Disclaimer:

Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.

PRAVACHOL

×

Overview

What is PRAVACHOL?

PRAVACHOL (pravastatin sodium) is one of a class of lipid-lowering compounds, the statins, which reduce cholesterol biosynthesis. These agents are competitive inhibitors of HMG-CoA reductase, the enzyme catalyzing the early rate-limiting step in cholesterol biosynthesis, conversion of HMG-CoA to mevalonate.

Pravastatin sodium is designated chemically as 1-Naphthalene-heptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, monosodium salt, [1S-[1α(βS*,δS*),2α,6α,8β(R*),8aα]]-.

Structural formula:

Pravastatin sodium is an odorless, white to off-white, fine or crystalline powder. It is a relatively polar hydrophilic compound with a partition coefficient (octanol/water) of 0.59 at a pH of 7.0. It is soluble in methanol and water (>300 mg/mL), slightly soluble in isopropanol, and practically insoluble in acetone, acetonitrile, chloroform, and ether.

PRAVACHOL is available for oral administration as 20 mg, 40 mg, and 80 mg tablets. Inactive ingredients include: croscarmellose sodium, lactose, magnesium oxide, magnesium stearate, microcrystalline cellulose, and povidone. The 20 mg and 80 mg tablets also contain Yellow Ferric Oxide and the 40 mg tablet also contains Green Lake Blend (mixture of D&C Yellow No. 10-Aluminum Lake and FD&C Blue No. 1-Aluminum Lake).



What does PRAVACHOL look like?



What are the available doses of PRAVACHOL?

PRAVACHOL

Tablets

20 mg tablets:

40 mg tablets:

80 mg tablets:

What should I talk to my health care provider before I take PRAVACHOL?

How should I use PRAVACHOL?

Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. Drug therapy is indicated as an adjunct to diet when the response to a diet restricted in saturated fat and cholesterol and other nonpharmacologic measures alone has been inadequate.

The patient should be placed on a standard cholesterol-lowering diet before receiving PRAVACHOL and should continue on this diet during treatment with PRAVACHOL [see NCEP Treatment Guidelines for details on dietary therapy].


What interacts with PRAVACHOL?

Sorry No Records found


What are the warnings of PRAVACHOL?

Sorry No Records found


What are the precautions of PRAVACHOL?

Sorry No Records found


What are the side effects of PRAVACHOL?

Sorry No records found


What should I look out for while using PRAVACHOL?

•

•

•

•


What might happen if I take too much PRAVACHOL?

To date, there has been limited experience with overdosage of pravastatin. If an overdose occurs, it should be treated symptomatically with laboratory monitoring and supportive measures should be instituted as required.


How should I store and handle PRAVACHOL?

Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Keep tightly closed (protect from moisture). Protect from light.Celecoxib capsules 50 mg are opaque white/opaque white hard gelatin capsules size “5” having imprinting “134” on body with red ink and “A” on cap with red ink filled with white to off-white colored granular powder.  NDC 62332-140-30    bottle of 30 capsulesNDC 62332-140-60    bottle of 60 capsulesNDC 62332-140-91    bottle of 1000 capsules NDC 62332-140-08    carton of 80 (10 x 8) unit-dose capsules NDC 62332-140-10    carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 100 mg are opaque white/opaque white hard gelatin capsules size “3” having imprinting “135” on body with blue ink and “A” on cap with blue ink filled with white to off-white colored granular powder.NDC 62332-141-30     bottle of 30 capsules NDC 62332-141-31     bottle of 100 capsules NDC 62332-141-91     bottle of 1000 capsules NDC 62332-141-08     carton of 80 (10 x 8) unit-dose capsules NDC 62332-141-10     carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 200 mg are opaque white/opaque white hard gelatin capsules size “1” having imprinting “136” on body with golden yellow ink and “A” on cap with golden yellow ink filled with white to off-white colored granular powder. NDC 62332-142-30      bottle of 30 capsules NDC 62332-142-31      bottle of 100 capsules NDC 62332-142-71      bottle of 500 capsules NDC 62332-142-91      bottle of 1000 capsules NDC 62332-142-08      carton of 80 (10 x 8) unit-dose capsules NDC 62332-142-10      carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 400 mg are opaque white/opaque white hard gelatin capsules size “00” having imprinting “137” on body with green ink and “A” on cap with green ink filled with white to off-white colored granular powder.NDC 62332-143-30       bottle of 30 capsules NDC 62332-143-60       bottle of 60 capsules NDC 62332-143-71       bottle of 500 capsules NDC 62332-143-10       carton of 100 (10 x 10) unit-dose capsules NDC 62332-143-14       carton of 126 (9 x 14) unit-dose capsules: Celecoxib capsules 50 mg are opaque white/opaque white hard gelatin capsules size “5” having imprinting “134” on body with red ink and “A” on cap with red ink filled with white to off-white colored granular powder.  NDC 62332-140-30    bottle of 30 capsulesNDC 62332-140-60    bottle of 60 capsulesNDC 62332-140-91    bottle of 1000 capsules NDC 62332-140-08    carton of 80 (10 x 8) unit-dose capsules NDC 62332-140-10    carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 100 mg are opaque white/opaque white hard gelatin capsules size “3” having imprinting “135” on body with blue ink and “A” on cap with blue ink filled with white to off-white colored granular powder.NDC 62332-141-30     bottle of 30 capsules NDC 62332-141-31     bottle of 100 capsules NDC 62332-141-91     bottle of 1000 capsules NDC 62332-141-08     carton of 80 (10 x 8) unit-dose capsules NDC 62332-141-10     carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 200 mg are opaque white/opaque white hard gelatin capsules size “1” having imprinting “136” on body with golden yellow ink and “A” on cap with golden yellow ink filled with white to off-white colored granular powder. NDC 62332-142-30      bottle of 30 capsules NDC 62332-142-31      bottle of 100 capsules NDC 62332-142-71      bottle of 500 capsules NDC 62332-142-91      bottle of 1000 capsules NDC 62332-142-08      carton of 80 (10 x 8) unit-dose capsules NDC 62332-142-10      carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 400 mg are opaque white/opaque white hard gelatin capsules size “00” having imprinting “137” on body with green ink and “A” on cap with green ink filled with white to off-white colored granular powder.NDC 62332-143-30       bottle of 30 capsules NDC 62332-143-60       bottle of 60 capsules NDC 62332-143-71       bottle of 500 capsules NDC 62332-143-10       carton of 100 (10 x 10) unit-dose capsules NDC 62332-143-14       carton of 126 (9 x 14) unit-dose capsules: Celecoxib capsules 50 mg are opaque white/opaque white hard gelatin capsules size “5” having imprinting “134” on body with red ink and “A” on cap with red ink filled with white to off-white colored granular powder.  