide Oral Solution contains hydrocodone (dihydrocodeinone) bitartrate, USP, a semisynthetic centrally-acting opioid antitussive. Homatropine methylbromide, USP is included in a subtherapeutic amount to discourage deliberate overdosage. Each teaspoonful (5 mL) contains: Hydrocodone Bitartrate, USP …………………… 5… Continue Reading
Sumatriptan tablets USP contain sumatriptan (as the succinate), a selective 5-hydroxytryptamine receptor subtype agonist. Sumatriptan succinate USP is chemically designated as 3-[2- (dimethylamino) ethyl]-N-methyl-indole-5-methanesulfonamide succinate (1:1), and it has the following structure: The molecular formula is C H N O… Continue Reading
Chemical Characteristics The active ingredient in Lymphoseek, a radioactive diagnostic agent, is technetium Tc 99m tilmanocept. Technetium Tc 99m binds to the diethylenetriaminepentaacetic acid (DTPA) moieties of the tilmanocept molecule. Lymphoseek (technetium Tc 99m tilmanocept) injection is supplied as a… Continue Reading
The active ingredient in esomeprazole sodium for injection is ()-5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1 -benzimidazole sodium, a proton pump inhibitor that inhibits gastric acid secretion. Esomeprazole is the S-isomer of omeprazole, which is a mixture of the S- and R- isomers. Its molecular formula… Continue Reading
FABIOR (tazarotene) Foam, 0.1% contains the compound tazarotene, a member of the acetylenic class of retinoids. It is for topical use only. Chemically, tazarotene is ethyl 6-[(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinate. The structural formula is represented below: Molecular Formula: CHNOS Molecular Weight: 351.46 Tazarotene… Continue Reading
Zometa contains zoledronic acid, a bisphosphonic acid which is an inhibitor of osteoclastic bone resorption. Zoledronic acid is designated chemically as (1-Hydroxy-2-imidazol-1-yl-phosphonoethyl) phosphonic acid monohydrate and its structural formula is: Zoledronic acid is a white crystalline powder. Its molecular formula is CHNOP•HO and… Continue Reading