NDC 62332-140-30    bottle of 30 capsulesNDC 62332-140-60    bottle of 60 capsulesNDC 62332-140-91    bottle of 1000 capsules NDC 62332-140-08    carton of 80 (10 x 8) unit-dose capsules NDC 62332-140-10    carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 100 mg are opaque white/opaque white hard gelatin capsules size “3” having imprinting “135” on body with blue ink and “A” on cap with blue ink filled with white to off-white colored granular powder.NDC 62332-141-30     bottle of 30 capsules NDC 62332-141-31     bottle of 100 capsules NDC 62332-141-91     bottle of 1000 capsules NDC 62332-141-08     carton of 80 (10 x 8) unit-dose capsules NDC 62332-141-10     carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 200 mg are opaque white/opaque white hard gelatin capsules size “1” having imprinting “136” on body with golden yellow ink and “A” on cap with golden yellow ink filled with white to off-white colored granular powder. NDC 62332-142-30      bottle of 30 capsules NDC 62332-142-31      bottle of 100 capsules NDC 62332-142-71      bottle of 500 capsules NDC 62332-142-91      bottle of 1000 capsules NDC 62332-142-08      carton of 80 (10 x 8) unit-dose capsules NDC 62332-142-10      carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 400 mg are opaque white/opaque white hard gelatin capsules size “00” having imprinting “137” on body with green ink and “A” on cap with green ink filled with white to off-white colored granular powder.NDC 62332-143-30       bottle of 30 capsules NDC 62332-143-60       bottle of 60 capsules NDC 62332-143-71       bottle of 500 capsules NDC 62332-143-10       carton of 100 (10 x 10) unit-dose capsules NDC 62332-143-14       carton of 126 (9 x 14) unit-dose capsules: Celecoxib capsules 50 mg are opaque white/opaque white hard gelatin capsules size “5” having imprinting “134” on body with red ink and “A” on cap with red ink filled with white to off-white colored granular powder.  NDC 62332-140-30    bottle of 30 capsulesNDC 62332-140-60    bottle of 60 capsulesNDC 62332-140-91    bottle of 1000 capsules NDC 62332-140-08    carton of 80 (10 x 8) unit-dose capsules NDC 62332-140-10    carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 100 mg are opaque white/opaque white hard gelatin capsules size “3” having imprinting “135” on body with blue ink and “A” on cap with blue ink filled with white to off-white colored granular powder.NDC 62332-141-30     bottle of 30 capsules NDC 62332-141-31     bottle of 100 capsules NDC 62332-141-91     bottle of 1000 capsules NDC 62332-141-08     carton of 80 (10 x 8) unit-dose capsules NDC 62332-141-10     carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 200 mg are opaque white/opaque white hard gelatin capsules size “1” having imprinting “136” on body with golden yellow ink and “A” on cap with golden yellow ink filled with white to off-white colored granular powder. NDC 62332-142-30      bottle of 30 capsules NDC 62332-142-31      bottle of 100 capsules NDC 62332-142-71      bottle of 500 capsules NDC 62332-142-91      bottle of 1000 capsules NDC 62332-142-08      carton of 80 (10 x 8) unit-dose capsules NDC 62332-142-10      carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 400 mg are opaque white/opaque white hard gelatin capsules size “00” having imprinting “137” on body with green ink and “A” on cap with green ink filled with white to off-white colored granular powder.NDC 62332-143-30       bottle of 30 capsules NDC 62332-143-60       bottle of 60 capsules NDC 62332-143-71       bottle of 500 capsules NDC 62332-143-10       carton of 100 (10 x 10) unit-dose capsules NDC 62332-143-14       carton of 126 (9 x 14) unit-dose capsules: Celecoxib capsules 50 mg are opaque white/opaque white hard gelatin capsules size “5” having imprinting “134” on body with red ink and “A” on cap with red ink filled with white to off-white colored granular powder.  NDC 62332-140-30    bottle of 30 capsulesNDC 62332-140-60    bottle of 60 capsulesNDC 62332-140-91    bottle of 1000 capsules NDC 62332-140-08    carton of 80 (10 x 8) unit-dose capsules NDC 62332-140-10    carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 100 mg are opaque white/opaque white hard gelatin capsules size “3” having imprinting “135” on body with blue ink and “A” on cap with blue ink filled with white to off-white colored granular powder.NDC 62332-141-30     bottle of 30 capsules NDC 62332-141-31     bottle of 100 capsules NDC 62332-141-91     bottle of 1000 capsules NDC 62332-141-08     carton of 80 (10 x 8) unit-dose capsules NDC 62332-141-10     carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 200 mg are opaque white/opaque white hard gelatin capsules size “1” having imprinting “136” on body with golden yellow ink and “A” on cap with golden yellow ink filled with white to off-white colored granular powder. NDC 62332-142-30      bottle of 30 capsules NDC 62332-142-31      bottle of 100 capsules NDC 62332-142-71      bottle of 500 capsules NDC 62332-142-91      bottle of 1000 capsules NDC 62332-142-08      carton of 80 (10 x 8) unit-dose capsules NDC 62332-142-10      carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 400 mg are opaque white/opaque white hard gelatin capsules size “00” having imprinting “137” on body with green ink and “A” on cap with green ink filled with white to off-white colored granular powder.NDC 62332-143-30       bottle of 30 capsules NDC 62332-143-60       bottle of 60 capsules NDC 62332-143-71       bottle of 500 capsules NDC 62332-143-10       carton of 100 (10 x 10) unit-dose capsules NDC 62332-143-14       carton of 126 (9 x 14) unit-dose capsules: Celecoxib capsules 50 mg are opaque white/opaque white hard gelatin capsules size “5” having imprinting “134” on body with red ink and “A” on cap with red ink filled with white to off-white colored granular powder.  NDC 62332-140-30    bottle of 30 capsulesNDC 62332-140-60    bottle of 60 capsulesNDC 62332-140-91    bottle of 1000 capsules NDC 62332-140-08    carton of 80 (10 x 8) unit-dose capsules NDC 62332-140-10    carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 100 mg are opaque white/opaque white hard gelatin capsules size “3” having imprinting “135” on body with blue ink and “A” on cap with blue ink filled with white to off-white colored granular powder.NDC 62332-141-30     bottle of 30 capsules NDC 62332-141-31     bottle of 100 capsules NDC 62332-141-91     bottle of 1000 capsules NDC 62332-141-08     carton of 80 (10 x 8) unit-dose capsules NDC 62332-141-10     carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 200 mg are opaque white/opaque white hard gelatin capsules size “1” having imprinting “136” on body with golden yellow ink and “A” on cap with golden yellow ink filled with white to off-white colored granular powder. NDC 62332-142-30      bottle of 30 capsules NDC 62332-142-31      bottle of 100 capsules NDC 62332-142-71      bottle of 500 capsules NDC 62332-142-91      bottle of 1000 capsules NDC 62332-142-08      carton of 80 (10 x 8) unit-dose capsules NDC 62332-142-10      carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 400 mg are opaque white/opaque white hard gelatin capsules size “00” having imprinting “137” on body with green ink and “A” on cap with green ink filled with white to off-white colored granular powder.NDC 62332-143-30       bottle of 30 capsules NDC 62332-143-60       bottle of 60 capsules NDC 62332-143-71       bottle of 500 capsules NDC 62332-143-10       carton of 100 (10 x 10) unit-dose capsules NDC 62332-143-14       carton of 126 (9 x 14) unit-dose capsules: Celecoxib capsules 50 mg are opaque white/opaque white hard gelatin capsules size “5” having imprinting “134” on body with red ink and “A” on cap with red ink filled with white to off-white colored granular powder.  NDC 62332-140-30    bottle of 30 capsulesNDC 62332-140-60    bottle of 60 capsulesNDC 62332-140-91    bottle of 1000 capsules NDC 62332-140-08    carton of 80 (10 x 8) unit-dose capsules NDC 62332-140-10    carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 100 mg are opaque white/opaque white hard gelatin capsules size “3” having imprinting “135” on body with blue ink and “A” on cap with blue ink filled with white to off-white colored granular powder.NDC 62332-141-30     bottle of 30 capsules NDC 62332-141-31     bottle of 100 capsules NDC 62332-141-91     bottle of 1000 capsules NDC 62332-141-08     carton of 80 (10 x 8) unit-dose capsules NDC 62332-141-10     carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 200 mg are opaque white/opaque white hard gelatin capsules size “1” having imprinting “136” on body with golden yellow ink and “A” on cap with golden yellow ink filled with white to off-white colored granular powder. NDC 62332-142-30      bottle of 30 capsules NDC 62332-142-31      bottle of 100 capsules NDC 62332-142-71      bottle of 500 capsules NDC 62332-142-91      bottle of 1000 capsules NDC 62332-142-08      carton of 80 (10 x 8) unit-dose capsules NDC 62332-142-10      carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 400 mg are opaque white/opaque white hard gelatin capsules size “00” having imprinting “137” on body with green ink and “A” on cap with green ink filled with white to off-white colored granular powder.NDC 62332-143-30       bottle of 30 capsules NDC 62332-143-60       bottle of 60 capsules NDC 62332-143-71       bottle of 500 capsules NDC 62332-143-10       carton of 100 (10 x 10) unit-dose capsules NDC 62332-143-14       carton of 126 (9 x 14) unit-dose capsules: Celecoxib capsules 50 mg are opaque white/opaque white hard gelatin capsules size “5” having imprinting “134” on body with red ink and “A” on cap with red ink filled with white to off-white colored granular powder.  NDC 62332-140-30    bottle of 30 capsulesNDC 62332-140-60    bottle of 60 capsulesNDC 62332-140-91    bottle of 1000 capsules NDC 62332-140-08    carton of 80 (10 x 8) unit-dose capsules NDC 62332-140-10    carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 100 mg are opaque white/opaque white hard gelatin capsules size “3” having imprinting “135” on body with blue ink and “A” on cap with blue ink filled with white to off-white colored granular powder.NDC 62332-141-30     bottle of 30 capsules NDC 62332-141-31     bottle of 100 capsules NDC 62332-141-91     bottle of 1000 capsules NDC 62332-141-08     carton of 80 (10 x 8) unit-dose capsules NDC 62332-141-10     carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 200 mg are opaque white/opaque white hard gelatin capsules size “1” having imprinting “136” on body with golden yellow ink and “A” on cap with golden yellow ink filled with white to off-white colored granular powder. NDC 62332-142-30      bottle of 30 capsules NDC 62332-142-31      bottle of 100 capsules NDC 62332-142-71      bottle of 500 capsules NDC 62332-142-91      bottle of 1000 capsules NDC 62332-142-08      carton of 80 (10 x 8) unit-dose capsules NDC 62332-142-10      carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 400 mg are opaque white/opaque white hard gelatin capsules size “00” having imprinting “137” on body with green ink and “A” on cap with green ink filled with white to off-white colored granular powder.NDC 62332-143-30       bottle of 30 capsules NDC 62332-143-60       bottle of 60 capsules NDC 62332-143-71       bottle of 500 capsules NDC 62332-143-10       carton of 100 (10 x 10) unit-dose capsules NDC 62332-143-14       carton of 126 (9 x 14) unit-dose capsules: Celecoxib capsules 50 mg are opaque white/opaque white hard gelatin capsules size “5” having imprinting “134” on body with red ink and “A” on cap with red ink filled with white to off-white colored granular powder.  NDC 62332-140-30    bottle of 30 capsulesNDC 62332-140-60    bottle of 60 capsulesNDC 62332-140-91    bottle of 1000 capsules NDC 62332-140-08    carton of 80 (10 x 8) unit-dose capsules NDC 62332-140-10    carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 100 mg are opaque white/opaque white hard gelatin capsules size “3” having imprinting “135” on body with blue ink and “A” on cap with blue ink filled with white to off-white colored granular powder.NDC 62332-141-30     bottle of 30 capsules NDC 62332-141-31     bottle of 100 capsules NDC 62332-141-91     bottle of 1000 capsules NDC 62332-141-08     carton of 80 (10 x 8) unit-dose capsules NDC 62332-141-10     carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 200 mg are opaque white/opaque white hard gelatin capsules size “1” having imprinting “136” on body with golden yellow ink and “A” on cap with golden yellow ink filled with white to off-white colored granular powder. NDC 62332-142-30      bottle of 30 capsules NDC 62332-142-31      bottle of 100 capsules NDC 62332-142-71      bottle of 500 capsules NDC 62332-142-91      bottle of 1000 capsules NDC 62332-142-08      carton of 80 (10 x 8) unit-dose capsules NDC 62332-142-10      carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 400 mg are opaque white/opaque white hard gelatin capsules size “00” having imprinting “137” on body with green ink and “A” on cap with green ink filled with white to off-white colored granular powder.NDC 62332-143-30       bottle of 30 capsules NDC 62332-143-60       bottle of 60 capsules NDC 62332-143-71       bottle of 500 capsules NDC 62332-143-10       carton of 100 (10 x 10) unit-dose capsules NDC 62332-143-14       carton of 126 (9 x 14) unit-dose capsules: Celecoxib capsules 50 mg are opaque white/opaque white hard gelatin capsules size “5” having imprinting “134” on body with red ink and “A” on cap with red ink filled with white to off-white colored granular powder.  NDC 62332-140-30    bottle of 30 capsulesNDC 62332-140-60    bottle of 60 capsulesNDC 62332-140-91    bottle of 1000 capsules NDC 62332-140-08    carton of 80 (10 x 8) unit-dose capsules NDC 62332-140-10    carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 100 mg are opaque white/opaque white hard gelatin capsules size “3” having imprinting “135” on body with blue ink and “A” on cap with blue ink filled with white to off-white colored granular powder.NDC 62332-141-30     bottle of 30 capsules NDC 62332-141-31     bottle of 100 capsules NDC 62332-141-91     bottle of 1000 capsules NDC 62332-141-08     carton of 80 (10 x 8) unit-dose capsules NDC 62332-141-10     carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 200 mg are opaque white/opaque white hard gelatin capsules size “1” having imprinting “136” on body with golden yellow ink and “A” on cap with golden yellow ink filled with white to off-white colored granular powder. NDC 62332-142-30      bottle of 30 capsules NDC 62332-142-31      bottle of 100 capsules NDC 62332-142-71      bottle of 500 capsules NDC 62332-142-91      bottle of 1000 capsules NDC 62332-142-08      carton of 80 (10 x 8) unit-dose capsules NDC 62332-142-10      carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 400 mg are opaque white/opaque white hard gelatin capsules size “00” having imprinting “137” on body with green ink and “A” on cap with green ink filled with white to off-white colored granular powder.NDC 62332-143-30       bottle of 30 capsules NDC 62332-143-60       bottle of 60 capsules NDC 62332-143-71       bottle of 500 capsules NDC 62332-143-10       carton of 100 (10 x 10) unit-dose capsules NDC 62332-143-14       carton of 126 (9 x 14) unit-dose capsules: Celecoxib capsules 50 mg are opaque white/opaque white hard gelatin capsules size “5” having imprinting “134” on body with red ink and “A” on cap with red ink filled with white to off-white colored granular powder.  NDC 62332-140-30    bottle of 30 capsulesNDC 62332-140-60    bottle of 60 capsulesNDC 62332-140-91    bottle of 1000 capsules NDC 62332-140-08    carton of 80 (10 x 8) unit-dose capsules NDC 62332-140-10    carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 100 mg are opaque white/opaque white hard gelatin capsules size “3” having imprinting “135” on body with blue ink and “A” on cap with blue ink filled with white to off-white colored granular powder.NDC 62332-141-30     bottle of 30 capsules NDC 62332-141-31     bottle of 100 capsules NDC 62332-141-91     bottle of 1000 capsules NDC 62332-141-08     carton of 80 (10 x 8) unit-dose capsules NDC 62332-141-10     carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 200 mg are opaque white/opaque white hard gelatin capsules size “1” having imprinting “136” on body with golden yellow ink and “A” on cap with golden yellow ink filled with white to off-white colored granular powder. NDC 62332-142-30      bottle of 30 capsules NDC 62332-142-31      bottle of 100 capsules NDC 62332-142-71      bottle of 500 capsules NDC 62332-142-91      bottle of 1000 capsules NDC 62332-142-08      carton of 80 (10 x 8) unit-dose capsules NDC 62332-142-10      carton of 100 (10 x 10) unit-dose capsulesCelecoxib capsules 400 mg are opaque white/opaque white hard gelatin capsules size “00” having imprinting “137” on body with green ink and “A” on cap with green ink filled with white to off-white colored granular powder.NDC 62332-143-30       bottle of 30 capsules NDC 62332-143-60       bottle of 60 capsules NDC 62332-143-71       bottle of 500 capsules NDC 62332-143-10       carton of 100 (10 x 10) unit-dose capsules NDC 62332-143-14       carton of 126 (9 x 14) unit-dose capsules:


×

Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early and rate limiting step in the biosynthetic pathway for cholesterol. In addition, pravastatin reduces VLDL and TG and increases HDL-C.

Non-Clinical Toxicology
•

•

•

•

Caution should be exercised when propranolol is administered with drugs that have an effect on CYP2D6, 1A2, or 2C19 metabolic pathways. Co-administration of such drugs with propranolol may lead to clinically relevant drug interactions and changes on its efficacy and/or toxicity (see in ).

Rare cases of rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with pravastatin and other drugs in this class.

Uncomplicated myalgia has also been reported in pravastatin-treated patients [see ]. Myopathy, defined as muscle aching or muscle weakness in conjunction with increases in creatine phosphokinase (CPK) values to greater than 10 times the ULN, was rare (<0.1%) in pravastatin clinical trials. Myopathy should be considered in any patient with diffuse myalgias, muscle tenderness or weakness, and/or marked elevation of CPK. Predisposing factors include advanced age (≥65), uncontrolled hypothyroidism, and renal impairment.

There have been rare reports of immune-mediated necrotizing myopathy (IMNM), an autoimmune myopathy, associated with statin use. IMNM is characterized by: proximal muscle weakness and elevated serum CPK, which persist despite discontinuation of statin treatment; muscle biopsy showing necrotizing myopathy without significant inflammation and improvement with immunosuppressive agents.

All patients should be advised to promptly report to their physician unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever or if muscle signs and symptoms persist after discontinuing PRAVACHOL.

Pravastatin therapy should be discontinued if markedly elevated CPK levels occur or myopathy is diagnosed or suspected. Pravastatin therapy should also be temporarily withheld in any patient experiencing an acute or serious condition predisposing to the development of renal failure secondary to rhabdomyolysis, e.g., sepsis; hypotension; major surgery; trauma; severe metabolic, endocrine, or electrolyte disorders; or uncontrolled epilepsy.

The risk of myopathy during treatment with statins is increased with concurrent therapy with either erythromycin, cyclosporine, niacin, or fibrates. However, neither myopathy nor significant increases in CPK levels have been observed in 3 reports involving a total of 100 post-transplant patients (24 renal and 76 cardiac) treated for up to 2 years concurrently with pravastatin 10 to 40 mg and cyclosporine. Some of these patients also received other concomitant immunosuppressive therapies. Further, in clinical trials involving small numbers of patients who were treated concurrently with pravastatin and niacin, there were no reports of myopathy. Also, myopathy was not reported in a trial of combination pravastatin (40 mg/day) and gemfibrozil (1200 mg/day), although 4 of 75 patients on the combination showed marked CPK elevations versus 1 of 73 patients receiving placebo. There was a trend toward more frequent CPK elevations and patient withdrawals due to musculoskeletal symptoms in the group receiving combined treatment as compared with the groups receiving placebo, gemfibrozil, or pravastatin monotherapy.

Cases of myopathy, including rhabdomyolysis, have been reported with pravastatin coadministered with colchicine, and caution should be exercised when prescribing pravastatin with colchicine [see ].

Pravastatin is generally well tolerated; adverse reactions have usually been mild and transient. In 4-month-long placebo-controlled trials, 1.7% of pravastatin-treated patients and 1.2% of placebo-treated patients were discontinued from treatment because of adverse experiences attributed to study drug therapy; this difference was not statistically significant.

×

Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

×

Review

Rate this treatment and share your opinion


Learn about User Reviews

Helpful tips to write a good review:

  1. Only share your first hand experience as a consumer or a care giver.
  2. Describe your experience in the Comments area including the benefits, side effects and how it has worked for you. Do not provide personal information like email addresses or telephone numbers.
  3. Fill in the optional information to help other users benefit from your review.

Reason for Taking This Treatment

(required)

Click the stars to rate this treatment

Effectiveness (required)

This medication has worked for me.




Ease of Use (required)

This medication has been easy for me to use.




Satisfaction (required)

Overall, I have been satisfied with my experience.




Write a brief description of your experience with this treatment:

2000 characters remaining

Optional Information

Help others benefit from your review by filling in the information below.
I am a:
Gender:
×

Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
×

Tips

Tips

×

Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).